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001-es BibID:	BIBFORM046775
035-os BibID:	PMID:15256976
Első szerző:	Lakatos Péter (Semmelweis Egyetem)
Cím:	Insulin-like growth factor I gene microsatellite repeat, collagen type Ialpha1 gene Sp1 polymorphism, and bone disease in primary biliary cirrhosis / Peter Laszlo Lakatos, Eva Bajnok, Istvan Tornai, Aniko Folhoffer, Andrea Horvath, Peter Lakatos, Andrzej Habior, Ferenc Szalay
Dátum:	2004
ISSN:	0954-691X
Megjegyzések:	BACKGROUND:Genetic factors have been implicated in the pathogenesis of osteoporosis, a common disorder in primary biliary cirrhosis. Insulin-like growth factor I (IGF-I) gene microsatellite repeat polymorphism was found to be associated with osteoporosis in some studies, and collagen-Ialpha1 (COLIA1) Sp1 s allele was associated with lower bone mineral density in primary biliary cirrhosis. IGF-I treatment restored osteopenia and reduced fibrogenesis in experimental cirrhosis. We investigated IGF-I and COLIA1 gene polymorphisms and bone mineral density in Hungarian primary biliary cirrhosis patients.PATIENTS AND METHODS:Seventy female patients with primary biliary cirrhosis were enrolled (mean age 57.6 years, range 37-76 years; all anti-mitochondrial antibody M2-positive; stage II-IV). One hundred and thirty-nine age-matched female subjects served as controls (mean age 55.9 years, range 43-72 years). COLIA1 and IGF-I polymorphisms were determined by polymerase chain reaction. Bone mineral density was measured by dual-energy X-ray absorptiometry in the lumbar spine and femoral neck.RESULTS:The IGF-I was not different between primary biliary cirrhosis patients and controls. The genotype frequency of COLIA1 polymorphism was also not different between primary biliary cirrhosis patients and controls. However, the s allele was significantly less frequent in patients with primary biliary cirrhosis. Osteoporosis was detected in 22 patients. The IGF-I 192/192 genotype was associated with higher femoral-neck z-scores compared with other genotypes.CONCLUSION:In contrast to previous studies, the s allele was less frequent in patients with primary biliary cirrhosis, and its presence was not associated with bone mineral density. Since IGF-I polymorphism was associated with bone mineral density, it may be hypothesised that not COLIA1 but IGF-I together with other genetic and environmental factors may be involved in the complex regulation of bone mineral density in primary biliary cirrhosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Journal of Gastroenterology & Hepatology. - 16 : 8 (2004), p. 753-759. -
További szerzők:	Bajnok Éva Tornai István (1954-) (belgyógyász, gasztroenterológus) Folhoffer Anikó Horváth Andrea Lakatos Péter (belgyógyász) Habior, Andrzej Szalay Ferenc (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM046776
035-os BibID:	PMID:12663228
Első szerző:	Szalay Ferenc (belgyógyász)
Cím:	High serum osteoprotegerin and low RANKL in primary biliary cirrhosis / Ferenc Szalay, Dalma Hegedus, Peter Laszlo Lakatos, Istvan Tornai, Eva Bajnok, Kinga Dunkel, Peter Lakatos
Dátum:	2003
ISSN:	0168-8278
Megjegyzések:	BACKGROUND/AIMS:Osteoprotegerin is decoy receptor for osteoclast activating factor, RANKL, and impairs osteoclast funtion. Since osteoporosis is common in primary biliary cirrhosis (PBC), we investigated osteoprotegerin, RANKL and markers of bone turnover in PBC.METHODS:Serum osteoprotegerin, RANKL, osteocalcin (OC) and C-terminal cross-linking telopeptide of type I collagen (CTX-I) were measured by ELISA in 41 patients with PBC, 16 women with chronic hepatitis C (CHC), and as controls in 44 age-matched healthy and 74 post-menopausal osteopenic otherwise healthy women.RESULTS:Serum osteoprotegerin levels were higher in PBC patients (7.8+/-3.0 pmol/l) than in healthy controls (4.4+/-2.3 pmol/l) and osteopenic women (4.0+/-1.0 pmol/l, P<0.0001 for both). RANKL levels were lower in PBC (0.9+/-1.8 pmol/l, P<0.0001) than in healthy controls (1.3+/-0.5 pmol/l). In CHC both osteoprotegerin (9.7+/-4.2 pmol/l) and RANKL (3.2+/-4.7 pmol/l) were elevated compared to the control groups (P<0.0001, for both). There was a positive correlation between serum osteoprotegerin and OC, CTX-I and AST but not with bone mineral density in PBC.CONCLUSIONS:The mechanisms and role of elevated osteoprotegerin and low RANKL in PBC are unclear, but it might partly represent a compensatory mechanism to negative balance of bone remodeling. High OPG and RANKL levels found in CHC might suggest that inflammatory process in the liver could also contribute to the elevation of osteoprotegerin.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Hepatology. - 38 : 4 (2003), p. 395-400. -
További szerzők:	Hegedűs Dalma Lakatos Péter (Semmelweis Egyetem) Tornai István (1954-) (belgyógyász, gasztroenterológus) Bajnok Éva Dunkel Kinga Lakatos Péter (belgyógyász)
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001-es BibID:	BIBFORM034948
Első szerző:	Szalay Ferenc
Cím:	Serum leptin, soluble leptin receptor, free leptin index and bone mineral density in patients with primary biliary cirrhosis / Ferenc Szalay, Aniko Folhoffer, Andrea Horváth, Timea Csak, Gabor Speer, Zsolt Nagy, Peter Lakatos, Csaba Horváth, Andrzej Habior, István Tornai, Peter Laszlo Lakatos
Dátum:	2005
ISSN:	0954-691X
Megjegyzések:	The pathophysiology of osteoporosis in chronic liver diseases is unknown. Recent data suggest that serum leptin is associated with bone mineral density (BMD). In animal studies leptin was found to be a potent inhibitor of bone formation. We investigated the relationship between serum leptin levels, soluble leptin receptor (sOB-R), free leptin index (FLI) and BMD in patients with primary biliary cirrhosis (PBC). PATIENTS AND METHODS: Ninety-four female patients with PBC were included in this study; 122 healthy women served as controls. Serum leptin levels were measured by radioimmunoassay, sOB-R by enzyme-linked immunosorbent assay. BMD was measured by dual energy X-ray absorptiometry in the lumbar spine and femoral neck. RESULTS: Serum leptin was significantly lower in patients with PBC compared with healthy controls. No difference was found between the body mass index (BMI) of patients and controls. There was a strong positive correlation between leptin and BMI. In PBC no association was found between leptin, sOB-R and liver function tests, histological stages or the presence of osteoporosis. Osteoporosis was present in 38 patients. A positive correlation was found between serum leptin and femoral neck z-score even after adjustment for BMI, whereas serum sOB-R correlated inversely with the serum leptin level. There was no difference in FLI between the subgroups of PBC patients according to the stages of the disease. CONCLUSIONS: We found a lower serum leptin level and a higher sOB-R in patients with PBC, which could not be explained by the difference in BMI. As leptin was associated with BMD, it may be hypothesized that leptin is involved in the complex regulation of bone metabolism in PBC.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban free leptin index hepatic osteopathy leptin osteoporosis primary biliary cirrhosis soluble leptin receptor egyetemen (Magyarországon) készült közlemény
Megjelenés:	European Journal Of Gastroenterology & Hepatology. - 17 : 9 (2005), p. 923-928. -
További szerzők:	Folhoffer Anikó Horváth Andrea Csak Timea Speer Gábor Nagy Zsolt (orvos) Lakatos Péter (belgyógyász) Horváth Csaba (mérnök) Habior, Andrzej Tornai István (1954-) (belgyógyász, gasztroenterológus) Lakatos Péter (Semmelweis Egyetem)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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