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1.

001-es BibID:BIBFORM029089
Első szerző:Ádány Róza (megelőző orvostan és népegészségtan szakorvos)
Cím:Factor XIII of blood coagulation as a nuclear crosslinking enzyme / Ádány R., Bárdos H., Antal M., Módis L., Sárváry A., Szűcs S., Balogh I.
Dátum:2001
Megjegyzések:Intracellular localization and distribution of Factor XIII subunit A (FXIIIA) was investigated in association with monocyte-macrophage differentiation in a long term culture of human monocytes by light- and electron microscopical as well as biochemical and immunobiochemical techniques. To allow the detection of FXIIIA in cells with well-preserved ultrustructure, immunosera against glutaraldehyde-derivatized recombinant FXIIIA were developed in rabbits, then characterized and used in this study. In the early phase of macrophage differentiation intranuclear accumulation of FXIIIA was detected as a transient phenomenon in cells of the 2nd day culture by optical sectioning with 0,7 microm steps in laser scanning confocal microscopy and immunoblotting technique. FXIIIA could be detected by immunoelectron microscopic postembedding staining over electrodense DNA-containing areas. Fluoresceinated monodansylcadaverine incorporation assay was used to demonstrate that FXIIIA is not only present in the nuclei, but also expresses its transglutaminase activity. Our finding of the nuclear accumulation of FXIIIA in differentiating human macrophages is also unique in that a blood clotting factor has, for the first time, been localized in nuclei and has been shown to be an intracellular crosslinking enzyme. The possible role of nuclear FXIIIA in association with cellular processes involving chromatin structure remodeling, such as cell death, cell differentiation or cellular proliferation requires further in-depth investigation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Thrombosis and Haemostasis. - 85 : 5 (2001), p. 845-851. -
További szerzők:Bárdos Helga (1969-) (megelőző orvostan és népegészségtan szakorvos) Antal Miklós (1951-) (orvos, anatómus) Módis László (1939-) (anatómus, kötőszövetbiológus) Sárváry Attila (1971-) (népegészségtan szakorvos) Szűcs Sándor (1958-) (biokémikus, vegyész) Balogh Imre
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2.

001-es BibID:BIBFORM028958
Első szerző:Ádány Róza (megelőző orvostan és népegészségtan szakorvos)
Cím:Fibrinolysis resistant fibrin deposits in lymph nodes with Hodgkin's disease / Adány R., Szegedi A., Ablin R. J., Muszbek L.
Dátum:1988
ISSN:0340-6245
Megjegyzések:Extravasal fibrin deposition is frequently observed within and around tumorous tissues and has been implicated in various aspects of tumor growth. However, no adequate information has been available on the mechanism how intratumoral interstitial fibrin deposits escape a prompt elimination by the fibrinolytic system. In this study we provide immunomorphological evidence showing that fibrin deposits in lymph nodes with Hodgkin's disease are stabilized and made resistant to fibrinolysis by factor XIII (FXIII) of blood coagulation. By double immunofluorescent labelling systems fibrin deposits were simultaneously stained for alpha 2-antiplasmin (alpha 2-AP), the main physiological inhibitor of fibrinolysis and in a number of nodular areas they were also labelled for plasmin(ogen). The detection of alpha 2-antiplasmin-plasmin complex-neoantigen (alpha 2-AP-P-Neo) revealed that alpha 2-AP reacted with plasmin, i.e., alpha 2-AP covalently linked to fibrin indeed inhibited intratumoral fibrinolysis. In addition to fibrin deposits FXIII was also found in cellular elements characterized earlier as tumor associated macrophages. These cells were attached to fibrin strands suggesting that they are involved in the intratumoral fibrin formation and might be a source of fibrin stabilizing factor in the tumor stroma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Thrombosis and Haemostasis. - 60 : 2 (1988), p. 293-297. -
További szerzők:Szegedi Andrea (1964-) (bőrgyógyász) Ablin, R. J. Muszbek László (1942-) (haematológus, kutató orvos)
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3.

001-es BibID:BIBFORM028818
Első szerző:Ádány Róza (megelőző orvostan és népegészségtan szakorvos)
Cím:Three different cell types can synthesize factor XIII subunit A in the human liver / Ádány R., Antal M.
Dátum:1996
ISSN:0340-6245
Megjegyzések:The origin of human Factor XIII subunit A (FXIII A) has been a subject of intense speculation and investigation during the last decade. The major question under dispute is whether hepatocytes can produce this clotting factor. Experimental evidence obtained by FXIII A phenotype analysis in bone marrow transplant patients clearly identified hemopoietic cells (monocytes/macrophages and/or megakaryocytes/ platelets) as a source of FXIII A, and also showed that additional extra-hemopoietic site(s) of synthesis also exist. The liver has been suggested as a possible extra-hemopoietic source of plasma FXIII A, but the cells responsible for synthesizing FXIII A were not identified yet. Our present study was designed to determine the cellular distribution of both FXIII A and its encoding mRNA in human liver samples by using light- and electron-microscopic immuno-morphological and in situ hybridization techniques. In paraformaldehyde/glutaraldehyde (PA/GA) fixed, araldite-embedded semithin sections that were immunostained by an ABC/DAB based postembedding immunocytochemical method, FXIII A could be detected in Kupffer cells, connective tissue histiocytes and hepatocytes. Immunoreactive hepatocytes were observed almost exclusively around the venae centrales. By using postembedding immunogold labeling, FXIII A could be electron-microscopically visualized in these hepatocytes in the immediate vicinity of the lamellae of the endoplasmic reticulum. By in situ hybridization using a mixture of five 32-40mer biotinylated oligonucleotides (ONs) to mRNA regions encoded by exons VI, XI and XV and a labeling system containing streptavidin conjugated with alkaline phosphatase/BCIP/NBT, the message for FXIII A could be detected in the same cell types. These results show that in human liver three different types of cells can synthesize FXIII A, but the extent of their contribution to the plasma FXIII A level will require further studies.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Thrombosis And Haemostasis. - 76 : (1996), p. 74-79. -
További szerzők:Antal Miklós (1951-) (orvos, anatómus)
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4.

001-es BibID:BIBFORM023617
Első szerző:Ádány Róza (megelőző orvostan és népegészségtan szakorvos)
Cím:Factors of the extrinsic pathway of blood coagulation in tumour associated macrophages / Adány R., Kappelmayer J., Berényi E., Szegedi A., Fábián E., Muszbek L.
Dátum:1989
Megjegyzések:Despite the growing evidence implicating intratumoural fibrin formation in the progression of malignant tumours, the origin of coagulation factors that participate in extravascular clotting has not been elucidated. Using immunohistochemical methods we attempted to detect and localize clotting factors of extrinsic pathway in different human malignant tumours. Coagulation factors II, V, VII and X (FII, FV, FVII and FX) were detected in a huge number of cells showing spindle-shaped or stellate morphology. By double immunohistochemical labellings it was demonstrated that cells containing these clotting factors express monocyte/macrophage differentiation marker antigens recognized by Leu M3, Ki M7 and DAKO-macrophage monoclonal antibodies, i.e. they represent monocyte-derived, phagocytic tumour associated macrophages (TAMs). These findings suggest that TAMs can be viewed as clot cells, which in addition to the initiation of extravascular clotting by expressing procoagulant activity can also provide all the components necessary for the extrinsic thrombin formation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Macrophages
Intratumoural fibrin formation
Clotting factors
Megjelenés:Thrombosis and Haemostasis. - 62 : 3 (1989), p. 850-855. -
További szerzők:Kappelmayer János (1960-) (laboratóriumi szakorvos) Berényi Ernő Szegedi Andrea (1964-) (bőrgyógyász) Fábián Erzsébet Muszbek László (1942-) (haematológus, kutató orvos)
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5.

001-es BibID:BIBFORM055465
Első szerző:Bárdos Helga (megelőző orvostan és népegészségtan szakorvos)
Cím:Fibrin deposits in primary and metastatic brain tumors / H. Bárdos, P. Molnár, Gy. Csécsei, R. Ádány
Dátum:1995
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Thrombosis and Haemostasis. - 73 : 6 (1995), p. 1280. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Csécsei György (1948-2005) (idegsebész) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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6.

001-es BibID:BIBFORM041661
035-os BibID:PMID:9843169
Első szerző:Bárdos Helga (megelőző orvostan és népegészségtan szakorvos)
Cím:Fibrin deposition in squamous cell carcinomas of the larynx and hypopharynx / Helga Bárdos, Attila Juhász, Gábor Répássy, Róza Ádány
Dátum:1998
Megjegyzések:Extravascular fibrin deposition is frequently observed within and around neoplastic tissue and has been implicated in various aspects of tumor growth. The distribution of fibrin deposits was investigated in squamous cell carcinomas representing different stages of tumor progression of the larynx (n = 25) and hypopharynx (n = 9) by immunofluorescent techniques. Double and treble labelings were used to detect fibrinogen and fibrin in combination with marker antigens for tumor cells (cytokeratin), endothelial cells (von Willebrand factor), macrophages (recognized by KiM7), as well as factor XIII subunit A (FXIIIA) and tenascin (an embryonic extracellular matrix protein newly expressed during tumorigenesis). All tissue samples showed specific staining for fibrinogen/fibrin. Fibrin deposition was localized almost exclusively in the connective tissue compartment of tumors with characteristic accumulation at the interface of connective tissue and the tumorous parenchyma. In certain tumor samples showing highly invasive characteristics, fibrin deposits were observed in close association with tumor blood vessels in the tumor cell nodules. The overlapping reactions with polyclonal antibody to fibrinogen/fibrin and monoclonal antibody to fibrin indicate the activation of the coagulation cascade resulting in in situ thrombin activation and fibrin formation. Fibrin was crosslinked and stabilized by FXIIIA as revealed by urea insolubility test. Accumulation of phagocytozing macrophages detected by Ki M7 monoclonal antibody could be seen in areas of fibrin deposition. The blood coagulation factor XIIIA was detected in and around the cells labeled with Ki M7 antibody. Tenascin and fibrin deposits were found in the same localization in the tumor stroma and in association with tumor blood vessels within the tumor cell nodules. Neither fibrin nor tenascin were detected in the histologically normal tissue adjacent to tumors. The close association between fibrin deposits and macrophage accumulation strongly suggests the active participation of tumor-associated macrophages in the formation of stabilized intratumoral fibrin that facilitates tumor matrix generation and tumor angiogenesis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (magyarországon) készült közlemény
Megjelenés:Thrombosis and Haemostasis. - 80 : 5 (1998), p. 767-772. -
További szerzők:Juhász Attila (fül-orr-gégész) Répássy Gábor (1947-) (fül-orr-gégész) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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7.

001-es BibID:BIBFORM034288
Első szerző:Damjanovich László (általános sebész)
Cím:Factors involved in the plasminogen activation system in human breast tumours / Damjanovich L., Turzó Cs., Ádány R.
Dátum:1994
ISSN:0340-6245
Megjegyzések:The plasminogen activation system is a delicately balanced assembly of enzymes which seems to have primary influence on tumour progression. The conversion of plasminogen into serine protease plasmin with fibrinolytic activity depends on the actual balance between plasminogen activators (urokinase type; u-PA and tissue type; t-PA) and their inhibitors (type 1 and 2 plasminogen activator inhibitors; PAI-1 and PAI-2). The purpose of this study was to determine the exact histological localization of all the major factors involved in plasminogen activation, and activation inhibition (plasmin system) in benign and malignant breast tumour samples. Our results show that factors of the plasmin system are present both in benign and malignant tumours. Cancer cells strongly labelled for both u-PA and t-PA, but epithelial cells of fibroadenoma samples were also stained for plasminogen activators at least as intensively as tumour cells in cancerous tissues. In fibroadenomas, all the epithelial cells were labelled for PAI-1. Staining became sporadic in malignant tumours, cells located at the periphery of tumour cell clusters regularly did not show reaction for PAI-1. In the benign tumour samples the perialveolar connective tissue stroma contained a lot of PAI-1 positive cells, showing characteristics of fibroblasts; but their number was strongly decreased in the stroma of malignant tumours. These findings indicate that the higher level of u-PA antigen, detected in malignant breast tumour samples by biochemical techniques, does not necessarily indicate increased u-PA production by tumour cells but it might be owing to the increased number of cells producing u-PA as well
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Thrombosis And Haemostasis. - 71 : 6 (1994), p. 684-691. -
További szerzők:Turzó Csaba (1962-) (igazságügyi orvosszakértő) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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8.

001-es BibID:BIBFORM036483
Első szerző:Muszbek László (haematológus, kutató orvos)
Cím:Monocytes of patients congenitally deficient in plasma factor XIII lack factor XIII subunit A antigen and transglutaminase activity / Muszbek L., Adány R., Kávai M., Boda Z., Lopaciuk S.
Dátum:1988
ISSN:0340-6245
Megjegyzések:Monocytes isolated from patients with severe deficiency in plasma Factor XIII of blood coagulation (FXIII) were tested for FXIII antigen and transglutaminase activity. By immunoperoxidase method the patients' monocytes, in contrast to normal controls, showed no reaction with a monospecific antibody against FXIII subunit a. This result was confirmed by immunoblotting technique, as well. In addition, tissue macrophages tested in one of the patients were also exempt of FXIII subunit a antigen. The transglutaminase activity in FXIII deficient monocytes was below the limit of the detection of the dansylcadaverine incorporation assay. The results suggest that FXIII subunit a of monocytes/macrophages and its plasma and platelet counterparts are closely related or identical proteins and demonstrate that the transglutaminase activity in monocytes is of FXIII origin and tissue transglutaminase is present, if at all, only in insignificant amount.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
factor XIII
monocytes
transglutaminase
Megjelenés:Thrombosis And Haemostasis. - 59 : 2 (1988), p. 231-235. -
További szerzők:Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Kávai Mária (1930-) (vegyész) Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus) Lopaciuk, Stanislaw
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9.

001-es BibID:BIBFORM015633
Első szerző:Töröcsik Dániel (bőrgyógyász)
Cím:Factor XIII-A is involved in the regulation of gene expression in alternatively activated human macrophages / Töröcsik, D., Szeles, L., Paragh, G., Rakosy, Z., Bardos, H., Nagy, L., Balazs, M., Inbal, A., Ádány, R.
Dátum:2010
ISSN:0340-6245
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Thrombosis and Haemostasis. - 104 : 4 (2010), p. 709-717. -
További szerzők:Széles Lajos (1971-) (molekuláris biológus) Paragh György Jr. (1978-) (bőrgyógyász) Rákosy Zsuzsa (1978-) (sejtbiológus, molekuláris biológus, genetikus) Bárdos Helga (1969-) (megelőző orvostan és népegészségtan szakorvos) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Inbal, Aida Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:Szerző által megadott URL
DOI
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10.

001-es BibID:BIBFORM001467
Első szerző:Vokó Zoltán (epidemiológus)
Cím:Factor XIII Val34Leu variant protects against coronary artery disease : a meta-analysis / Vokó Z., Bereczky Z., Katona É., Ádány R., Muszbek L.
Dátum:2007
Megjegyzések:aSeveral studies suggested that Val34Leu variant of factor XIII (FXIII) might have a protective effect against coronary artery disease (CAD), but studies not supporting these findings have also been published. The authors performed a meta-analysis of 16 studies on 5,346 cases and 7,053 controls that investigated the association between Val34Leu polymorphism and CAD defined as history of myocardial infarction or significant stenosis on a coronary artery assessed by coronary angiography. Because of the heterogeneity of the study-specific results, the pooled effect estimates were calculated by a random-effects empirical Bayes model. The combined odds ratios for CAD were 0.82 (95% confidence interval [95% CI] 0.73, 0.94) for the heterozygotes of the FXIIIVal34Leu variant, 0.89 (95% CI 0.69, 1.13) for the homozygotes, and 0.81 (95% CI 0.70, 0.92) for the heterozygotes and homozygotes combined. The results were essentially the same when only myocardial infarction was considered as outcome. The beneficial effect of the polymorphism might be smaller than the effect estimates obtained in this meta-analysis, because the analysis raised the possibility of publication bias. Data published in the literature suggest that gene-gene and gene-environmental interactions might significantly influence the protective effect of FXIII-A Val34Leu polymorphism.
Tárgyszavak:Orvostudományok Egészségtudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
coronary disease
factor XIII
polymorphism
meta-analysis
Megjelenés:Thrombosis and Haemostasis. - 97 : 3 (2007), p. 458-463. -
További szerzők:Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Katona Éva (1961-) (klinikai biokémikus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Muszbek László (1942-) (haematológus, kutató orvos)
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