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001-es BibID:	BIBFORM033116
Első szerző:	Fukunaga-Kalabis, Mizuho
Cím:	Downregulation of CCN3 expression as a potential mechanism for melanoma progressionCCN3 inhibits growth and invasion of melanoma / M. Fukunaga-Kalabis, G. Martinez, S. M. Telson, Z-J. Liu, K. Balint, I. Juhász, D. E. Elder, B. Perbal, M. Herlyn
Dátum:	2008
ISSN:	0950-9232
Megjegyzések:	Coculture of human melanocytes with keratinocytes upregulates CCN3, a matricellular protein critical to maintenance of normal homeostasis of melanocytes in the skin. CCN3 affects two fundamental features of melanocyte physiology: it inhibits melanocyte proliferation and stimulates their adhesion to the basement membrane. Here we report that expression of CCN3 is downregulated in advanced melanomas. Aggressive melanoma cell lines did not respond to treatment with CCN3 inducers, such as interleukin-1beta (IL-1beta), while less aggressive melanoma cell lines responded similarly to melanocytes. Immunostaining analyses revealed that CCN3 was present in melanoma cells close to the epidermal-dermal interface, but not in melanoma cells that had invaded deep into the dermis or had metastasized to lymph nodes. Contrary to our expectations, overexpression of CCN3 in 1205Lu metastatic melanoma cells did not affect their adhesion to collagen IV. However, CCN3 decreased the transcription and activation of matrix metalloproteinases and suppressed the invasion of 1205Lu melanoma cells. These results suggest that the lack of CCN3 in advanced melanoma cells contributes to their invasive phenotype. Whereas major matricellular proteins, such as osteopontin, tenascin or secreted protein acidic and rich in cysteine (SPARC), are strongly upregulated in melanoma cells; CCN3 is the first member of this family that is downregulated.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban melanoma CCN3 matricellular protein matrix metalloproteinase külföldön készült közlemény
Megjelenés:	Oncogene. - 27 (2008), p. 2552-2560. -
További szerzők:	Martinez, G. Telson, S. M. Liu, Zhao-Jun Bálint Katalin Elder, David E. Perbal, Bernard Herlyn, Meenhard Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	bibEB00010210
035-os BibID:	PMID:8342600
Első szerző:	Juhász István (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus)
Cím:	Growth and invasion of human melanomas in human skin grafted to immunodeficient mice / Istvan Juhasz, Steven M. Albelda, David E. Elder, George F. Murphy, Koji Adachi, Dorothee Herlyn, Istvan T. Valyi-Nagy, Meenhard Herlyn
Dátum:	1993
Megjegyzések:	An orthotopic model of human melanoma was developed in which malignant cells were injected into human skin grafted to nude and SCID mice. Melanoma cells proliferated and invaded the human skin grafts with characteristic patterns. Three of six melanomas grew as multiple nodules and infiltered the grafts without major architectural changes in the dermis, whereas the others invaded the dermis along collagen fibers with prominent endothelial vessels. By contrast, melanoma cells inoculated into mouse skin grew as diffusely expanding nodules that did not invade the murine dermis. In human skin grafts, human melanoma cells were angiogenic for human blood vessels, and murine vessels were only found at the periphery of grafts. Tumor cells invaded the human vessels, and four out of seven cell lines metastasized to lungs, suggesting that this model is useful to determine in vivo the interactions between normal and malignant human cells.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	American Journal of Pathology. - 143 : 2 (1993), p. 528-537. -
További szerzők:	Albelda, Steven M. Elder, David E. Murphy, George F. Adachi, Koji Herlyn, Dorothee Vályi-Nagy István Herlyn, Meenhard
Internet cím:	elektronikus változat
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001-es BibID:	bibEBI12846
035-os BibID:	PMID:8478142
Első szerző:	Vályi-Nagy István
Cím:	Spontaneous and induced differentiation of human melanoma cells / Istvan Valyi-Nagy, Ie-Ming Shih, Tibor Gyorfi, David Greenstein, Istvan Juhasz, David E. Elder, Meenhard Herlyn
Dátum:	1993
Megjegyzések:	Malignant melanoma cells can differentiate spontaneously in vivo and in vitro into cells with a finite lifespan. Analysis of differentiating cells from primary melanomas in culture revealed a flat, fibroblast-like morphology and expression of the fibroblast-associated marker leucine aminopeptidase (LAP). Differentiation was also observed in a minor sub-population of permanent cell lines derived from metastatic lesions. An experimental model of melanoma cell differentiation was then developed, using the pyrimidine analog bromodeoxyuridine (BUdR). BUdR-treated cells had a flat morphology, were contact-inhibited, had up to 20-fold increased surface area, expressed LAP, no longer proliferated anchorage-independently in soft agar, and 3 out of 4 cell lines were non-tumorigenic in athymic nude mice. Our results show that models of differentiation of melanoma cells can be established that help to define pathways of differentiation.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	International Journal of Cancer. - 54 : 1 (1993), p. 159-165. -
További szerzők:	Shih, Ie-Ming Győrfi Tibor Greenstein, David Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus) Elder, David E. Herlyn, Meenhard
Internet cím:	elektronikus változat DOI
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