Találati lista | Tudóstér

001-es BibID:	bibEBI12846
035-os BibID:	PMID:8478142
Első szerző:	Vályi-Nagy István
Cím:	Spontaneous and induced differentiation of human melanoma cells / Istvan Valyi-Nagy, Ie-Ming Shih, Tibor Gyorfi, David Greenstein, Istvan Juhasz, David E. Elder, Meenhard Herlyn
Dátum:	1993
Megjegyzések:	Malignant melanoma cells can differentiate spontaneously in vivo and in vitro into cells with a finite lifespan. Analysis of differentiating cells from primary melanomas in culture revealed a flat, fibroblast-like morphology and expression of the fibroblast-associated marker leucine aminopeptidase (LAP). Differentiation was also observed in a minor sub-population of permanent cell lines derived from metastatic lesions. An experimental model of melanoma cell differentiation was then developed, using the pyrimidine analog bromodeoxyuridine (BUdR). BUdR-treated cells had a flat morphology, were contact-inhibited, had up to 20-fold increased surface area, expressed LAP, no longer proliferated anchorage-independently in soft agar, and 3 out of 4 cell lines were non-tumorigenic in athymic nude mice. Our results show that models of differentiation of melanoma cells can be established that help to define pathways of differentiation.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	International Journal of Cancer. - 54 : 1 (1993), p. 159-165. -
További szerzők:	Shih, Ie-Ming Győrfi Tibor Greenstein, David Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus) Elder, David E. Herlyn, Meenhard
Internet cím:	elektronikus változat DOI
Borító:
Saját polcon: