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001-es BibID:	bibEB00010206
Első szerző:	Hunyadi János (bőrgyógyász, kozmetológus, allergológus)
Cím:	Platelet-activating factor antagonists (BN 52021 and BN 50730) inhibit tumor necrosis factor-alfa-mediated cytotoxicity on murine L929 tumor cells / János Hunyadi, Anna Szabó Kenderessy, Ernő Duda, Piere Braquet, Attila Dobozy
Dátum:	1993
Megjegyzések:	Tumor necrosis factor (TNF)-alfa has been described as a mononuclear phagocyte-produced cytotoxin that causes the necrosis and regression of some tumors. The mechanism of the cytotoxicity and the basis for the differential cytotoxic effects of TNF against cells of various origin remains unclear. It has also been reported, that murine TNF stimulates the production of platelet-activating factor (PAF) by cultured peritoneal macrophages, and that PAF enhances TNF production by alveolar macrophages. Furthermore, it is known that the synthesis and release of PAF are inhibited by plasma proteinase inhibitors. This study was devoted to investigate the effects of two specific PAF antagonists (BN 52021 and 50730), and a proteinase inhibitor (aprotinin; Gordox R) on the TNF-induced cytotoxicity in L929 murine fibroblasts. Our present findings indicate that TNF-induced cytotoxicity is inhibited in a dose-dependent manner by the PAF antagonists studied and by the kallikrein inhibitor aprotinin. These findings provide further evidence suggesting that PAF might be involved in the process of the TNF-alfa-induced cytotoxicity of L929 mouse fibroblasts.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Molecular Immunology. - 30 :6 (1993), p. 517-519. -
További szerzők:	Kenderessy Szabó Anna Duda Ernő Braquet, Pierre Dobozy Attila
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM045969
Első szerző:	Nagy Tünde
Cím:	Tumor cells expressing membrane-bound tumor necrosis factor activate macrophages and have a compromised growth in immunosuppressed and immunodeficient mice / Tünde Nagy, Hristos Glavinas, Nóra Szincsák, János Hunyadi, Tamás Jánossy, Ernő Duda, Csaba Vizler, István Juhász
Dátum:	2003
ISSN:	0304-3835
Megjegyzések:	Tumor necrosis factor (TNF)-alpha producing tumors as vaccines were demonstrated to induce a therapeutic anti-tumor immune response, but their clinical use is limited by the toxicity of soluble TNF. We investigated the growth characteristics and immunomodulatory properties of HeLa cells producing an uncleavable transmembrane form of TNF (preTNF). The growth of the transformed tumors was compromised in both immunosuppressed and severe combined immunodeficient mice; no signs of TNF toxicity were detected. Macrophages co-cultured with the transformed cells showed increased phagocytosis and cytokine production, indicating that activated macrophages may be the mediators of the anti-tumor effect. preTNF producing tumor cells are promising safe anti-tumor vaccine candidates.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Cancer Letters. - 196 : 1 (2003), p. 49-56. -
További szerzők:	Glavinas, Hristos Szincsák Nóra Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus) Jánossy Tamás Duda Ernő Vizler Csaba Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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