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001-es BibID:BIBFORM005624
Első szerző:Barta Judit (kardiológus)
Cím:Antiplatelet agents sarpogrelate and cilostazol affect experimentally-induced ventricular arrhythmias and mortality / Barta, J., Sanganalmath, S. K., Kumamoto, H., Takeda, N., Edes, I., Dhalla, N. S.
Dátum:2008
ISSN:1530-7905 (Print)
Megjegyzések:Antiplatelet agents, sarpogrelate (SAR), a 5-hydroxy tryptamine 2A receptor antagonist and cilostazol (CIL), a phosphodiesterase-III inhibitor, were observed to be beneficial in attenuating cardiac remodeling and improving cardiac function in congestive heart failure due to myocardial infarction in rats; however, CIL increased ventricular tachycardia and mortality. In order to study the effects of these antiplatelet agents on arrhythmias, Sprague-Dawley rats were pretreated with either SAR or CIL (5 mg/kg/day) for 2 weeks and were then either injected cumulative doses of epinephrine (Epi) or subjected to coronary occlusion. Saline-treated animals served as controls. Electrocardiographic analysis revealed that SAR pretreatment decreased the incidence and severity of ventricular arrhythmias (time of onset of arrhythmias as well as the occurrence of premature ventricular contractions, salvos, tachycardia, and fibrillations), whereas CIL treatment augmented the incidence of cardiac arrhythmias due to both Epi and coronary occlusion. None of the drugs affected the corrected QT interval significantly. Furthermore, the levels of cyclic adenosine monophosphate (cAMP) in left ventricle were markedly higher in CIL-pretreated rats when compared to SAR-pretreated or control rats. It is suggested that an excessive level of cAMP may contribute to increase incidence of ventricular arrhythmias and mortality in animals pretreated with CIL, unlike the SAR-pretreated rats.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Anti-Arrhythmia Agents/*pharmacology
Arrhythmias, Cardiac/*chemically induced/metabolism/*prevention & control
Coronary Occlusion/complications/*drug therapy/metabolism
Cyclic AMP/metabolism
Disease Models, Animal
Electrocardiography
Epinephrine
Heart Ventricles/drug effects/metabolism
Male
Platelet Aggregation Inhibitors/adverse effects/*pharmacology
Rats
Rats, Sprague-Dawley
Succinates/*pharmacology
Tetrazoles/*adverse effects
Time Factors
Up-Regulation
Megjelenés:Cardiovasc Toxicology. - 8 : 3 (2008), p. 127-135. -
További szerzők:Sanganalmath, Santosh K. Kumamoto, Hideo Takeda, Nobuakira Édes István (1952-) (kardiológus) Dhalla, Naranjan S.
Internet cím:elektronikus változat
elektronikus változat
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