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001-es BibID:	BIBFORM005999
Első szerző:	Surányi Péter
Cím:	B lymphocyte subsets in Hashimoto's thyroiditis / Peter Suranyi, Gyula Szegedi, Sandor Damjanovich, Ferenc Juhasz, Valeria Stenszky, Nadir R. Farid
Dátum:	1989
Megjegyzések:	Two B lymphocyte subsets are identified on the basis of possession or lack of a surface molecule, CD5. The CD5+ B lymphocytes synthesize autoantibodies and in the process rearrange proximal variables of immunoglobulin genes. We have here studied the proportion and absolute counts of CD5+ B lymphocytes in the peripheral blood of 31 patients with Hashimoto's thyroiditis and related the findings to their HLA phenotypes and clinical features. Although the percentage and absolute number of surface immunoglobulin-positive (B) lymphocytes was comparable in patients to those in twenty controls, % CD5+ was significantly higher in the patient group (38.1 +/- 11.6 [+/- S.D.] vs. 27.9 +/- 10.1, p = 0.009). The absolute CD5+ cells (microliters) were also higher in patients with Hashimoto's thyroiditis (77.90 +/- 37.50 vs. 55.1 +/- 29.8, p = 0.020). The proportion of CD5+ cells was even higher in HLA-DR3 positive patients (43.1% +/- 7.2, n = 13) compared to six DR3+ controls (26.17% +/- 9.7, p = 0.0005). The difference between DR3- patients and controls was not significant (28.6% +/- 10.5 vs. 34.4% +/- 13.0). As the CD5 molecule may be induced on activated B lymphocytes, this study suggests that Hashimoto's thyroiditis is associated with an increase of activated B lymphocytes engaged in autoantibody synthesis. This defect is particularly obvious in DR3+ patients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Antigens,CD5 Antigens,Differentiation Antigens,Differentiation,B-Lymphocyte Autoantibodies B-Lymphocytes blood classification Histocompatibility Antigens Histocompatibility Antigens Class II Human Hungary Immunoglobulins,Surface immunology Lymphocytes pathology Support,Non-U.S.Gov't Thyroiditis,Autoimmune
Megjelenés:	Immunology Letters. - 22 : 2 (1989), p. 147-150. -
További szerzők:	Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Damjanovich Sándor (1936-2017) (biofizikus) Juhász Ferenc Stenszky Valéria Farid, Nadir R.
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001-es BibID:	BIBFORM005995
Első szerző:	Surányi Péter
Cím:	Modulation of T3 antigen in systemic lupus erythematosus (SLE) / Suranyi, P., Czirják, L., Szegedi, G., Damjanovich, S.
Dátum:	1987
Megjegyzések:	One of the first steps in the T cell activation is modulation of T3-Ti complex from the cell membrane. This process was studied in patients with SLE by immunofluorescence staining and measured in a cell sorter. The modulation of T3 antigen was impaired in a number of patients. The mitogen-induced proliferation was also decreased in these cases, but decreased blast transformation occurred also with efficient modulation. Pretreatment of normal T lymphocyte with sera from patients with decreased modulation caused only moderate inhibition of T3 antigen modulation. Modulation in vitro was not influenced by steroids.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban Antibodies,Monoclonal Antigens,CD3 Antigens,Differentiation,T-Lymphocyte Binding Sites Binding Sites,Antibody Cell Membrane Cells,Cultured drug effects Flow Cytometry Human Hungary Hydrocortisone immunology In Vitro Lupus Erythematosus,Systemic Lymphocyte Transformation pharmacology T-Lymphocytes
Megjelenés:	Acta Medica Hungarica. - 44 : 4 (1987), p. 311-319. -
További szerzők:	Czirják László Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Damjanovich Sándor (1936-2017) (biofizikus)
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001-es BibID:	BIBFORM006009
Első szerző:	Szegedi Gyula (belgyógyász, immunológus)
Cím:	Antigen density on the surface of mononuclear cells in SLE / Szegedi, G., Surányi, P., Damjanovich, S.
Dátum:	1987
Megjegyzések:	Searching for the cause of the known immunological abnormalities in systemic lupus erythematosus (SLE), the density of cell surface antigens was measured after immunofluorescent staining in a cell sorter. The densities of CD3, CD4, CD5, CD8 and sIgM lymphocyte antigens were the same on patients' lymphocytes as on lymphocytes from healthy subjects. The intensity of HLA-DR immunofluorescence was found to be decreased on patients' monocytes, while the expression of HLA-DR on lymphocytes of patients with SLE hardly differed from that in healthy subjects. Pretreatment of normal mononuclear cells with patients' sera free from immune complexes decreased the binding of anti-HLA-DR antibody to normal monocytes, but it hardly caused alteration on lymphocytes. After culturing, the expression of HLA-DR antigen on patients' monocytes became the same as on normal cells. A causal role of anti-HLA-DR autoantibodies is suggested and discussed.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Antigens,Differentiation Antigens,Surface Autoantibodies Flow Cytometry Fluorescent Antibody Technique HLA Antigens Human Hungary Immunoglobulins,Surface immunology Leukocytes,Mononuclear Lupus Erythematosus,Systemic Lymphocytes Monocytes
Megjelenés:	Immunology Letters. - 15 : 3 (1987), p. 243-247. -
További szerzők:	Surányi Péter Damjanovich Sándor (1936-2017) (biofizikus)
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