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001-es BibID:	BIBFORM004946
Első szerző:	Jenei Attila (biofizikus)
Cím:	HLA class I and II antigens are partially co-clustered in the plasma membrane of human lymphoblastoid cells / Jenei, A., Varga, S., Bene, L., Matyus, L., Bodnar, A., Bacso, Z., Pieri, C., Gaspar, R., Farkas, T., Damjanovich, S.
Dátum:	1997
ISSN:	0027-8424
Megjegyzések:	Major histocompatibility complex (MHC) class II molecules displayed clustered patterns at the surfaces of T (HUT-102B2) and B (JY) lymphoma cells characterized by interreceptor distances in the micrometer range as detected by scanning force microscopy of immunogold-labeled antigens. Electron microscopy revealed that a fraction of the MHC class II molecules was also heteroclustered with MHC class I antigens at the same hierarchical level as described by the scanning force microscopy data, after specifically and sequentially labeling the antigens with 30- and 15-nm immunogold beads. On JY cells the estimated fraction of co-clustered HLA II was 0.61, whereas that of the HLA I was 0.24. Clusterization of the antigens was detected by the deviation of their spatial distribution from the Poissonian distribution representing the random case. Fluorescence resonance energy transfer measurements also confirmed partial co-clustering of the HLA class I and II molecules at another hierarchical level characterized by the 2- to 10-nm Forster distance range and providing fine details of the molecular organization of receptors. The larger-scale topological organization of the MHC class I and II antigens may reflect underlying membrane lipid domains and may fulfill significant functions in cell-to-cell contacts and signal transduction.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Cell Membrane Energy Transfer Fluorescence Histocompatibility Antigens Class I Histocompatibility Antigens Class II Human Hungary immunology Lymphocytes Major Histocompatibility Complex Microscopy Microscopy, Electron Signal Transduction ultrastructure
Megjelenés:	Proceedings of the National Academy of Sciences of the United States of America. - 94 : 14 (1997), p. 7269-7274. -
További szerzők:	Varga Sándor (1943-) (biofizikus) Bene László (1963-) (biofizikus) Mátyus László (1956-) (biofizikus) Dóczy-Bodnár Andrea (1970-) (biofizikus) Bacsó Zsolt (1963-) (biofizikus) Pieri, Carlo Gáspár Rezső (1944-) (biofizikus) Farkas Tibor (kutató) Damjanovich Sándor (1936-2017) (biofizikus)
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001-es BibID:	BIBFORM043991
Első szerző:	Pieri, Carlo
Cím:	Bretylium differentiates between distinct signal transducing pathways in human lymphocytes / Pieri, C., Bacso, Z., Recchioni, R., Moroni, F., Balazs, M., Gaspar, R., Damjanovich, S.
Dátum:	1993
ISSN:	0006-291X
Megjegyzések:	The selection of signal transducing pathways of T cells depends on the type of triggers. Antigens, antibodies or lectins induce the T cell receptor-CD3 operated pathway, and IL-2 transmits its activation signal via the IL-2 receptor. It has been demonstrated that bretylium, a quaternary ammonium ion, can significantly inhibit the first pathway at the same dose range that stimulates cell activation through the IL-2 receptor system. In the light of the different complexity of the two pathways at the plasma membrane level, and the non-toxic and reversible behavior of the drug, it is suggested that the bretylium induced sustained membrane hyperpolarization is responsible for the observation. This finding may open new possibilities in studying the mechanism of different signal transducing pathways.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Biochemical And Biophysical Research Communications. - 190 : 2 (1993), p. 654-659. -
További szerzők:	Bacsó Zsolt (1963-) (biofizikus) Recchioni, Rina Moroni, Fausto Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Gáspár Rezső (1944-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM033278
035-os BibID:	PMID:8588941 WOS:A1995TF18900001
Első szerző:	Vereb György (biofizikus, orvos)
Cím:	Plasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions? / György Vereb, László Matyus, László Bene, György Panyi, Zsolt Bacsó, Margit Balázs, János Matkó, János Szöllősi, Rezső Gáspár, Sándor Damjanovich, Robert E. Dale, Carlo Pieri, Marcel Ameloot
Dátum:	1995
Megjegyzések:	Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban cell surface molecular pattern energy transfer fluorescence flow cytometry transmembrane potential MHC antigen presentation intercellular communication egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal of Molecular Recognition. - 8 : 4 (1995), p. 237-246. -
További szerzők:	Mátyus László (1956-) (biofizikus) Bene László (1963-) (biofizikus) Panyi György (1966-) (biofizikus) Bacsó Zsolt (1963-) (biofizikus) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Matkó János (1952-) (biológus) Szöllősi János (1953-) (biofizikus) Gáspár Rezső (1944-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Dale, Robert E. Pieri, Carlo Ameloot, Marcel
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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