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001-es BibID:BIBFORM017520
Első szerző:Paragh György (belgyógyász)
Cím:Disturbed regulation of cholesterol synthesis in monocytes of obese patients with hypercholesterolemia / Paragh Gy., Balogh Z., Kovacs E., Szabolcs M., Szabó J., Csapó K., Fóris G.
Dátum:2003
ISSN:0026-0495
Megjegyzések:The aim of the present study was to clarify the influence of obesity on the functions of low-density lipoprotein receptors (LDL-R) and 3-hydroxy-3-methylglutarate-coenyzme A (HMG-CoA) reductase both in healthy control subjects and in patients with hypercholesterolemia (HC). Experiments were performed on monocytes of 15 non-obese (C I) and 11 obese (C II) healthy control subjects and on 22 non-obese (HC I) and 26 obese (HC II) patients with HC. [(125)I]LDL was used to determine LDL-R activity by measuring binding and intracellular degradation. The rate of endogenous cholesterol synthesis was measured using [(14)C]acetate incorporation into the cholesterol fraction of monocytes. The binding ability of [(125)I]LDL was identical across all groups. The [(14)C]acetate incorporation in resting monocytes was increased only in obese HC group. The 50-microg/mL LDL protein-induced inhibition of [(14)C]acetate incorporation was significantly diminished (P <.001) in the same group. A strong positive correlation was detected between the [(14)C]acetate incorporation by resting cells and LDL-induced inhibition in all groups except the obese HC group, in which their correlation was negative (P <.001). Furthermore, in the obese HC group, a significant positive correlation was detected between body mass index (BMI) and the basal level of [(14)C]acetate incorporation, whereas a negative correlation was found between BMI and LDL-induced inhibition of [(14)C]acetate incorporation. The present data suggest that in patients with HC the concomitant obesity results in dysregulation of cholesterol homeostasis, which may contribute to the accelerated atherosclerosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Metabolism-Clinical And Experimental. - 52 : 1 (2003), p. 1-6. -
További szerzők:Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Kovács E. Marien, Szabolcs Szabó J. Csapó K. Fóris Gabriella (1937-) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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