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001-es BibID:	BIBFORM050281
Első szerző:	Jenes Ágnes (élettanász)
Cím:	The role of the cholinergic and purinergic interaction in the contraction of the cultured human and rat urinary bladder smooth muscle cells / A. Jenes, F. Ruzsnavszky, E. A. Széll, A. Varga, G. T. Somogyi, L. Csernoch, G. P. Szigeti
Dátum:	2006
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:	Journal of Muscle Research and Cell Motility. - 27 (2006), p. 498. -
További szerzők:	Ruzsnavszky Ferenc (1984-) (élettanász) Széll Enikő A. Varga A. Somogyi George T. Csernoch László (1961-) (élettanász) Szigeti Gyula (1969-) (élettanász, elektrofiziológus)
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001-es BibID:	BIBFORM009078
Első szerző:	Lai, Henry H.
Cím:	Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder / Lai, H. H., Smith, C. P., Munoz, A., Boone, T. B., Szigeti, G. P., Somogyi, G. T.
Dátum:	2008
ISSN:	1873-2747 (Electronic)
Megjegyzések:	In the present study, the plasticity of the non-adrenergic non-cholinergic (NANC) response was investigated. Isolated rat bladder strips were electrically stimulated and the evoked contractions were isometrically recorded. The NANC part of the contractions were unmasked by applying 500 nM 4-DAMP, a potent muscarinic antagonist. Treatment of the bladder strips with 10 microM carbachol (a cholinergic agonist) increased the muscle tone but did not alter the neurally evoked contractions. However, carbachol decreased: (1) the NANC response from 74.6% to 33.3% of control and (2) the purinergic contractile response to alpha,beta-methylene ATP (alpha,beta-mATP) (10 microM) from 97.0% to 43.4% (p<0.05). Treatment with the cholinesterase inhibitor eserine (10 microM) also significantly decreased the NANC response to 21.1% (p<0.0001). The purinergic receptor antagonist suramin (100 microM) did not affect the neurally evoked contractions, however; subsequent addition of 4-DAMP decreased the contractions to 31%. Activation of the smooth muscle cholinergic receptors (with carbachol or eserine) and purinergic receptors (with alpha,beta-mATP) decreased the NANC contractions and the direct contractile response to alpha,beta-mATP. When the electrically evoked contractions were facilitated by the L-type Ca2+ channel activator, Bay-K 8644 the subsequent application of 4-DAMP did not unmask inhibited NANC contractions. We conclude that activation of muscarinic receptors by cholinergic agonist, carbachol or by endogenous acetylcholine (ACh) induce a cascade of events that leads to diminished purinergic response and consequently an inhibition of the bladder NANC response.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester Adenosine Triphosphate Animals Antineoplastic Agents Atropine Calcium Channel Agonists Carbachol Cholinergic Agonists Cholinesterase Inhibitors Electric Stimulation Female Muscarinic Antagonists Muscle Contraction Muscle Relaxation Muscle, Smooth Physostigmine Piperidines Rats Rats, Sprague-Dawley Receptors, Cholinergic Suramin Urinary Bladder
Megjelenés:	Brain Research Bulletin. - 77 (2008), p. 420-426. -
További szerzők:	Smith, Christopher P. Munoz, Alvaro Boone, Timothy B. Szigeti Gyula (1969-) (élettanász, elektrofiziológus) Somogyi George T.
Internet cím:	DOI elektronikus változat
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001-es BibID:	BIBFORM040116
Első szerző:	Szigeti Gyula (élettanász, elektrofiziológus)
Cím:	Age-dependence of the spontaneous activity of the rat urinary bladder / Szigeti G. P., Somogyi G. T., Csernoch L., Széll E. A.
Dátum:	2005
ISSN:	0142-4319
Megjegyzések:	Abnormal mechanical function of the bladder is manifested in a number of ways including higher frequency of involuntary detrusor contractions associated with reduced compliance of the bladder that is responsible for an increase in intraluminal pressure during filling. There are basically two ways to approach experimentally these problems: (1) by studying the neural control of the lower urinary tract function, and (2) by measuring the properties of smooth muscle cells in the bladder wall. Studies on smooth muscle function often do not take the origin of smooth muscle cells into account i.e., whether they were harvested from normal or overactive bladders. Although, this simplistic view may be beneficial to understanding the generation of the spontaneous activity of the bladder, however, it does not sufficiently explain the cell-to-cell propagation of the spontaneous smooth muscle activity. The spontaneous activity of smooth muscle is an important factor that works against the bladder compliance in the filling phase, and may inversely affect the neurally evoked response during micturition. The intensity of spontaneous activity is the age-dependent; it is high in neonatal bladders it is small or almost non-existent in adults and reemerges in older bladders. This review focuses on these age-dependent alterations of spontaneous bladder contractions and describes the possible mechanisms which may have important role in regulating the spontaneous contractions using the rat as an animal model.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Muscle Research And Cell Motility. - 26 : 1 (2005), p. 23-29. -
További szerzők:	Somogyi George T. Csernoch László (1961-) (élettanász) Széll Enikő A.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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