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001-es BibID:	BIBFORM019005
Első szerző:	Iacovino, Michelina
Cím:	HoxA3 is an apical regulator of haemogenic endothelium / Iacovino Michelina, Chong Diana, Szatmari Istvan, Hartweck Lynn, Rux Danielle, Caprioli Arianna, Cleaver Ondine, Kyba Michael
Dátum:	2011
ISSN:	1465-7392
Megjegyzések:	During development, haemogenesis occurs invariably at sites of vasculogenesis. Between embryonic day (E) 9.5 and E10.5 in mice, endothelial cells in the caudal part of the dorsal aorta generate haematopoietic stem cells and are referred to as haemogenic endothelium. The mechanisms by which haematopoiesis is restricted to this domain, and how the morphological transformation from endothelial to haematopoietic is controlled are unknown. We show here that HoxA3, a gene uniquely expressed in the embryonic but not yolk sac vasculature, restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces reversion of the earliest haematopoietic progenitors into CD41-negative endothelial cells. This reversible modulation of endothelial-haematopoietic state is accomplished by targeting key haematopoietic transcription factors for downregulation, including Runx1, Gata1, Gfi1B, Ikaros, and PU.1. Through loss-of-function, and gain-of-function epistasis experiments, and the identification of antipodally regulated targets, we show that among these factors, Runx1 is uniquely able to erase the endothelial program set up by HoxA3. These results suggest both why a frank endothelium does not precede haematopoiesis in the yolk sac, and why haematopoietic stem cell generation requires Runx1 expression only in endothelial cells.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok levél
Megjelenés:	Nature Cell Biology. - 13 : 1 (2011), p. 72-78. -
További szerzők:	Chong, Diana Szatmári István (1971-) (biológus) Hartweck, Lynn Rux, Danielle Caprioli, Arianna Cleaver, Ondine Kyba, Michael
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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