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001-es BibID:BIBFORM046041
Első szerző:Ésik Olga
Cím:Increased Metabolic Activity in the Spinal Cord of Patients with Long-Standing Lhermitte's Sign / Olga Ésik, Tibor Csere, Klára Stefanits, Szabolcs Szakáll Jr., Zsolt Lengyel, Géza Sáfrány, Katalin Vönöczky, Erzsébet Lengyel, Judit Olajos, Gábor Bajzik, Lajos Trón
Dátum:2003
ISSN:0179-7158
Megjegyzések:To investigate the pathophysiology of the radiation-induced, chronic Lhermitte's sign (LS) on the basis of long-standing case histories with partial functional recovery. PATIENTS AND METHODS: As radiotherapy in two nasopharyngeal cancer patients, a biologically effective dose (BED) of 103.8 Gy(2) (case 1) and 94.8 Gy(2) (case 2) was delivered to the cervical spinal cord. Neurologic signs relating to the irradiated spinal cord segments developed after 2 months (case 1) and 5 years (case 2), with radiation-induced damage equivalent to grade 3 (case 1) and grade 2 (case 2) toxicity (Common Toxicity Criteria, Version 2.0). The clinical status improved to grade 2 (case 1) and grade 1 (case 2). Positron emission tomography (PET) and fibroblast clonogen assay were applied 25 and 7 years postirradiation, respectively, to characterize this rare clinical picture. RESULTS: PET demonstrated increased [(18)F]fluorodeoxyglucose (FDG) accumulation and [(15)O]butanol perfusion, but negligible [(11)C]methionine uptake in the irradiated spinal cord segments in both patients. In clonogenic assays, fibroblasts from case 1 displayed much higher radiation sensitivity than in healthy controls, while in case 2 the fibroblasts sensitivity was normal. CONCLUSIONS: These data suggests a close direct relationship between regional perfusion and metabolism of the spinal cord, similarly as in the brain. The postirradiation recovery may be related to energy-demanding conduction, explaining the increased metabolism and perfusion. The increased radiosensitivity and higher spinal cord BED may have contributed to the more severe sequelae in case 1.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Strahlentherapie Und Onkologie. - 179 : 10 (2003), p. 690-693. -
További szerzők:Csere Tibor (Pécs) Stefanits Klára (Pécs) Szakáll Szabolcs (1970-) jr. Lengyel Zsolt (nukleáris medicina szakorvos) Sáfrány Géza (Pécs; Budapest) Vönöczky Katalin Lengyel Erzsébet Olajos Judit (Nyíregyháza) Bajzik Gábor (1968-) (orvos) Trón Lajos (1941-) (biofizikus)
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2.

001-es BibID:BIBFORM039761
035-os BibID:PMID:11801705
Első szerző:Szakáll Szabolcs jr.
Cím:18F-FDG PET detection of lymph node metastases in medullary thyroid carcinoma / Szabolcs Szakáll, Olga Ésik, Gábor Bajzik, Imre Repa, Gabriella Dabasi, István Sinkovics, Péter Ágoston, Lajos Trón
Dátum:2002
Megjegyzések:Postsurgically elevated or increasing serum calcitonin levels strongly suggest the presence of residual or recurrent medullary thyroid carcinoma (MTC). Several imaging modalities (sonography, MRI, CT, scintigraphy with different types of radiolabeled ligands, etc.) are routinely used in an attempt to localize tumorous tissue, but such efforts often fail. In the search for a more reliable method, 18F-FDG PET was applied to detect tumor tissue of residual or recurrent MTC. METHODS: Forty patients with a postoperatively elevated plasma calcitonin level were included. These patients underwent routine diagnostic imaging procedures (CT, MRI, and 131I-metaiodobenzylguanidine [MIBG] whole-body planar scintigraphy or SPECT) and 18F-FDG PET examinations. Two independent experts visually analyzed the images provided by each method to detect pathologic lesions. Lymph nodes of > or = 1 cm in short diameter that were detected by radiologic methods were considered to be pathologic. 18F-FDG accumulation with a sharp contour reported by both independent observers was similarly regarded as pathologic. RESULTS: PET detected 270 foci with a high tracer accumulation, whereas only 116 lesions were detected by MRI and 141 by CT. The numbers of such foci determined by PET, MRI, and CT were 98, 34, and 34, respectively, in the neck; 25, 5, and 6, respectively, in the supraclavicular regions; and 117, 35, and 39, respectively, in the mediastinum. 131I-MIBG scintigraphy findings were positive for only 3 patients. CONCLUSION: For MTC patients with a postoperatively elevated plasma tumor marker level, PET was more sensitive and superior in localizing tumorous lymph node involvement than were the other imaging modalities, especially in the cervical, supraclavicular, and mediastinal lymphatic regions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Nuclear Medicine. - 43 : 1 (2002), p. 66-71. -
További szerzők:Ésik Olga Bajzik Gábor (1968-) (orvos) Repa Imre (1950-) (radiológus) Dabasi Gabriella Sinkovics István Ágoston Péter Trón Lajos (1941-) (biofizikus)
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3.

001-es BibID:BIBFORM031572
Első szerző:Szakáll Szabolcs jr.
Cím:Recidív medullaris pajzsmirigydaganat metastasisainak FDG-PET-vizsgálata / Szakáll Szabolcs jr., Bajzik Gábor, Repa Imre, Miklovicz Tünde, Dabasi Gabriella, Sinkovics István, Ésik Olga
Dátum:2002
Megjegyzések:Searching for metastases of medullary thyroid cancer (MTC), FDG PET was applied. PET results were compared with those of conventional diagnostic imaging procedures. After primary treatment, 52 MTC patients with elevated serum tumor marker levels and/or general symptoms (diarrhoea/flush) underwent radiological (CT/MRI), 131-iodine labeled metaiodo-benzylguanidine (MIBG) whole-body scintigraphy and FDG PET investigations. At least one pathological lesion was detected in 49 patients by PET, 35 by CT, 32 by MRI and 3 by MIGB. FDG PET was far superior to the other methods in identiying metastases in the supradiaphragmatic lymphatic regions. In the follow-up of MTC patients, involvement, especially in the cervical, supraclavicular and mediastinal lymphatic regions, compared to other imaging modalities.
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Orvosi Hetilap. - 21 : 21 suppl. 3 (2002), p. 1280-1283. -
További szerzők:Bajzik Gábor (1968-) (orvos) Repa Imre (1950-) (radiológus) Dabasi Gabriella Sinkovics István Ésik Olga Miklovicz Tünde (1972-) (vegyész)
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