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001-es BibID:	BIBFORM034474
Első szerző:	Kovács Tibor (élettanász)
Cím:	The subcellular location of potassium flux pathways in frog skeletal muscle / Tibor Kovács, György Pfliegler, Béla Szabó
Dátum:	1981
ISSN:	0031-6768
Megjegyzések:	The influence of ouabain and physostigmine on 42K and 86Rb uptake in isolated from sartorii with normal [Na]i(12-14 mmol.kg -1 wet weight) and low [Na]i (6 mmol.kg-1 wet weight) was compared. Both in normal sodium and in low sodium muscles application of 10-3 M physostigmine reduces potassium influx by about 70%. About one forth of potassium-uptake in normal-sodium muscles is inhibited by ouabain (10-4 M) and only a very slight fraction of potassium uptake is ouabain-sensitive in low-sodium muscle. The effects of ouabain and physostigmine on 42K influx are additive. The greater parts of the Rb-fluxes are through the ouabain-sensitive pathway. Glycerol treatment has no effect on ouabain-sensitive channels although it inhibits markedly the K-flux through the physostigmine-sensitive pathway. The results suggest that the Na-K-ATPase is located in the surface membrane while most of the physostigmine-sensitive K-exchange is within the tubules.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban K-, Rb-uptake Ouabain Physostigmine Glycerol treatment Surface membrane Transverse tubules Frog muscle egyetemen (Magyarországon) készült közlemény
Megjelenés:	Pflügers Archiv. - 390 : 3 (1981), p. 250-255. -
További szerzők:	Pfliegler György (1949-) (belgyógyász, hematológus, labor szakorvos) Szabó Béla (orvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM034473
Első szerző:	Paegelow, I.
Cím:	Influence of bradykinin on calcium movements in rat uterus / I. Paegelow, T. Kovács, Gy. Pfliegler
Dátum:	1980
Megjegyzések:	In rat uterus three phases of the exchange of muscle calcium were found. An influence of bradykinin on the quantities of these compartments and on the half-times could not be demonstrated. But an increase of 45Ca efflux rate coefficient could be shown during the relaxation phase following a bradykinin-induced contraction.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Acta Biologica et Medica Germanica. - 39 : 4 (1980), p. 509-512. -
További szerzők:	Kovács Tibor (1929-1994) (élettanász) Pfliegler György (1949-) (belgyógyász, hematológus, labor szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM034475
Első szerző:	Pfliegler György (belgyógyász, hematológus, labor szakorvos)
Cím:	The inhibitory actions of eserine and ouabain on the K, Rb and Cs uptake in slow and fast twitch muscles of the rat / Gy. Pfliegler, T. Kovács, B. Szabó
Dátum:	1981
Megjegyzések:	Comparative, in vitro studies were carried out on the 42K, 86Rb, and 131Cs uptake in fast twitch extensor digitorum longus (EDL), slow twitch soleus (SOL) muscles of the rat, and in fast muscle (sartorius) of the frog. The inhibitory action of ouabain (10(-4) M) and eserine (10(-3) M) on the influxes of alkali cations was investigated. The rate of potassium influx in isolated EDL muscles was higher than that of SOL, while no difference could be found in 86Rb or 131Cs influx in the two types of mammalian muscles under in vitro condition. Ouabain inhibited to about the same extent the influx of K (25%) of both types of mammalian muscles and also in fast amphibian muscle. On the other hand, the eserine sensitive component of 42K influx in fast twitch mammalian muscle (EDL) was about one-fourth of the total influx and even less in slow twitch mammalian muscle (SOL), while in frog muscle it amounted to about two-third of the total. The "residual" potassium influx, which represents the influx remaining after simultaneous treatment of the muscles with cardiac glycoside and eserine was about half of the total in EDL and SOL, but it was only a fraction of it in the frog sartorius muscle. The results may be explained on the basis of the morphological differences of the transverse tubular and sarcoplasmic reticulum systems of fast and slow mammalian muscles.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Acta Physiologica Academiae Scientiarum Hungaricae. - 57 : 4 (1981), p. 317-328. -
További szerzők:	Kovács Tibor (1929-1994) (élettanász) Szabó Béla (orvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM032157
035-os BibID:	PMID:6314242 WOS:A1983RG12600010
Első szerző:	Pfliegler György (belgyógyász, hematológus, labor szakorvos)
Cím:	The influence of catecholamines on Na, K transport in slow- and fast-twitch muscles of the rat / György Pfliegler, Imre Szabó, Tibor Kovács
Dátum:	1983
ISSN:	0031-6768
Megjegyzések:	The effects of catecholamines on active sodium and potassium transport was compared in slow- (SOL) and fast-twitch (EDL) skeletal muscles of the rat. Stimulation of active Na+-extrusion and K+-uptake induced by adrenaline (6-30 mumol . l-1) and isoprenaline (1-40 mumol . l-1) was markedly greater in slow- than in fast-twitch muscle. In sodium-preloaded muscles the maximal stimulation of 24Na-efflux induced by adrenaline was about 2-fold higher in SOL than in EDL. Isoprenaline caused a 2.4-fold increase in ouabain-sensitive 86Rb influx in SOL muscle, but failed to alter the ouabain-sensitive influx in EDL. The stimulating action of isoprenaline on 86Rb influx in EDL was due to an increase in the ouabain-insensitive fraction of Rb uptake. The effects of catecholamines of fast- and slow-twitch muscles were probably due to the accumulation of cyclic AMP, however the fact that there were no significant differences between the nucleotides levels in fast- and slow-twitch muscle suggests the participation of other mechanism as well. The results presented suggest that cyclic AMP-induced stimulation of ouabain-insensitive transport of cation in the isolated EDL muscle of the rat is similar to that of barnacle muscle.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban chatecolamine transport rat egyetemen (Magyarországon) készült közlemény
Megjelenés:	Pflügers Archiv. - 398 : 3 (1983), p. 236-240. -
További szerzők:	Szabó Imre (1952-) (orvos) Kovács Tibor (1929-1994) (élettanász)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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