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001-es BibID:BIBFORM041660
035-os BibID:PMID:8874864
Első szerző:Bárdos Helga (megelőző orvostan és népegészségtan szakorvos)
Cím:Fibrin deposition in primary and metastatic human brain tumours / H. Bárdos, P. Molnár, Gy. Csécsei, R. Ádány
Dátum:1996
Megjegyzések:Extravascular, intratumoral fibrin deposition is frequently observed within and around neoplastic tissue and has been implicated in various aspects of tumour growth. This is the first report on the presence and distribution of fibrinogen/fibrin in primary (14 glioblastomas) and metastatic (nine samples of lung cancer origin) human brain tumours detected by immunofluorescent techniques. All tissue samples showed specific staining for fibrinogen/fibrin. In glioblastomas fibrin deposits could be detected within and around tumour foci, while in metastatic brain tumours the tumour cell nodules were surrounded by fibrin deposits localized almost exclusively in the connective tissue compartment of tumours. Double-labelling reactions for von Willebrand factor and fibrinogen/fibrin has revealed that fibrin deposition occurred throughout the tumour stroma independently of tumour vasculature. The overlapping reactions for fibrinogen/fibrin and factor XIII subunit A, as well as the urea-insolubility of the deposits indicate the crosslinked, highly stabilized nature of fibrin both within and around tumours. Staining with Ki M7 monoclonal antibody specific for phagocytosing macrophages showed these cells to be scattered in the nonnecrotic areas in glioblastomas and to be accumulated at the interface of tumorous parenchyma and connective tissue in both primary and metastatic tumours. The close association between fibrin deposition and macrophage accumulation strongly suggests the active participation of tumour associated macrophages in the formation of stabilized intratumoral fibrin network in human brain neoplasms.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
fibrin
glioblastoma
metastatic brain tumours
tumour-associated macrophages
immunohistochemistry
egyetemen (Magyarországon) készült közlemény
Megjelenés:Blood Coagulation and Fibrinolysis. - 7 : 5 (1996), p. 536-548. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Csécsei György (1948-2005) (idegsebész) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM015551
Első szerző:Kappelmayer János (laboratóriumi szakorvos)
Cím:Consecutive appearance of coagulation factor XIII subunit A in macrophages, megakaryocytes and liver cells in early human development / Kappelmayer J., Bacskó G., Birinyi L., Zákány R., Kelemen E., Ádány R.
Dátum:1995
ISSN:0006-4971
Megjegyzések:Thirty embryonic and fetal samples were investigated to study the appearance and characteristics of factor XIII subunit A (FXIIIA)-containing cells in the course of human development. Samples were either vacuum-embedded in paraffin for staining FXIIIA by a sensitive biotin-streptavidin system or snap-frozen for double-labeling studies to characterize FXIIIA-containing cells. FXIIIA appeared as early as the fifth gestational week in yolk sac samples in stellate-shaped cells. Nonparenchymal cells in liver samples showed intense labeling for FXIIIA from the sixth week of gestation. The relative amount of FXIIIA-containing cells rapidly diminished up to the 13th gestational week. When characterized, the majority of these cells proved to be KiM7-positive macrophages, while GPIb (CD42b)-labeled cells accounted for less than 10% of FXIIIA-positive cells. Liver cells did not show any staining for FXIIIA in first trimester samples. The earliest liver specimen showing FXIIIA was at the 20th week, when FXIIIA appeared in some liver cells, particularly in those surrounding the central veins. In bone marrow smears, FXIIIA-positive cells started to appear at week 10 in the clavicles and increased in number in subsequent stages of development. Intracellular FXIIIA was distributed between GPIb-, RFD7-, and KiM7-positive cells. The results indicate that, apart from liver cells, at least three different cell populations (KiM7+ RFD7+ GPIb-, KiM7- RFD7- GPIb-, and KiM7- RFD7- GPIb+) contain FXIIIA in the early phase of human development. We conclude that FXIIIA appears very early during human development and is detectable in both extra- and intraembryonic hematopoietic organs. Intracellular FXIIIA in early human development is distributed between different macrophages and megakaryocytes, and by week 20, it appears in liver cells as well.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Blood. - 86 : 6 (1995), p. 2191-2197. -
További szerzők:Bacskó György Birinyi László (1963-) (szülész-nőgyógyász) Zákány Róza (1963-) (anatómus-, kötőszövetbiológus) Kelemen Endre Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
elektronikus változat
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