CCL

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001-es BibID:BIBFORM048756
Első szerző:Kolozsvári Bence Lajos (szemész)
Cím:Alterations of Tear Mediators in Patients with Keratoconus after Corneal Crosslinking Associate with Corneal Changes / Bence Lajos Kolozsvári, András Berta, Goran Petrovski, Kata Miháltz, Péter Gogolák, Éva Rajnavölgyi, Ziad Hassan, Péter Széles, Mariann Fodor
Dátum:2013
ISSN:1932-6203
Megjegyzések:Keratoconus (KC) is the most common primary corneal ectatic disease which has considerable importance in public health. Corneal collagen crosslinking (CXL) is a procedure to mitigate progression of KC and reduce demand for corneal transplantation. Although studies have proven the efficacy of CXL regarding corneal shape, none have investigated the effects of CXL on tear biomarkers which are useful tools to understand molecular mechanisms behind CXL. Our purpose was to determine the effect of CXL on tear mediators in patients with KC and analyze associations with corneal changes. Tear samples were collected pre-CXL from 26 eyes of 23 patients and during a 12-month follow-up. The mediators' concentration was measured by Cytometric Bead Array technology. Corneal topography parameters measured by Scheimpflug Camera included: Thinnest-corneal-thickness (ThCT), keratometry values (K1, K2), Radii-Minimum (Rmin), Keratoconus-Index (KI), Center-KI (CKI), Index-of-Height Asymmetry (IHA) and Index-of-Surface Variance (ISV). At baseline, KI was correlated negatively with chemokine (C-C motif) ligand 5 (CCL5) (p=0.015) and matrix metalloproteinase (MMP)-13 (p=0.007). At day 4, interleukin (IL)-6 and IL-8 increased, while IL-13, IL-17A, interferon (IFN)-?, CCL5, MMP-13, epidermal growth factor (EGF), nerve growth factor (NGF) and plasminogen activator inhibitor (PAI-1) decreased significantly compared to pre-CXL concentrations (p?0.02). At 6 months tissue plasminogen activator (t-PA) increased (p=0.02), while at 12 months Rmin increased (p?0.004), and IL-6 and CXCL8 (p=0.005 and p=0.047) as well as K1, ISV and KI decreased. After 6 months CKI and ISV showed significant associations with IL-17A; CKI with IL-13 and ThCT with IL-13 (p?0.02), while at 12 months there were reverse associations between ThCT and IL-6, IL-13, INF?, CCL5 and PAI-1 (p?0.02). Alterations of mediators in tear fluid after CXL associate with topographic changes highlight the fact that many mediators are involved in the complex mechanisms after CXL. Further studies on biomarkers to investigate the efficacy of CXL are needed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
corneal ectatic disease
Keratoconus
Corneal collagen crosslinking
Megjelenés:Plos One. - 8 : 10 (2013), p. e76333-. -
További szerzők:Berta András (1955-) (szemész, gyermekszemész) Petrovski, Goran (1975-) (orvos) Miháltz Kata Gogolák Péter (1968-) (biológus, immunológus) Rajnavölgyi Éva (1950-) (immunológus) Hassan, Ziad (1962-) (szemész) Széles Péter Fodor Mariann (1975-) (szemész)
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001-es BibID:BIBFORM063542
035-os BibID:(cikkazonosító)e0153186 (WOS)000374131200058 (Scopus)84963717840
Első szerző:Pásztor Dorottya (szemész)
Cím:Tear Mediators in Corneal Ectatic Disorders / Pásztor Dorottya, Kolozsvári Bence Lajos, Csutak Adrienne, Berta András, Hassan Ziad, Ujhelyi Bernadett, Gogolák Péter, Fodor Mariann
Dátum:2016
ISSN:1932-6203
Megjegyzések:Purpose To compare the concentrations of 11 tear mediators in order to reveal the biochemical difference between pellucid marginal degeneration (PMD) and keratoconus (KC).MethodsWe have designed a cross-sectional study in which patients with corneal ectasia based on slit-lamp biomicroscopy and Pentacam HR (keratometry values (K1, K2, Kmax), astigmatism, minimal radius of curvature (Rmin), corneal thickness (Apex and Min), indices (surfacevariation, vertical asymmetry, keratoconus, central keratoconus, height asymmetry and decentration)) were enrolled. Eyes of keratoconic patients were similar to the PMD patients in age and severity (K2, Kmax and Rmin). Non-stimulated tear samples were collected from nine eyes of seven PMD patients, 55 eyes of 55 KC patients and 24 eyes of 24 healthy controls. The mediators' (interleukin -6, -10, chemokine ligand 5, -8, -10, matrix metalloproteinase (MMP) -9, -13, tissue inhibitor of metalloproteinases (TIMP)-1, tissue plasminogen activator, plasminogen activator inhibitor, nerve growth factor) concentrations were measured using Cytometric Bead Array.ResultsMMP-9 was the only mediator which presented relevant variances between the two patient groups (p = 0.005). The ratios of MMP-9 and TIMP-1 were 2.45, 0.40 and 0.23 in PMD, KC and the controls, respectively.ConclusionAs far as we are aware, this is the first study that aims to reveal the biochemical differences between PMD and KC. Further studies of biomarkers to investigate the precise role of these mediators need to be defined, and it is important to confirm the observed changes in a larger study to gain further insights into the molecular alterations in PMD.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 11 : 4 (2016), p. 1-14. -
További szerzők:Kolozsvári Bence Lajos (1977-) (szemész) Csutak Adrienne (1971-) (szemész) Berta András (1955-) (szemész, gyermekszemész) Hassan, Ziad (1962-) (szemész) Ujhelyi Bernadett (1981-) (szemész) Gogolák Péter (1968-) (biológus, immunológus) Fodor Mariann (1975-) (szemész)
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