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001-es BibID:BIBFORM041405
035-os BibID:PMID:2737926
Első szerző:Ádány Róza (megelőző orvostan és népegészségtan szakorvos)
Cím:Immunohistochemical detection of factor XIII subunit a in histiocytes of human uterus / R. Ádány, L. Muszbek
Dátum:1989
Megjegyzések:As spontaneous abortion is a frequent finding in females with Factor XIII (FXIII) deficiency it has been presumed that this clotting factor is essential to normal pregnancy. FXIII subunit a (FXIII A) has been demonstrated in the homogenate of human uterus, but no information on its cellular distribution has been published, so far. In the present study first FXIII A was detected in paraformaldehyde-fixed, paraffin-embedded sections of human uterus by immunoperoxidase technique. Cells containing FXIII A were localized between collagen fibrils stained by Picrosirius Red F3B in the connective tissue. To characterize them the immunofluorescent detection of FXIII A was combined by the visualization of different marker antigens of monocytes and macrophages recognized by Leu-M3, RFD7, anti-HLA-DR and DAKO-anti-macrophage monoclonal antibodies on frozen sections. The coexpression of FXIII A with monocyte and macrophage differentiation marker antigens clearly proves that cells containing FXIII A in the uterus are monocyte-derived tissue macrophages. The results well agree with our previous findings demonstrating FXIII A in human monocytes and different types of macrophages. On the basis of these results, the presence of FXIII A does not seem to be a specificity of the uterus but a characteristic of monocyte/macrophage cell line including tissue macrophages, in general.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Histochemistry. - 91 : 2 (1989), p. 169-174. -
További szerzők:Muszbek László (1942-) (haematológus, kutató orvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM041655
035-os BibID:PMID:7560900
Első szerző:Hidasi Vanda
Cím:Localization of Transglutaminase in Human Lenses / Vanda Hidasi, Róza Ádány, László Muszbek
Dátum:1995
Megjegyzések:Transglutaminase activity has been detected in the lenses of laboratory animals and in human cataracts. However, its distribution in the lens tissue has not been investigated. Using a monoclonal antibody against tissue transglutaminase, we showed by Western blotting and immunoabsorption that transglutaminase of normal human lens is immunologically related to tissue transglutaminase but has a slightly higher M(r) than the latter enzyme. Using monoclonal or polyclonal antibody against tissue transglutaminase, lens transglutaminase was localized to the epithelial cell layer on the anterior lens surface and to a thin stripe between the capsule and the peripheral cortex on the posterior surface. Lens fibers were not stained with the antibodies. Factor XIII, another transglutaminase, could not be detected in the lens tissue. The localization of transglutaminase in the lens suggests that lens transglutaminase is synthesized in the epithelial cells and secreted into the virtual space between the capsule and the peripheral cortex spreading all around the lens substance.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Histochemistry & Cytochemistry. - 43 : 11 (1995), p. 1173-1177. -
További szerzők:Muszbek László (1942-) (haematológus, kutató orvos) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:F5469
OTKA
T16274
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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