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001-es BibID:	bibEBI12876
Első szerző:	Gyulai Rolland
Cím:	Chemotaxis of freshly separated and cultured human keratinocytes / Gyulai, R., Hunyadi, J., Kenderessy Szabó, A., Kemény, L., Dobozy, A.
Dátum:	1994
Megjegyzések:	It is generally accepted that keratinocyte migration plays a critical role in the process of wound healing. A study was therefore made of the migratory response of freshly separated and cultured human keratinocytes to factors with chemotactic properties for a variety of cells. Interleukin-lalfa (IL-lalfa), interferon-alfa (IFN-alfa), interleukin-8 (IL-8), and tumour necrosis factor alfa (TNF-alfa) were tested for their chemotactic effectiveness in a modified Boydcn chamber assay. IFN-alfa, IL-lalfa and IL-8 were demonstrated to serve as chemoattractants for freshly separated keratinocytes. For cultured cells, however, only IFN-alfa was found to display chemotactic properties. The findings demonstrate that there is significant difference between the chemotactic behaviour of freshly separated and cultured cells.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Clinical and Experimental Dermatology. - 19 : 4 (1994), p. 309-311. -
További szerzők:	Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus) Kenderessy Szabó Anna Kemény Lajos Dobozy Attila
Internet cím:	DOI
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001-es BibID:	bibEB00010209
Első szerző:	Hunyadi János (bőrgyógyász, kozmetológus, allergológus)
Cím:	Expression of monocyte/macrophage markers (CD13, CD14, CD68) on human keratinocytes in healthy and diseased skin / Hunyadi, J., Simon, M. Jr., Kenderessy Szabó A., Dobozy, A.
Dátum:	1993
Megjegyzések:	The results of several investigations proved that, in special circumstances, human keratinocytes (HKs) synthesize and express cell surface moieties characteristic of effector and/or accessory cells of the immune system, such as CD16, CD36, HLA-DR, and intercellular adhesion molecule-1 (CD54), which are all detectable on the surfaces of macrophages. In the present study, skin biopsies from healthy volunteers, from positive tuberculin skin tests, and from patients with acute urticaria (AU), lichen planus (LP), psoriasis vulgaris (PV), mycosis fungoides (MF), and purpura pigmentosa chronica (PPC) were investigated by means of a multistep immunoperoxidase method to examine the reactivity of the HKs with a panel of monoclonal antibodies (MABs) characteristic of monocyte/macrophage cell lines. In biopsies obtained from positive tuberculin tests and from clinically involved skin of patients with LP, PV, MF, or PPC, a multifocal, positive peroxidase reaction was observed on the membranes of HKs of the basal and suprabasal cell layers when the MABs OKM13 (CD13), OKM14 (CD14), and Dako-Macrophage (CD68) were used. In contrast, specific staining of the HKs was not observed with the same antibodies in the biopsies of healthy volunteers or of patients with AU or in the uninvolved skin specimens obtained from the other patients. The HKs of PV, LP, MF, PPC, and AU patients and those of the healthy subjects all failed to give positive reactions when MABs against CD11b, CD15, or CD33 were used. The published data supplement the known surface characteristics of HKs, reflecting their stage of activation and differentiation.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Dermatology. - 20 : 6 (1993), p. 341-345. -
További szerzők:	Simon Miklós Jr. Kenderessy Szabó Anna Dobozy Attila
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001-es BibID:	bibEB0001020
Első szerző:	Hunyadi János (bőrgyógyász, kozmetológus, allergológus)
Cím:	Expression of adhesion molecules and monocyte markers on cultured human keratinocytes / Hunyadi, J., Simon, M. Jr., Kenderessy Szabó A., Oláh, J., Dobozy, A.
Dátum:	1993
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal of Dermatology. - 2 (1992), p. 50-55. -
További szerzők:	Simon Miklós Jr. Kenderessy Szabó Anna Oláh J. Dobozy Attila
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001-es BibID:	bibEB00010206
Első szerző:	Hunyadi János (bőrgyógyász, kozmetológus, allergológus)
Cím:	Platelet-activating factor antagonists (BN 52021 and BN 50730) inhibit tumor necrosis factor-alfa-mediated cytotoxicity on murine L929 tumor cells / János Hunyadi, Anna Szabó Kenderessy, Ernő Duda, Piere Braquet, Attila Dobozy
Dátum:	1993
Megjegyzések:	Tumor necrosis factor (TNF)-alfa has been described as a mononuclear phagocyte-produced cytotoxin that causes the necrosis and regression of some tumors. The mechanism of the cytotoxicity and the basis for the differential cytotoxic effects of TNF against cells of various origin remains unclear. It has also been reported, that murine TNF stimulates the production of platelet-activating factor (PAF) by cultured peritoneal macrophages, and that PAF enhances TNF production by alveolar macrophages. Furthermore, it is known that the synthesis and release of PAF are inhibited by plasma proteinase inhibitors. This study was devoted to investigate the effects of two specific PAF antagonists (BN 52021 and 50730), and a proteinase inhibitor (aprotinin; Gordox R) on the TNF-induced cytotoxicity in L929 murine fibroblasts. Our present findings indicate that TNF-induced cytotoxicity is inhibited in a dose-dependent manner by the PAF antagonists studied and by the kallikrein inhibitor aprotinin. These findings provide further evidence suggesting that PAF might be involved in the process of the TNF-alfa-induced cytotoxicity of L929 mouse fibroblasts.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Molecular Immunology. - 30 :6 (1993), p. 517-519. -
További szerzők:	Kenderessy Szabó Anna Duda Ernő Braquet, Pierre Dobozy Attila
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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