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001-es BibID:	BIBFORM004699
Első szerző:	Bacsó Zsolt (biofizikus)
Cím:	INF-gamma rearranges membrane topography of MHC-I and ICAM-1 in colon carcinoma cells / Bacso, Z., Bene, L., Damjanovich, L., Damjanovich, S.
Dátum:	2002
Megjegyzések:	Flow-cytometric fluorescence energy transfer (FCET) measurements between fluorescently labeled cell surface MHC-I and ICAM-1 molecules indicated similar receptor patterns in the plasma membrane of interferon-gamma (INF-gamma)-treated colon carcinoma cells as those observed earlier at the surface of lymphoid cells. INF-gamma activation significantly increased the density of MHC-I and ICAM-1 proteins in the membrane. This increase in receptor density was accompanied by decreased proximity level of the homo-associated MHC-I receptors. Hetero-association of MHC-I and ICAM-1 molecules was increased by INF-gamma treatment. INF-gamma changed neither hetero- nor homo-association of transferrin receptors. By staining the sphingomyelin/cholesterol-enriched lipid microdomains with fluorescently labeled cholera toxin B subunit, we found an increase in the amount of lipid-raft associated G(M1)-gangliosides due to INF-gamma treatment. Confocal microscopic results and FCET measurements show that MHC-I and ICAM-1 are components of G(M1)-ganglioside containing lipid-rafts and also support an increase in the size of these lipid-rafts upon INF-gamma treatment.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Carcinoma Cell Membrane chemistry Cholera Toxin Colonic Neoplasms drug effects Energy Transfer Flow Cytometry Fluorescein-5-isothiocyanate Fluorescence G(M1) Ganglioside Histocompatibility Antigens Class I Human Hungary Intercellular Adhesion Molecule-1 Interferon Type II Membrane Microdomains metabolism Microscopy,Confocal pathology pharmacology Protein Binding Receptors,Cell Surface Receptors,Transferrin Support,Non-U.S.Gov't Tumor Cells,Cultured
Megjelenés:	Biochemical and Biophysical Research Communications. - 290 : 2 (2002), p. 635-640. -
További szerzők:	Bene László (1963-) (biofizikus) Damjanovich László (1960-) (általános sebész) Damjanovich Sándor (1936-2017) (biofizikus)
Internet cím:	DOI elektronikus változat
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