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1.

001-es BibID:BIBFORM051295
Első szerző:Ecsedi Szilvia (molekuláris biológus, genetikus)
Cím:DNA methylation characteristics of primary melanomas with distinct biological behaviour / Szilvia Irina Ecsedi, Hector Hernandez-Vargas, Sheila Coelho Lima, Laura Vizkeleti, Reka Toth, Viktoria Lazar, Viktoria Koroknai, Timea Kiss, Gabriella Emri, Zdenko Herceg, Roza Adany, Margit Balazs
Dátum:2014
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
primary melanoma
tumour progression
epigenetics
DNa methylation
hypermethylation
hypomethylation
copy number alteration
array CGH
BRAF mutation
Megjelenés:Plos One. - 9 : 5 (2014), p. e96612. -
További szerzők:Hernandez-Vargas, Hector Lima, Sheila Coelho Vízkeleti Laura (1984-) (molekuláris biológus, genetikus) Tóth Réka Lázár Viktória (1981-) (molekuláris biológus) Koroknai Viktória (1986-) (molekuláris biológus) Kiss Tímea (1986-) (molekuláris biológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Herceg Zdenko Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Pályázati támogatás:K75191
OTKA
TÁMOP 4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Egészség- és Környezettudomány
TÁMOP 4.2.4.A/2-11-1-2012-0001
TÁMOP
TÁMOP-4.2.2.A-11/1/KONV-2012-0031
TÁMOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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2.

001-es BibID:BIBFORM075508
035-os BibID:(cikkazonosító)e0197874 (WOS)000446632700001 (Scopus)85054725060
Első szerző:Llanaj, Erand (táplálkozási epidemiológus)
Cím:Examining food intake and eating out of home patterns among university students / Erand Llanaj, Róza Ádány, Carl Lachat, Marijke D'Haese
Dátum:2018
ISSN:1932-6203
Megjegyzések:Eating out of home (OH) is increasingly popular in Balkan countries, among them Albania. To date there is only anecdotal evidence regarding nutritional quality of food consumed OH and the contribution to diet. This study assessed intake of foods and drinks consumed OH and at home (AH), as well as their nutritional contribution to the daily diet of university students in Tirana, Albania. Using a single day Automated Multiple Pass Method (AMPM) 24-hour dietary recall, we examined food intake among 289 students aged 18?24 years old, from three major universities in Albania. Contribution of eating OH to total energy intake per day, as well as to daily consumption of macronutrients by eating OH intensity tertiles were assessed. Foods and drinks consumed OH contributed 46.9% [95%CI:41.4?52.8] of total daily energy intake, representing, on average, 1169.1kcal [95%CI:1088.3?1249.9]. Sweets, soft drinks and meat products were more frequently consumed OH, while fruits and vegetables consumption was extremely low. The average quantity of sugars and dietary fats per day was higher AH, 76.9g [95%CI:70.3?83.5] and 173.7g [95%CI:163.2?184.2] respectively, compared to OH, 33.7g [95%CI:30.4?37.0] and 142.0g [95%CI:131.5?152.5] respectively. Dietary composition of AH intake was richer in sugars, total fats and proteins, while OH intake was richer in saturated fats. The overall diet appeared unhealthy, when nutrients were assessed as energy percentage against WHO proposed nutrient standards for sugar and saturated fats. Eating OH, even though was associated with lower fruits and vegetables intake, was not clearly associated with poor diet quality, as AH foods were also characterized by increased saturated fats and sugars intake as energy percentage. This study provides data on the first assessment of current dietary patterns of the studied population and can be used as baseline for designing and conducting future studies and interventions targeting malnutrition in all its forms.
Tárgyszavak:Orvostudományok Egészségtudományok kutatási jelentés
folyóiratcikk
Albania
Food intake
Students
Nutrients
Nutrition
Diet
Health
Megjelenés:Plos One. - 13 : 10 (2018), p. 1-14. -
További szerzők:Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Lachat, Carl D'Haese, Marijke
Pályázati támogatás:GINOP-2.3.2-15-2016-00005
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM041549
Első szerző:Rákosy Zsuzsa (sejtbiológus, molekuláris biológus, genetikus)
Cím:Integrative genomics identifies gene signature associated with melanoma ulceration / Zsuzsa Rakosy, Szilvia Ecsedi, Reka Toth, Laura Vizkeleti, Hector Herandez-Vargas, Viktoria Lazar, Gabriella Emri, Istvan Szatmari, Zdenko Herceg, Roza Adany, Margit Balazs
Dátum:2013
Megjegyzések:BACKGROUND:Despite the extensive research approaches applied to characterise malignant melanoma, no specific molecular markers are available that are clearly related to the progression of this disease. In this study, our aims were to define a gene expression signature associated with the clinical outcome of melanoma patients and to provide an integrative interpretation of the gene expression -, copy number alterations -, and promoter methylation patterns that contribute to clinically relevant molecular functional alterations.METHODS:Gene expression profiles were determined using the Affymetrix U133 Plus2.0 array. The NimbleGen Human CGH Whole-Genome Tiling array was used to define CNAs, and the Illumina GoldenGate Methylation platform was applied to characterise the methylation patterns of overlapping genes.RESULTS:WE IDENTIFIED TWO SUBCLASSES OF PRIMARY MELANOMA: one representing patients with better prognoses and the other being characteristic of patients with unfavourable outcomes. We assigned 1,080 genes as being significantly correlated with ulceration, 987 genes were downregulated and significantly enriched in the p53, Nf-kappaB, and WNT/beta-catenin pathways. Through integrated genome analysis, we defined 150 downregulated genes whose expression correlated with copy number losses in ulcerated samples. These genes were significantly enriched on chromosome 6q and 10q, which contained a total of 36 genes. Ten of these genes were downregulated and involved in cell-cell and cell-matrix adhesion or apoptosis. The expression and methylation patterns of additional genes exhibited an inverse correlation, suggesting that transcriptional silencing of these genes is driven by epigenetic events.CONCLUSION:Using an integrative genomic approach, we were able to identify functionally relevant molecular hotspots characterised by copy number losses and promoter hypermethylation in distinct molecular subtypes of melanoma that contribute to specific transcriptomic silencing and might indicate a poor clinical outcome of melanoma.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:PLoS One. - 8 : 1 (2013), p. e54958. -
További szerzők:Ecsedi Szilvia (1982-) (molekuláris biológus, genetikus) Tóth Réka Vízkeleti Laura (1984-) (molekuláris biológus, genetikus) Hernandez-Vargas, Hector Lázár Viktória (1981-) (molekuláris biológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Szatmári István (1971-) (biológus) Herceg Zdenko Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Pályázati támogatás:OTKA K75191
OTKA
TÁMOP 4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Egészség- és Környezettudomány
TÁMOP-4.2.2.A-11/1/KONV-2012-0031
TÁMOP
A legnagyobb súlyú népbetegségek genetikai meghatározottsága a magyar populációban
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM100561
035-os BibID:(cikkazonosító)e0264363 (WOS)000793394000019 (Scopus)85125477470
Első szerző:Sándor János (orvos-epidemiológus)
Cím:COVID-19 vaccination coverage in deprived populations living in segregated colonies : a nationwide cross-sectional study in Hungary / Sándor János, Vincze Ferenc, Shrikant Maya Liza, Kőrösi László, Ulicska László, Kósa Karolina, Ádány Róza
Dátum:2022
ISSN:1932-6203
Megjegyzések:The segregated colonies (SCs) in Hungary are populated mainly but not exclusively by Roma. Their health care use is restricted in many respects. It has not been studied yet, whether fair COVID-19 vaccination coverage achieved in Hungary is accompanied with fair effectiveness in SCs. Using census data, the vaccination coverage in SCs and the complementary areas (CAs) in the same settlements of the country was determined. To describe the settlement level differences, the vaccination coverage (until June 30, 2021) in SCs were compared to those in CAs by age, sex, and eligibility for exemption certificate standardized measures. Aggregating settlement level data, the level of geographic discrimination in Hungary was also determined. According to nationwide aggregates, crude vaccination coverage was significantly lower in SCs (40.05%, 95% CI 39.87%-40.23%) than in CAs (65.42%, 95% CI 65.37%-65.46%). The relative standardized vaccination coverage was 0.643 (95% CI 0.639?0.647) in SCs. A total of 437 of the 938 investigated settlements showed significant local vaccination disparities. Hungarian citizens living in SCs, mainly of Roma ethnicity, are a distinct high-risk group. Special intervention adapted to SCs is needed to mitigate inequality in vaccination coverage and further consequences of the pandemic.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 17 : 2 (2022), p. e0264363-. -
További szerzők:Vincze Ferenc (1987-) (táplákozástudományi szakember, epidemiológus) Shrikant, Maya Liza Kőrösi László Ulicska László Kósa Karolina (1962-) (népegészségügyi szakember) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:BM/6327-3/2021, FEIF/951/2021-ITM
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM086819
035-os BibID:(cikkazonosító)e0234547 (WOS)000542759600049 (Scopus)85086691856
Első szerző:Soltész Beáta
Cím:The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population / Beáta Soltész, Péter Pikó, János Sándor, Zsigmond Kósa, Róza Ádány, Szilvia Fiatal
Dátum:2020
ISSN:1932-6203
Megjegyzések:Estimating the prevalence of cardiovascular diseases (CVDs) and risk factors among the Roma population, the largest minority in Europe, and investigating the role of genetic or environmental/behavioral risk factors in CVD development are important issues in countries where they are significant minority. This study was designed to estimate the genetic susceptibility of the Hungarian Roma (HR) population to essential hypertension (EH) and compare it to that of the general (HG) population. Twenty EH associated SNPs (in AGT, FMO3, MTHFR-NPPB, NPPA, NPPA-AS1, AGTR1, ADD1, NPR3-C5orf23, NOS3, CACNB2, PLCE1, ATP2B1, GNB3, CYP1A1-ULK3, UMOD and GNAS-EDN3) were genotyped using DNA samples obtained from HR (N = 1176) and HG population (N = 1178) subjects assembled by cross-sectional studies. Allele frequencies and genetic risk scores (unweighted and weighted genetic risk scores (GRS and wGRS, respectively) were calculated for the study groups and compared to examine the joint effects of the SNPs. The susceptibility alleles were more frequent in the HG population, and both GRS and wGRS were found to be higher in the HG population than in the HR population (GRS: 18.98 ? 3.05 vs. 18.25 ? 2.97, p<0.001; wGRS: 1.4 [IQR: 0.93?1.89] vs. 1.52 [IQR: 0.99?2.00], p<0.01). Twenty-seven percent of subjects in the HR population were in the bottom fifth (GRS ? 16) of the risk allele count compared with 21% of those in the HG population. Thirteen percent of people in the HR group were in the top fifth (GRS ? 22) of the GRS compared with 21% of those in the HG population (p<0.001), i.e., the distribution of GRS was found to be left-shifted in the HR population compared to the HG population. The Roma population seems to be genetically less susceptible to EH than the general one. These results support preventive efforts to lower the risk of developing hypertension by encouraging a healthy lifestyle. Helyreigazítás: Plos One. -16 : 7 (2022). -PLoS One. -1932-6203. -1932-6203
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 15 : 6 (2020), p. 1-17. -
További szerzők:Pikó Péter (1987-) (biológus) Sándor János (1966-) (orvos-epidemiológus) Kósa Zsigmond (1953-) (orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Fiatal Szilvia (1978-) (epidemiológus, népegészségügyi szakember)
Pályázati támogatás:TÁMOP 4.2.2.A-11/1/KONV-2012-0031
TÁMOP
GINOP-2.3.2-15-2016-00005
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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