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1.

001-es BibID:BIBFORM034474
Első szerző:Kovács Tibor (élettanász)
Cím:The subcellular location of potassium flux pathways in frog skeletal muscle / Tibor Kovács, György Pfliegler, Béla Szabó
Dátum:1981
ISSN:0031-6768
Megjegyzések:The influence of ouabain and physostigmine on 42K and 86Rb uptake in isolated from sartorii with normal [Na]i(12-14 mmol.kg -1 wet weight) and low [Na]i (6 mmol.kg-1 wet weight) was compared. Both in normal sodium and in low sodium muscles application of 10-3 M physostigmine reduces potassium influx by about 70%. About one forth of potassium-uptake in normal-sodium muscles is inhibited by ouabain (10-4 M) and only a very slight fraction of potassium uptake is ouabain-sensitive in low-sodium muscle. The effects of ouabain and physostigmine on 42K influx are additive. The greater parts of the Rb-fluxes are through the ouabain-sensitive pathway. Glycerol treatment has no effect on ouabain-sensitive channels although it inhibits markedly the K-flux through the physostigmine-sensitive pathway. The results suggest that the Na-K-ATPase is located in the surface membrane while most of the physostigmine-sensitive K-exchange is within the tubules.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
K-, Rb-uptake
Ouabain
Physostigmine
Glycerol treatment
Surface membrane
Transverse tubules
Frog muscle
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pflügers Archiv. - 390 : 3 (1981), p. 250-255. -
További szerzők:Pfliegler György (1949-) (belgyógyász, hematológus, labor szakorvos) Szabó Béla (orvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM034490
Első szerző:Pfliegler György (belgyógyász, hematológus, labor szakorvos)
Cím:The effect of external sodium on ouabain-insensitive K influx in fresh human red blood cells / G. Pfliegler, Éva Kelemen, B. Szabó
Dátum:1984
Megjegyzések:The rate of 42K influx was investigated at various external sodium and ouabain concentrations in human red blood cells. In agreement with earlier reports, in red blood cells not treated with ouabain, Na did not affect K influx when [K]0 was 5.0 mM while it reduced the influx at [K]0 = 0.15 mM. However, Na stimulated 42K influx at both 5.0 mM and 0.15 mM in cells treated with ouabain (1 X 10(-5) M). When external Na concentration was raised from 0 to 72 mM the rate of 42K influx increased at [K]0 = 0.15 mM and at ouabain = 1 X 10(-5) M. The effect of external Na at different ouabain concentrations showed that K influx was inhibited by Na without or with ouabain in less than 5 X 10(-6) M while an increased K influx could be observed with higher ouabain concentrations in the incubation media. The results suggest that in the case of the complete inhibition of ouabain-sensitive K influx the electrochemical gradient of the Na ions may serve as a driving force for the inward movement of potassium.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Biochimica et Biophysica. Academiae Scientiarum Hungaricae. - 19 : 3-4 (1984), p. 281-288. -
További szerzők:Kelemen Éva Szabó Béla (orvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM034475
Első szerző:Pfliegler György (belgyógyász, hematológus, labor szakorvos)
Cím:The inhibitory actions of eserine and ouabain on the K, Rb and Cs uptake in slow and fast twitch muscles of the rat / Gy. Pfliegler, T. Kovács, B. Szabó
Dátum:1981
Megjegyzések:Comparative, in vitro studies were carried out on the 42K, 86Rb, and 131Cs uptake in fast twitch extensor digitorum longus (EDL), slow twitch soleus (SOL) muscles of the rat, and in fast muscle (sartorius) of the frog. The inhibitory action of ouabain (10(-4) M) and eserine (10(-3) M) on the influxes of alkali cations was investigated. The rate of potassium influx in isolated EDL muscles was higher than that of SOL, while no difference could be found in 86Rb or 131Cs influx in the two types of mammalian muscles under in vitro condition. Ouabain inhibited to about the same extent the influx of K (25%) of both types of mammalian muscles and also in fast amphibian muscle. On the other hand, the eserine sensitive component of 42K influx in fast twitch mammalian muscle (EDL) was about one-fourth of the total influx and even less in slow twitch mammalian muscle (SOL), while in frog muscle it amounted to about two-third of the total. The "residual" potassium influx, which represents the influx remaining after simultaneous treatment of the muscles with cardiac glycoside and eserine was about half of the total in EDL and SOL, but it was only a fraction of it in the frog sartorius muscle. The results may be explained on the basis of the morphological differences of the transverse tubular and sarcoplasmic reticulum systems of fast and slow mammalian muscles.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Physiologica Academiae Scientiarum Hungaricae. - 57 : 4 (1981), p. 317-328. -
További szerzők:Kovács Tibor (1929-1994) (élettanász) Szabó Béla (orvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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