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001-es BibID:BIBFORM039951
035-os BibID:PMID:11514955
Első szerző:Balázs Margit (sejtbiológus, molekuláris genetikus)
Cím:Chromosomal imbalances in primary and metastatic melanomas revealed by comparative genomic hybridization / Margit Balázs, Zsuzsa Ádám, Andrea Treszl, Ágnes Bégány, János Hunyadi, Róza Ádány
Dátum:2001
ISSN:0196-4763
Megjegyzések:Characteristic genetic changes underlying the metastatic progression of malignant melanoma is incompletely understood. The goal of our study was to explore specific chromosomal alterations associated with the aggressive behavior of this neoplasm. Comparative genomic hybridization was performed to screen and compare genomic imbalances present in primary and metastatic melanomas. Sixteen primary and 12 metastatic specimens were analyzed. We found that the pattern of chromosomal aberrations is similar in the two subgroups; however, alterations present only in primary and/or metastatic tumors were also discovered. The mean number of genetic changes was 6.3 (range 1-14) in primary and 7.8 (range 1-16) in metastatic lesions. Frequent losses involved 9p and 10q, whereas gains most often occurred at 1q, 6p, 7q, and 8q. Distinct, high-level amplifications were mapped to 1p12-p21 and 1p22-p31 in both tumor types. Amplification of 4q12-q13.1, 7q21.3-qter and 8q23-qter were detected only in primary tumors. The 20q13-qter amplicon was present in a metastatic tumor. The number of genetic alterations were significantly higher in primary tumors which developed metastases within one year after the surgery compared to tumors without metastasis during this time period. Fluorescence in situ hybridization with centromeric and locus-specific probes was applied to validate CGH results on a subset of tumors. Comparison of FISH and CGH data gave good correlation. The aggressive behavior of melanoma is associated with accumulation of multiple genetic alterations. Chromosome regions, which differ in the primary and metastatic lesions, may represent potential targets to identify metastases-related chromosomal alterations.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cytometry. - 46 : 4 (2001), p. 222-232. -
További szerzők:Ádám Zsuzsa Bégány Ágnes (1954-2011) (bőrgyógyász, kozmetológus, klinikai onkológus) Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus) Treszl Andrea (1974-) (molekuláris biológus) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
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001-es BibID:BIBFORM003596
Első szerző:Irinyi Beatrix (bőrgyógyász, allergológus)
Cím:Clinical and laboratory examinations in the subgroups of chronic urticaria / Irinyi B., Széles Gy., Gyimesi E., Tumpek J., Herédi E., Dimitrios G., Ádány R., Hunyadi J., Szegedi A.
Dátum:2007
Megjegyzések:The aetiology of chronic urticaria is heterogeneous. Physical urticaria (PU) is estimated at around 35 %, autoimmune urticaria (AIU) at 25 % and chronic idiopathic urticaria (CIU) at 35% of all chronic urticaria cases. Methods: Differences in clinical and laboratory parameters among AIU, PU and CIU groups were examined. AIU was diagnosed if basophil CD63 assay was positive. Demographic data, severity of symptoms, and association with allergic and autoimmune diseases were analysed by the aid of an internationally accepted questionnaire a questionnarie. Immunoassays were carried out and the effectiveness of therapy was also investigated. Results: Female dominance in the AIU group was prominent. Concerning the urticaria score, there were significant differences between the AIU and PU patients (p=0.015) and between AIU and CIU cases (p=0.013). Between the CIU and PU patients, we found an insignificant difference in the urticaria score (p=0.78). AIU was more frequently associated with autoimmune diseases in the personal (p<0.001), and with other types of urticaria in the family history (p<0.001). Also anti-thyroid antibodies were more frequently detected in the AIU group. Antihistamine therapy was less effective in the AIU group (12.8%) than in the PU (70.3%) and CIU groups (68.6 %), but there were no significant differences between the CIU and PU groups regarding the effectiveness of antihistamine therapy. Conclusion: The autoimmune subgroup represents the most severe form of chronic urticaria. On the other hand between the CIU and PU groups there were no significant differences in urticaria scores as well as in response to antihistamine therapy. Key words: antihistamine therapy, autoimmune urticaria, physical urticaria, chronic idiopathic urticaria
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
chronic urticaria
Megjelenés:International Archives of Allergy and Immunology 144 : 3 (2007), p. 217-225. -
További szerzők:Széles György (1969-) (epidemiológus) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Tumpek Judit (1944-) (orvosi laboratóriumi szakorvos) Herédi Emese (1979-) (bőrgyógyász) Dimitrios, Georgitsis Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus) Szegedi Andrea (1964-) (bőrgyógyász)
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