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001-es BibID:BIBFORM034474
Első szerző:Kovács Tibor (élettanász)
Cím:The subcellular location of potassium flux pathways in frog skeletal muscle / Tibor Kovács, György Pfliegler, Béla Szabó
Dátum:1981
ISSN:0031-6768
Megjegyzések:The influence of ouabain and physostigmine on 42K and 86Rb uptake in isolated from sartorii with normal [Na]i(12-14 mmol.kg -1 wet weight) and low [Na]i (6 mmol.kg-1 wet weight) was compared. Both in normal sodium and in low sodium muscles application of 10-3 M physostigmine reduces potassium influx by about 70%. About one forth of potassium-uptake in normal-sodium muscles is inhibited by ouabain (10-4 M) and only a very slight fraction of potassium uptake is ouabain-sensitive in low-sodium muscle. The effects of ouabain and physostigmine on 42K influx are additive. The greater parts of the Rb-fluxes are through the ouabain-sensitive pathway. Glycerol treatment has no effect on ouabain-sensitive channels although it inhibits markedly the K-flux through the physostigmine-sensitive pathway. The results suggest that the Na-K-ATPase is located in the surface membrane while most of the physostigmine-sensitive K-exchange is within the tubules.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
K-, Rb-uptake
Ouabain
Physostigmine
Glycerol treatment
Surface membrane
Transverse tubules
Frog muscle
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pflügers Archiv. - 390 : 3 (1981), p. 250-255. -
További szerzők:Pfliegler György (1949-) (belgyógyász, hematológus, labor szakorvos) Szabó Béla (orvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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2.

001-es BibID:BIBFORM032157
035-os BibID:PMID:6314242 WOS:A1983RG12600010
Első szerző:Pfliegler György (belgyógyász, hematológus, labor szakorvos)
Cím:The influence of catecholamines on Na, K transport in slow- and fast-twitch muscles of the rat / György Pfliegler, Imre Szabó, Tibor Kovács
Dátum:1983
ISSN:0031-6768
Megjegyzések:The effects of catecholamines on active sodium and potassium transport was compared in slow- (SOL) and fast-twitch (EDL) skeletal muscles of the rat. Stimulation of active Na+-extrusion and K+-uptake induced by adrenaline (6-30 mumol . l-1) and isoprenaline (1-40 mumol . l-1) was markedly greater in slow- than in fast-twitch muscle. In sodium-preloaded muscles the maximal stimulation of 24Na-efflux induced by adrenaline was about 2-fold higher in SOL than in EDL. Isoprenaline caused a 2.4-fold increase in ouabain-sensitive 86Rb influx in SOL muscle, but failed to alter the ouabain-sensitive influx in EDL. The stimulating action of isoprenaline on 86Rb influx in EDL was due to an increase in the ouabain-insensitive fraction of Rb uptake. The effects of catecholamines of fast- and slow-twitch muscles were probably due to the accumulation of cyclic AMP, however the fact that there were no significant differences between the nucleotides levels in fast- and slow-twitch muscle suggests the participation of other mechanism as well. The results presented suggest that cyclic AMP-induced stimulation of ouabain-insensitive transport of cation in the isolated EDL muscle of the rat is similar to that of barnacle muscle.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
chatecolamine
transport
rat
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pflügers Archiv. - 398 : 3 (1983), p. 236-240. -
További szerzők:Szabó Imre (1952-) (orvos) Kovács Tibor (1929-1994) (élettanász)
Internet cím:DOI
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