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001-es BibID:BIBFORM076633
Első szerző:Ferenci Péter
Cím:Predictive value of FIB-4 and APRI versus METAVIR on sustained virologic response in genotype 1 hepatitis C patients / Peter Ferenci, Rodrigo Aires, Kimberly L. Beavers, Manuela Curescu, Paulo R. Abrão Ferreira, Michael Gschwantler, Stefan Ion, Dominique Larrey, Mojca Maticic, Massimo Puoti, János Schuller, Istvan Tornai, Anna Tusnádi, Diethelm Messinger, Fernando Tatsch, Andrzej Horban
Dátum:2014
ISSN:1936-0533 1936-0541
Megjegyzések:PURPOSE: Advanced liver fibrosis is a negative predictor of virologic response in genotype 1 chronic hepatitis C (CHC) patients. Biopsy, however, is invasive, costly, and carries some risk of complications. METHODS: Using data from the prospective, international cohort study PROPHESYS, we assessed two alternative noninvasive measures of fibrosis, the FIB-4 and AST-to-platelet ratio index (APRI), to predict virologic response in CHC patients. RESULTS: CHC genotype 1, monoinfected, treatment-naive patients prescribed peginterferon alfa-2a (40 KD)/ribavirin in accordance with country-specific legal and regulatory requirements and who had baseline METAVIR, FIB-4, and APRI scores (N = 1,592) were included in this analysis. Patients were stratified according to the baseline METAVIR, FIB-4, or APRI score to assess virologic response [hepatitis C virus (HCV) RNA <50 IU/mL] by week 4 of treatment (rapid virologic response) and 24 weeks after untreated follow-up ]sustained virologic response (SVR)]. Baseline predictors of SVR were explored by multiple logistic regression, and the strength of the association between each fibrosis measure and SVR was evaluated. Both FIB-4 and APRI scores increased with increasing levels of biopsy-assessed fibrosis. The association between FIB-4 and SVR (p < 0.1 ? 10(-30)) was stronger than that between METAVIR (p = 3.86 ? 10(-13)) or APRI (p = 5.48 ? 10(-6)) and SVR. Baseline factors significantly associated with SVR included male gender, lower HCV RNA, lower FIB-4 score, no steatosis, and higher alanine aminotransferase ratio. CONCLUSION: The FIB-4 index provides a valuable, noninvasive measure of fibrosis and can be used to predict virologic response in patients treated with peginterferon alfa-2a (40 KD)/ribavirin.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Hepatology International. - 8 : 1 (2014), p. 83-93. -
További szerzők:Aires, Rodrigo Beavers, Kimberly L. Curescu, Manuela Abrão Ferreira, Paulo R. Gschwantler, Michael Ion, Stefan Larrey, Dominique Maticic, Mojca Puoti, Massimo Schuller János Tornai István (1954-) (belgyógyász, gasztroenterológus) Tusnádi Anna Messinger, Diethelm Tatsch, Fernando Horban, Andrzej
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