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001-es BibID:	BIBFORM010489
Első szerző:	Fodor Mariann (szemész)
Cím:	Long-term kinetics of cytokine responses in human tears after penetrating keratoplasty / Fodor Mariann, Gogolák Péter, Rajnavölgyi Éva, Berta András, Kardos László, Módis László, Facskó Andrea
Dátum:	2009
Megjegyzések:	This was a kinetic study of inflammatory cytokine levels in postoperative tear samples from penetrating keratoplasty (PKP) patients with or without corneal rejection. In a prospective design, nonstimulated tears were collected from the affected eyes of 12 patients at regular intervals for 12-14 months following PKP. Nine patients retained clear grafts, whereas three suffered endothelial rejection of the corneal graft within 14 months. The concentrations of the cytokines IL-1beta, IL-6, TNF-alpha, IL-8, IL-10, and IL-12p70 were measured via cytometric bead array technology. The postoperative concentrations of the cytokines in the tears varied among the patients, but exhibited similar alteration patterns in each eye tested. The concentrations of IL-6 and IL-8 were significantly higher (P = 0.009 and P = 0.01, respectively), whereas those of IL-10, TNF-alpha, and IL-12p70 were significantly lower (P = 0.008, P = 0.006, and P = 0.0009, respectively) in the tear samples from the patients with corneal rejection as compared with those with uncomplicated corneal grafts. The ratios IL-6/IL-10 and IL-8/IL-10 were significantly higher (P = 0.0231 and P = 0.015, respectively), and TNF-alpha/IL-10 was significantly lower (P = 0.045) throughout the examination period in the patients with endothelial rejection. The enhanced release of IL-6 and IL-8 into the tears of patients with corneal graft rejection concomitant with decreased concentrations of IL-10, TNF-alpha, and IL-12p70 may possibly serve as an indicator of the rejection process. However, due to the large variation in the cytokine concentrations, the observed changes in tear composition do not categorically predict the final graft outcome.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cytokine
Megjelenés:	Journal of Interferon and Cytokine Research. - 29 : 7 (2009), p. 375-380. -
További szerzők:	Gogolák Péter (1968-) (biológus, immunológus) Rajnavölgyi Éva (1950-) (immunológus) Berta András (1955-) (szemész, gyermekszemész) Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Módis László (1964-) (szemész szakorvos, kontaktológus) Facskó Andrea (1953-) (szemész)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM006757
Első szerző:	Fodor Mariann (szemész)
Cím:	Enhanced release of IL-6 and IL-8 into tears in various anterior segment eye diseases / Fodor, M., Facsko, A., Rajnavolgyi, E., Harsfalvi, J., Bessenyei, E., Kardos, L., Berta, A.
Dátum:	2006
Megjegyzések:	To determine the levels of interleukin 6 (IL-6) and interleukin 8 (IL-8/CXCL-8) in tears collected from the eyes of normal individuals and of patients with different irritative eye diseases, in order to acquire information on the immunological changes occurring during the early postoperative period following various forms of eye surgery, including penetrating keratoplasty (PKP). METHODS: IL-6 and IL-8 levels were measured with the aid of human ultrasensitive ELISA kits in the non-stimulated tears of patients in the early postoperative period following PKP or cataract operation, and of patients with acute bacterial conjunctivitis or with a corneal foreign body. The IL-6 and IL-8 concentrations, the total amounts released in a given time and the rates of their release were calculated. RESULTS: A significant increase in IL-6 release was observed in all patient groups compared with the normal controls (p < or = 0.003). The IL-8 release levels were significantly higher in the tears of all patient groups (p < or = 0.03), except for the cataract operation group, where the IL-8 release was not significantly higher (p = 0.053) than in the control samples. No significant differences in IL-6 or IL-8 release were observed when the various patient groups were compared with each other. CONCLUSION: The release of IL-6 and IL-8 into the tears is enhanced in various anterior segment eye diseases, and this may be used as an indicator of various inflammatory reactions in the early postoperative period.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Aged, 80 and over Anterior Eye Segment Biological Markers Cataract Cataract Extraction Conjunctivitis, Bacterial Corneal Diseases Enzyme-Linked Immunosorbent Assay Follow-Up Studies Humans Interleukin-6 Interleukin-8 Middle Aged Prognosis Severity of Illness Index Tears
Megjelenés:	Ophthalmic Research. - 38 : 4 (2006), p. 182-188. -
További szerzők:	Facskó Andrea (1953-) (szemész) Rajnavölgyi Éva (1950-) (immunológus) Hársfalvi Jolán (1949-) (klinikai biokémikus) Bessenyei Emilia Kardos László (1970-) (megelőző orvostan és népegészségtan szakorvos) Berta András (1955-) (szemész, gyermekszemész)
Internet cím:	elektronikus változat DOI
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