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001-es BibID:	BIBFORM005634
Első szerző:	Jebelovszki Éva
Cím:	High-fat diet-induced obesity leads to increased NO sensitivity of rat coronary arterioles : role of soluble guanylate cyclase activation / Jebelovszki, E., Kiraly, C., Erdei, N., Feher, A., Pasztor, T. E., Rutkai, I., Forster, T., Edes, I., Koller, A., Bagi, Z.
Dátum:	2008
ISSN:	0363-6135 (Print)
Megjegyzések:	The impact of obesity on nitric oxide (NO)-mediated coronary microvascular responses is poorly understood. Thus NO-mediated vasomotor responses were investigated in pressurized coronary arterioles ( approximately 100 microm) isolated from lean (on normal diet) and obese (fed with 60% of saturated fat) rats. We found that dilations to acetylcholine (ACh) were not significantly different in obese and lean rats (lean, 83 +/- 4%; and obese, 85 +/- 3% at 1 microM), yet the inhibition of NO synthesis with N(omega)-nitro-l-arginine methyl ester reduced ACh-induced dilations only in vessels of lean controls. The presence of the soluble guanylate cyclase (sGC) inhibitor oxadiazolo-quinoxaline (ODQ) elicited a similar reduction in ACh-induced dilations in the two groups of vessels (lean, 60 +/- 11%; and obese, 57 +/- 3%). Dilations to NO donors, sodium nitroprusside (SNP), and diethylenetriamine (DETA)-NONOate were enhanced in coronary arterioles of obese compared with lean control rats (lean, 63 +/- 6% and 51 +/- 5%; and obese, 78 +/- 5% and 70 +/- 5%, respectively, at 1 microM), whereas dilations to 8-bromo-cGMP were not different in the two groups. In the presence of ODQ, both SNP and DETA-NONOate-induced dilations were reduced to a similar level in lean and obese rats. Moreover, SNP-stimulated cGMP immunoreactivity in coronary arterioles and also cGMP levels in carotid arteries were enhanced in obese rats, whereas the protein expression of endothelial NOS and the sGC beta1-subunit were not different in the two groups. Collectively, these findings suggest that in coronary arterioles of obese rats, the increased activity of sGC leads to an enhanced sensitivity to NO, which may contribute to the maintenance of NO-mediated dilations and coronary perfusion in obesity.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Acetylcholine Adaptation, Physiological Animals Arterioles Blotting, Western Coronary Vessels Cyclic GMP Dietary Fats Disease Models, Animal Dose-Response Relationship, Drug Enzyme Activation Enzyme Inhibitors Enzyme-Linked Immunosorbent Assay Guanylate Cyclase Immunohistochemistry Male NG-Nitroarginine Methyl Ester Nitric Oxide Nitric Oxide Donors Nitric Oxide Synthase Type II Nitroprusside Nitroso Compounds Obesity Rats Rats, Wistar Receptors, Cytoplasmic and Nuclear Vasodilation Vasodilator Agents
Megjelenés:	American Journal of Physiology. Heart and Circulatory Physiology. - 294 : 6 (2008), p. H2558-H2564. -
További szerzők:	Király Csaba Erdei Nóra (1979-) (orvos) Fehér Attila (1982-) (orvos) Pásztorné Tóth Enikő (1966-) (laboratóriumi analitikus) Rutkai Ibolya (1985-) (molekuláris biológus) Forster Tamás Édes István (1952-) (kardiológus) Koller Ákos Bagi Zsolt (1974-) (orvos)
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001-es BibID:	BIBFORM003766
Első szerző:	Szűk Tibor (kardiológus)
Cím:	Effect of timing of clopidogrel administration on 30-day clinical outcomes : 300-mg loading dose immediately after coronary stenting versus pretreatment 6 to 24 hours before stenting in a large unselected patient cohort / Szuk, T., Gyongyosi, M., Homorodi, N., Kristof, E., Kiraly, C., Edes, I. F., Facsko, A., Pavo, N., Sodeck, G., Strehblow, C., Farhan, S., Maurer, G., Glogar, D., Domanovits, H., Huber, K., Edes, I.
Dátum:	2007
Megjegyzések:	The aim of our prospective multicenter Clopidogrel Registry was to evaluate the efficacy and safety of a 300-mg loading dose of clopidogrel at the time of ad hoc stenting in patients with suspected coronary artery disease who were not pretreated with clopidogrel for any reason, and to compare the 30-day clinical event rates with the outcome of patients pretreated with a loading dose of clopidogrel 6 to 24 hours before stenting. METHODS: Between March 2002 and February 2004, 4160 consecutively included patients received a 300-mg loading dose of clopidogrel immediately after (group 1, n = 2679) or 6 to 24 hours before stenting (group 2, n = 1481). RESULTS: The primary end point (triple composite end point of acute myocardial infarction, all-cause death, and urgent repeat target vessel revascularization) at 30 days occurred in 4.74% versus 2.77% in groups 1 and 2, respectively (P = .002). The secondary end point events, the stent thrombosis, occurred significantly more frequently in group 1, with a trend toward increase in incidence of death, target vessel revascularization, or need for glycoprotein IIb/IIIa antagonists during percutaneous coronary intervention. Pretreatment with clopidogrel was associated with more major bleeding (secondary safety end point) (0.41% vs 1.35% in groups 1 and 2, respectively; P = .001). CONCLUSIONS: The results of our multicenter prospective Clopidogrel Registry demonstrate lower efficacy of a 300-mg loading dose of clopidogrel at the time of stenting compared with pretreatment 6 to 24 hours before percutaneous coronary intervention on the 30-day composite clinical end point in the large unselected patient cohort, which suggests the benefit of clopidogrel pretreatment in all incoming patients with suspected significant coronary artery disease scheduled for coronary angiography
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban administration &amp analogs &amp Combined Modality Therapy Coronary Angiography Coronary Artery Disease derivatives dosage Drug Administration Schedule drug therapy Female Humans Male methods Middle Aged Myocardial Infarction Myocardial Revascularization Platelet Aggregation Inhibitors Preoperative Care Prospective Studies Registries Stents surgery Ticlopidine Time Factors Treatment Outcome
Megjelenés:	American Heart Journal. - 153 : 2 (2007), p. 289-295. -
További szerzők:	Gyöngyösi Mariann Homoródi Nóra (1974-) (kardiológus) Kristóf Éva (1963-) (kardiológus) Király Csaba Édes István Ferenc (1980-) (kardiológus) Facskó Andrea (1953-) (szemész) Pavo, Noemi Sodeck, Gottfried Strehblow, Christoph Farhan, Serdar Maurer, Gerald Glogar, Dietmar Domanovits, Hans Huber, Kurt Édes István (1952-) (kardiológus)
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