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001-es BibID:	BIBFORM005967
Első szerző:	Damjanovich Sándor (biofizikus)
Cím:	Cytoplasmic membrane potential of mouse lymphocytes is decreased by cyclosporins / Damjanovich, S., Aszalos, A., Mulhern, S., Balazs, M., Matyus, L.
Dátum:	1986
Megjegyzések:	Membrane potential of mouse lymphocytes was investigated in the presence and absence of cyclosporin A (CsA) and cyclosporin G (CsG) by flow cytometry and fluorescence spectroscopy. A carbocyanine dye, dihexyloxacarbocyanine iodide [DIOC6(3)], was applied as a membrane potential probe. A dose-dependent decrease in the membrane potential of T and B lymphocytes was observed in the presence of CsA and CsG. However, pretreatment of lymphocytes with insulin reduced the effect of the cyclosporins. Mobile ionophores, such as valinomycin, ionomycin and A23187 were less effective in changing the membrane potential of lymphocytes in the presence of CsA. The channel forming ionophore, gramicidin or high extra-cellular potassium concentration (160 mM) strongly reduced the membrane potential regardless of the absence or presence the CsA. These observations suggest incorporation of CsA into the cytoplasmic membrane causing changes in ion fluxes. Other reported biochemical effects of CsA may be secondary to the observed membrane potential changes. The membrane potential change induced by CsA may have selective biological consequences in a certain subpopulation of lymphocytes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animal antagonists and inhibitors B-Lymphocytes Cyclosporins drug effects Flow Cytometry Fluorescence Insulin Ionomycin Ionophores Lymphocytes Membrane Potentials Mice Mice,Inbred Strains pharmacology physiology Potassium Spectrometry,Fluorescence Valinomycin
Megjelenés:	Molecular Immunology. - 23 : 2 (1986), p. 175-180. -
További szerzők:	Aszalos Adorján Mulhern, Sally Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Mátyus László (1956-) (biofizikus)
Internet cím:	elektronikus változat Intézményi repozitóriumban (DEA) tárolt változa
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001-es BibID:	BIBFORM006018
Első szerző:	Trón Lajos (biofizikus)
Cím:	On the biophysics of transmembrane signalling / L. Trón, A. Aszalos, M. Balázs, Sally A. Mulhern, J. Szöllösi, S. Damjanovich
Dátum:	1988
Megjegyzések:	Transmembrane signalling involves a number of physical translocations, changes in proximity of membrane elements like receptor subunits, or sequestration of proteins from the membrane. The monitoring of such changes with flow cytometric energy transfer revealed a new putative subunit of the IL-2 receptor and a possible intermolecular interaction between HLA class I and class II antigens. Lateral diffusion of the components of the multi-subunit IL-2 receptor was also followed. Changes in the intracellular pH were considered as a measure of efficient signal transfer in a number of cases. An overview and critical comparison of data is presented in the paper.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Biophysics Cell Membrane Diffusion Energy Transfer HLA Antigens Human Hungary immunology Interleukin-2 physiology Receptors,Interleukin-2 Signal Transduction Support,Non-U.S.Gov't
Megjelenés:	Molecular Immunology. - 25 : 11 (1988), p. 1075-1080. -
További szerzők:	Aszalos Adorján Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Mulhern, Sally Szöllősi János (1953-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus)
Internet cím:	elektronikus változat
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