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001-es BibID:BIBFORM005628
Első szerző:Édes István Ferenc (kardiológus)
Cím:Late-stage alterations in myofibrillar contractile function in a transgenic mouse model of dilated cardiomyopathy (Tgalphaq*44) / Edes, I. F., Toth, A., Csanyi, G., Lomnicka, M., Chlopicki, S., Edes, I., Papp, Z.
Dátum:2008
ISSN:1095-8584 (Electronic)
Megjegyzések:Mechanical and biochemical alterations were investigated in permeabilized cardiomyocytes along with the progression of dilated cardiomyopathy (DCM) in a transgenic mouse line overexpressing the activated Galphaq protein (Tgalphaq*44). The isometric force, its Ca(2+) sensitivity (pCa(50)) and the turnover rate of the actin-myosin cycle (k(tr)) were determined at sarcomere lengths (SLs) of 1.9 mum and 2.3 mum before (at 4 and 10 months of age) and after hemodynamic decompensation (at 14 and 18 months of age) in Tgalphaq*44 cardiomyocytes and in age-matched control cardiomyocytes. The SL-dependence of pCa(50) was not different in Tgalphaq*44 and control hearts. In contrast, a significant increase in pCa(50) was observed in the Tgalphaq*44 cardiomyocytes (DeltapCa(50): 0.10-0.15 vs. the controls) after 10 months of age that could be diminished by exposures to the catalytic subunit of protein kinase A (PKA). Accordingly, a decline in endogenous PKA activity and decreased troponin I phosphorylation were detected after 10 months in the Tgalphaq*44 hearts. Finally, the maximal Ca(2+)-activated force (F(o)) and k(tr) were lower and the passive force (F(passive)) was higher at 18 months in the Tgalphaq*44 cardiomyocytes compared to the control. These mechanical alterations were paralleled by a robust increase in beta-myosin heavy chain expression in the Tgalphaq*44 hearts. In conclusion, our data suggested that an initial decrease of PKA signaling and subsequent changes in myofilament protein expression may contribute to the development of dilated cardiomyopathy in Tgalphaq*44 hearts.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Cardiomyopathy, Dilated
Cattle
Cells, Cultured
Disease Models, Animal
Female
GTP-Binding Protein alpha Subunits
Male
Mice
Mice, Transgenic
Models, Cardiovascular
Myocardial Contraction
Myocytes, Cardiac
Myofibrils
Megjelenés:Journal of Molecular and Cellular Cardiology. - 45 : 3 (2008), p. 363-372. -
További szerzők:Tóth Attila (1971-) (biológus) Csányi Gábor Lomnicka, Magdalena Chlopicki, Stefan Édes István (1952-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász)
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2.

001-es BibID:BIBFORM002144
Első szerző:Édes István Ferenc (kardiológus)
Cím:Rate of tension redevelopment is not modulated by sarcomere length in permeabilized human, murine, and porcine cardiomyocytes / Edes I. F., Czuriga D., Csányi G., Chlopicki S., Recchia F. A., Borbély A., Galajda Z., Edes I., van der Velden J., Stienen G. J., Papp Z.
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. - 293 : 1 (2007), p. R20-R29. -
További szerzők:Czuriga Dániel (1982-) (kardiológus) Csányi Gábor Chlopicki, Stefan Recchia, Fabio A. Borbély Attila (1978-) (kardiológus) Galajda Zoltán (1962-) (szívsebész, érsebész) Édes István (1952-) (kardiológus) Velden, Jolanda, van der Stienen, Ger J. M. Papp Zoltán (1965-) (kardiológus, élettanász)
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