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001-es BibID:BIBFORM005985
035-os BibID:PM:3011116
Első szerző:Mátyus László (biofizikus)
Cím:Cyclosporin A depolarizes cytoplasmic membrane potential and interacts with Ca2+ ionophores / László Mátyus, Margit Balázs, Adorján Aszalós, Sally Mulhern, Sándor Damjanovich
Dátum:1986
ISSN:0167-4889
Megjegyzések:Cytoplasmic membrane potential of mouse lymphocytes was determined with flow cytometry and fluorescence spectroscopy using 3,3'-dihexylcarbocyanine iodide (DiOC6(3)). The amount of this lipophilic cation incorporated into the cytoplasmic membrane is dependent upon the transmembrane potential, so the dye is suitable for continuous monitoring of this parameter, under controlled conditions. Membrane potential of the cells was decreased in the presence of cyclosporin A and cyclosporin G in a dose-dependent manner. However, the depolarization caused by Ca2+ ionophores, ionomycin and A23187, was reduced in the presence of cyclosporin A. Electron spin resonance spectroscopy with 5-doxylstearic acid as a probe indicated that cyclosporin A decreased the apparent motional freedom of membrane lipids. These data suggest incorporation of cyclosporin A into the cytoplasmic membrane, causing changes in ion fluxes. The membrane potential change induced by cyclosporin A may have selective biological consequences in certain subpopulations of lymphocytes.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animal
Calcimycin
Carbocyanines
Cell Membrane
Cyclosporins
Dose-Response Relationship,Drug
drug effects
Drug Interactions
Electron Spin Resonance Spectroscopy
Ethers
Flow Cytometry
Fluorescence
Human
Insulin
Ionomycin
Ionophores
Lymphocyte Transformation
Lymphocytes
Membrane Lipids
Membrane Potentials
metabolism
Mice
Mice,Inbred Strains
pharmacology
Quinolines
ultrastructure
Megjelenés:Biochimica et Biophysica Acta (BBA). Molecular Cell Research. - 886 : 3 (1986), p. 353-360. -
További szerzők:Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Aszalos Adorján Mulhern, Sally Damjanovich Sándor (1936-2017) (biofizikus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változa
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