Találati lista | Tudóstér

001-es BibID:	BIBFORM017520
Első szerző:	Paragh György (belgyógyász)
Cím:	Disturbed regulation of cholesterol synthesis in monocytes of obese patients with hypercholesterolemia / Paragh Gy., Balogh Z., Kovacs E., Szabolcs M., Szabó J., Csapó K., Fóris G.
Dátum:	2003
ISSN:	0026-0495
Megjegyzések:	The aim of the present study was to clarify the influence of obesity on the functions of low-density lipoprotein receptors (LDL-R) and 3-hydroxy-3-methylglutarate-coenyzme A (HMG-CoA) reductase both in healthy control subjects and in patients with hypercholesterolemia (HC). Experiments were performed on monocytes of 15 non-obese (C I) and 11 obese (C II) healthy control subjects and on 22 non-obese (HC I) and 26 obese (HC II) patients with HC. [(125)I]LDL was used to determine LDL-R activity by measuring binding and intracellular degradation. The rate of endogenous cholesterol synthesis was measured using [(14)C]acetate incorporation into the cholesterol fraction of monocytes. The binding ability of [(125)I]LDL was identical across all groups. The [(14)C]acetate incorporation in resting monocytes was increased only in obese HC group. The 50-microg/mL LDL protein-induced inhibition of [(14)C]acetate incorporation was significantly diminished (P <.001) in the same group. A strong positive correlation was detected between the [(14)C]acetate incorporation by resting cells and LDL-induced inhibition in all groups except the obese HC group, in which their correlation was negative (P <.001). Furthermore, in the obese HC group, a significant positive correlation was detected between body mass index (BMI) and the basal level of [(14)C]acetate incorporation, whereas a negative correlation was found between BMI and LDL-induced inhibition of [(14)C]acetate incorporation. The present data suggest that in patients with HC the concomitant obesity results in dysregulation of cholesterol homeostasis, which may contribute to the accelerated atherosclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Metabolism-Clinical And Experimental. - 52 : 1 (2003), p. 1-6. -
További szerzők:	Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Kovács E. Marien, Szabolcs Szabó J. Csapó K. Fóris Gabriella (1937-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM017427
Első szerző:	Paragh György (belgyógyász)
Cím:	Specific and scavenger low density lipoprotein receptors involved in the disturbed lipid metabolism of patients with non-insulin-dependent diabetes melitus are independent of obesity / György Paragh, Éva Kovács, Márton Szabolcs, Jenő Szabó, Zoltán Balogh, Péter Kovács, Gabriella Fóris
Dátum:	1998
Megjegyzések:	Comparative studies were performed on monocyte-derived macrophages (MDMs), prepared by a 72-hour incubation of blood monocytes obtained from patients with non-insulin-dependent diabetes mellitus (NIDDM) and age-matched obese and non-obese controls. The MDMs, after a 72-hour culturing, expressed both specific and scavenger low-density lipoprotein (LDL) receptors on their surfaces. To study the binding capacity of both receptor types, [125I]LDL and [125I] acetylated LDL (acLDL) were applied to cells and the labeled ligands were then monitored to estimate the rate of intracellular degradations. The LDL-induced inhibition of endogenous cholesterol synthesis and the acLDL-triggered apolipoprotein (apo) E secretion were also studied, as the biological marker of receptor activation. The results indicate that the binding capacities of both specific and scavenger LDL receptors were not reduced in MDMs of diabetic patients. However, the intracellular degradation after LDL incorporation was decreased. The LDL-induced inhibition of cholesterol synthesis and the acLDL-transmitted apo E secretion were also found to be decreased in the MDMs of patients with NIDDM as compared with the obese and non-obese control groups. The NIDDM-induced impaired signal transduction of both specific and scavenger LDL receptors suggests an unclarified functional alteration of both receptor structures
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Metabolism - Clinical And Experimental. - 47 : 9 (1998), p. 1070-1074. -
További szerzők:	Kovács Éva Szabolcs Márton Szabó Jenő (belgyógyász, endocrinologus) Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Fóris Gabriella (1937-) (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: