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001-es BibID:	BIBFORM033271
035-os BibID:	WOS:000168668400003
Első szerző:	Ádám Zsuzsa
Cím:	Liver metastatic ability of human melanoma cell line is associated with losses of chromosomes 4, 9p21-pter and 10p / Zsuzsanna Ádám, Róza Ádány, Andrea Ladányi, József Timár, Margit Balázs
Dátum:	2000
Megjegyzések:	Genetic changes underlying the aggressive progression of human cutaneous melanoma are not completely understood. In order to characterise genetic alterations associated with the metastatic behaviour of this neoplasm we used comparative genomic hybridisation (CGH) in combination with fluorescence in situ hybridisation (FISH) on an experimental metastatic model of three related human melanoma cell lines. Tumour lines were selected based on their various metastatic capacity to liver in immunosuppressed mice. The parental cell line (A2058) was a human amelanotic melanoma cell line, adaptation of this line to in vivo growth as xenograft the HT168 tumour and its cell line was established. After intrasplenic transplantation of HT168 cells into immunosuppressed mice, a highly metastatic variant (HT168-M1) was selected. Several chromosomal aberrations common to all three lines indicating common clonal origin, as well as additional non-shared chromosomal changes were found. The original cell line (A2058) exhibited the highest number of genetic changes. Chromosomal alterations present only in the highly metastatic line (HT168-M1) involved losses on chromosome 4, 9p21.3-pter and 10p. Chromosome copy number patterns and the nature of chromosome 4 loss were further investigated by FISH using different centromeric probes and a chromosome 4 painting probe. According to our CGH and FISH results we assume that alterations present only in the aggressive metastatic subline are associated with the increased - metastatic potential. Our observations further support the hypothesis, based on some recently published data, that certain (so far unidentified) suppressor genes having an important role in tumour progression are located on these chromosomes.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban experimental model FISH and CGH genetic alterations melanoma metastasis egyetemen (Magyarországon) készült közlemény
Megjelenés:	Clinical & experimental metastasis. - 18 : 4 (2000), p. 295-302. -
További szerzők:	Ladányi Andrea Timár József Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM006055
035-os BibID:	PM:2272119
Első szerző:	Timár József
Cím:	Modulation of membrane phenotype, matrix adhesion and microinvasiveness of metastatic tumour cells by HUdR / Timar, J., Pogany, G., Balazs, M., Szollosi, J., Ladanyi, A., Olah, J., Timar, F., Lapis, K., Jeney, A.
Dátum:	1990
Megjegyzések:	The effect of HUdR, proved to be anti-metastatic in vivo, was studied in vitro on cell proliferation, nucleoside uptake, membrane fluidity, expression of galactosylated glycans and proteoglycans in metastatic HM tumour cells. The observed increase in membrane fluidity and the suppression of nucleoside transport were early events of the HUdR action followed by decrease of galactosylated glycan and HSPG expression. However, these changes did not influence the proliferation capacity of the cells at the concentrations studied. As a consequence of the membrane alterations a reduced adhesiveness and spreading on extracellular matrix components was detected. In addition, the HUdR treated HM cells showed reduced capacity to invade fibroblast monolayers in vitro. Based on these observations, HUdR could be the prototype of new anti-metastatic agents acting at the level of tumour-host interaction.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Animal Antimetabolites,Antineoplastic Cell Adhesion Cell Division Cell Membrane chemistry Deoxyuridine diagnostic use drug effects Extracellular Matrix Glycoconjugates Human Hungary immunology In Vitro Membrane Fluidity metabolism Neoplasm Invasiveness Nucleosides pathology pharmacology Phenotype physiology Proteoglycans Research Tritium
Megjelenés:	Cell Biochemistry and Function. - 8 : 4 (1990), p. 211-220. -
További szerzők:	Pogány G. Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Szöllősi János (1953-) (biofizikus) Ladányi A. Oláh J. Timár F. Lapis Károly Jeney A.
Internet cím:	DOI
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