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001-es BibID:	BIBFORM027661
Első szerző:	Ádám Balázs (megelőző orvostan és népegészségtan szakorvos)
Cím:	Contact stimulation of fibroblasts for tenascin production by melanoma cells / Ádám Balázs, Balázs Margit, Tóth László, Pásti Gabriella, Ádány Róza
Dátum:	2006
ISSN:	0960-8931
Megjegyzések:	Tenascin, an extracellular matrix glycoprotein, is widely expressed in the stroma of almost all types of solid tumours including malignant melanomas. On the basis of its antiadhesive character, it has been supposed that tenascin accumulation facilitates tumour cell invasion and consequent metastasis formation. We aimed to investigate the mechanism by which melanoma cells can modulate the production of tenascin by host stromal cells. The expression of tenascin in cocultures of fibroblasts and five melanoma cell lines, as well as in fibroblast monocultures treated with melanoma conditioned media, was analysed by immunofluorescent staining and image analysis. Tenascin production could not be observed in control fibroblasts or in melanoma cell monocultures. Faint labelling for tenascin could be detected in fibroblast monocultures treated with melanoma cell conditioned media while a very intense staining for tenascin could be seen in melanoma cell-fibroblast cocultures. The tenascin staining in the cocultures was associated with the fibroblasts that were in close contact with melanoma cells. The level of tenascin production around the fibroblasts in different areas of the cocultures correlated well with the density of melanoma cells. Our results indicate that tenascin production of fibroblasts in the tumour stroma is directly modulated by melanoma cells mainly through cell-to-cell contact signalling.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban coculture fibroblast melanoma tenascin tumour matrix
Megjelenés:	Melanoma Research. - 16 : 5 (2006), p. 385-391. -
További szerzők:	Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Tóth László Pásti Gabriella Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM033274
035-os BibID:	WOS:000085885000009 PMID:10766423
Első szerző:	Tóth László
Cím:	Effect of tumor-conditioned medium on intercellular communication and proliferation of Balb/c 3T3 cells / László Tóth, Gabriella Pásti, Attila Sárváry, Margit Balázs, Róza Ádány
Dátum:	2000
Megjegyzések:	The possible role of tumor cell-derived factors in the regulation of gap junctional intercellular communication and proliferation of fibroblasts was studied in a model system of Balb/c 3T3 cells growing in tumor conditioned medium by Lucifer Yellow CH dye-transfer and BrdU incorporation assays. Six to 24 h incubation of Balb/c 3T3 cells in a medium conditioned by WiDr adenocarcinoma cells enhanced the gap junctional communication between the cells by 25-40% as revealed by intercellular transfer of a fluorescent dye Lucifer Yellow CH. Simultaneously the cell proliferation rates were examined and found to be reduced by 23% at 24 h treatment. Since adenocarcinoma cells are known to secrete different growth factor-like polypeptides into their conditioned medium, we suppose that tumors that produce these molecules might alter their host environment through the enhancement of cell-cell communication thereby facilitating the exchange of modulatory factors.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban Tumor-conditioned medium Intercellular communication Cell proliferation Balb/c 3T3 cells WiDr cells egyetemen (Magyarországon) készült közlemény
Megjelenés:	Cancer Letters. - 151 : 1 (2000), p. 57-61. -
További szerzők:	Pásti Gabriella Sárváry Attila (1971-) (népegészségtan szakorvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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