Találati lista | Tudóstér

001-es BibID:	BIBFORM004830
035-os BibID:	WOS:000223675800046
Első szerző:	Bene László (biofizikus)
Cím:	Membrane topography of HLA I, HLA II, and ICAM-1 is affected by IFN-gamma in lipid rafts of uveal melanomas / László Bene, Andrea Bodnár, Sándor Damjanovich, György Vámosi, Zsolt Bacsó, János Aradi, András Berta, Judit Damjanovich
Dátum:	2004
Megjegyzések:	The lateral distribution and colocalization of HLA I, HLA-DR, and ICAM-1 proteins was studied for the first time in the plasma membrane of two human uveal melanoma cell lines, OCM-1 and OCM-3. Our fluorescence resonance energy transfer and confocal laser scanning microscopic experiments revealed that these molecules are mostly confined to the same membrane regions, where they form similar protein patterns (homo- and hetero-associates) to those found previously on other cell types of lymphoid as well as colorectal carcinoma origin. Confocal microscopic colocalization experiments with GM(1) gangliosides and the GPI-anchored CD59 molecules showed enrichment of HLA I, HLA-DR, and ICAM-1 molecules in specific membrane domains (lipid rafts) excluding the transferrin receptor. IFN-gamma remarkably increased the expression levels of these molecules and rearranged their association patterns, which can affect the adoptive immune response of effector cells
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Antigens Biophysics Carcinoma Cell Line Cells Energy Transfer Flow Cytometry Fluorescence Fluorescence Resonance Energy Transfer Histocompatibility Antigens Histocompatibility Antigens Class I Histocompatibility Antigens Class II Human Humans Hungary Intercellular Adhesion Molecule-1 Interferon Type II Melanoma Membrane Microdomains metabolism Microscopy,Confocal Proteins Research Support Uveal Neoplasms egyetemen (Magyarországon) készült közlemény
Megjelenés:	Biochemical and Biophysical Research Communications. - 322 : 2 (2004), p. 678-683. -
További szerzők:	Dóczy-Bodnár Andrea (1970-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Vámosi György (1967-) (biofizikus) Bacsó Zsolt (1963-) (biofizikus) Aradi János (1942-) (biokémikus, vegyész) Berta András (1955-) (szemész, gyermekszemész) Damjanovich Judit (1963-) (szemész)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM001204
Első szerző:	Bene László (biofizikus)
Cím:	Colorectal carcinoma rearranges cell surface protein topology and density in CD4+ T cells / Bene L., Kanyári Z., Bodnár A., Kappelmayer J., Waldmann T. A., Vámosi G., Damjanovich L.
Dátum:	2007
Megjegyzések:	Previously, we described conserved protein clusters includingMHCI and II glycoproteins, ICAM-1 adhesion molecules, and interleukin- 2 and -15 receptors in lipid rafts of several human cell types. Differential protein interactions can modulate function, thus influence cell fate. Therefore, we analyzed supramolecular clusters of CD4+ T cells from draining lymph nodes and peripheral blood of colorectal carcinoma patients, and compared these to healthy controls. Superclusters of MHC I and II with IL-2/15 receptors were identified by confocal microscopy on all cell types. Flow-cytometricFRETrevealed molecular associations of these proteins with each other and withICAM-1 as well. In draining lymph nodes expression levels of all these proteins were lower, and interactions, particularly between IL-2/15 receptors and MHC molecules weakened or disappeared as compared to the control. Stimuli/local conditions can rearrange cell surface protein patterns on the same cell type in the same patient, having important implications on further function and cell fate.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban CD4+ T cells colorectal carcinoma MHC I MHC II IL-2R IL-15R ICAM-1 receptor clustering FRET Flow cytometry Confocal microscopy Membrane protein association Draining lymph node
Megjelenés:	Biochemical and Biophysical Research Communications. - 361 : 1 (2007), p. 202-207. -
További szerzők:	Kanyári Zsolt (1964-) (orvos) Dóczy-Bodnár Andrea (1970-) (biofizikus) Kappelmayer János (1960-) (laboratóriumi szakorvos) Waldmann, Thomas A. Vámosi György (1967-) (biofizikus) Damjanovich László (1960-) (általános sebész)
Internet cím:	elektronikus változat DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM004716
Első szerző:	Penyige András (molekuláris genetikus)
Cím:	Depolarization of the membrane potential by beta-lactams as a signal to induce autolysis / Penyige, A., Matko, J., Deak, E., Bodnar, A., Barabas, G.
Dátum:	2002
Megjegyzések:	The effect of beta-lactam antibiotics that are known to inhibit cell wall biosynthesis and induce cell wall autolysis on the electrophysiological state of the plasma membrane in Streptomyces griseus was studied. Addition of various beta-lactam antibiotics induced a dose- and growth-stage-dependent depolarization of the membrane potential of Streptomyces griseus. The hydrolyzed biologically inactive derivative penicilloic acid had no depolarizing effect on the membrane potential. The ionophore gramicidin D, while depolarizing the membrane potential, also induced a dose-dependent increase in cell wall lysis. These observations suggest that alteration of the transmembrane potential could be an important signal in triggering cell wall autolysis of S. griseus.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Anti-Bacterial Agents Antibiotics Autolysis biosynthesis Carbocyanines Cefotaxime Coloring Agents drug effects Drug Interactions Gramicidin Hungary Ionophores Membrane Potentials metabolism Penicillin G pharmacology Research Streptomyces Streptomyces griseus Support
Megjelenés:	Biochemical and Biophysical Research Communications. - 290 : 4 (2002), p. 1169-1175. -
További szerzők:	Matkó János (1952-) (biológus) Deák Eleonóra Dóczy-Bodnár Andrea (1970-) (biofizikus) Barabás György (1933-) (sejtbiológus, molekuláris genetikus)
Internet cím:	elektronikus változat DOI
Borító:
Saját polcon: