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1.

001-es BibID:BIBFORM055377
Első szerző:Fóris Gabriella (belgyógyász)
Cím:Altered Postreceptor Signal Transduction of Formyl-Met-Leu-Phe Receptors in Polymorphonuclear Leukocytes of Patients with Non-Insulin-Dependent Diabetes Mellitus / Gabriella Fóris, György Paragh, Balázs Dezső, Tamás Keresztes, Zoltán Balogh, Jenő Szabó
Dátum:1998
ISSN:0090-1229
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Clinical Immunology and Immunopathology. - 86 : 1 (1998), p. 95-101. -
További szerzők:Paragh György (1953-) (belgyógyász) Dezső Balázs (1951-) (pathológus) Keresztes Tamás Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Szabó Jenő (belgyógyász, endocrinologus)
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2.

001-es BibID:BIBFORM027720
Első szerző:Kárpáti István (belgyógyász, nephrológus)
Cím:Disturbed LDL and scavenger receptor functions in monocytes from chronic haemodialysed patients / István Kárpáti, György Paragh, Éva Kovács, Zoltán Balogh, Márton Szabolcs, Jenő Szabó, György Kakuk, Gabriella Fóris
Dátum:1999
Megjegyzések:BACKGROUND: The most frequent complication in patients with end-stage renal failure on chronic haemodialysis (HD) treatment is atherosclerosis, i.e. the different forms of heart and vascular diseases. The complete disorder of serum lipid and lipoprotein patterns is well demonstrated, whereas our knowledge about the low-density lipoprotein (LDL) and scavenger receptor expression and function are poorly understood. METHODS: In our current work, LDL and scavenger receptor expression and functions were simultaneously studied in monocytes obtained from 15 healthy male control subjects and from 11 chronic HD male patients applied with (125)I-labelled LDL, isolated from healthy volunteers. To study the scavenger LDL receptors, labelled acetylated LDL (acLDL) was used. RESULTS: LDL binding to the monocytes of the HD-group was found to be decreased in comparison to that of the controls. As a result, the 50 microg LDL protein-induced inhibition of endogenous cholesterol synthesis was also diminished. In contrast, acLDL binding was greatly increased, though it could trigger only a low apoE synthesis. Consequently the number of cholesterol inclusions in monocytes was increased. CONCLUSIONS: The disturbed expression and function of LDL and scavenger receptors both may play significant roles in pathogenesis of cardiovascular complications in chronic HD patients. Based on our present results, it can be assumed that dysfunction of scavenger receptors is at the centre of cardiovascular complications of HD patients with renal failure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Nephrology, Dialysis, Transplantation. - 14 : 11 (1999), p. 2664-2668. -
További szerzők:Paragh György (1953-) (belgyógyász) Kovács Éva Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Szabolcs Márton Szabó Jenő (belgyógyász, endocrinologus) Kakuk György (1938-2018) (belgyógyász) Fóris Gabriella (1937-) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM017427
Első szerző:Paragh György (belgyógyász)
Cím:Specific and scavenger low density lipoprotein receptors involved in the disturbed lipid metabolism of patients with non-insulin-dependent diabetes melitus are independent of obesity / György Paragh, Éva Kovács, Márton Szabolcs, Jenő Szabó, Zoltán Balogh, Péter Kovács, Gabriella Fóris
Dátum:1998
Megjegyzések:Comparative studies were performed on monocyte-derived macrophages (MDMs), prepared by a 72-hour incubation of blood monocytes obtained from patients with non-insulin-dependent diabetes mellitus (NIDDM) and age-matched obese and non-obese controls. The MDMs, after a 72-hour culturing, expressed both specific and scavenger low-density lipoprotein (LDL) receptors on their surfaces. To study the binding capacity of both receptor types, [125I]LDL and [125I] acetylated LDL (acLDL) were applied to cells and the labeled ligands were then monitored to estimate the rate of intracellular degradations. The LDL-induced inhibition of endogenous cholesterol synthesis and the acLDL-triggered apolipoprotein (apo) E secretion were also studied, as the biological marker of receptor activation. The results indicate that the binding capacities of both specific and scavenger LDL receptors were not reduced in MDMs of diabetic patients. However, the intracellular degradation after LDL incorporation was decreased. The LDL-induced inhibition of cholesterol synthesis and the acLDL-transmitted apo E secretion were also found to be decreased in the MDMs of patients with NIDDM as compared with the obese and non-obese control groups. The NIDDM-induced impaired signal transduction of both specific and scavenger LDL receptors suggests an unclarified functional alteration of both receptor structures
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Metabolism - Clinical And Experimental. - 47 : 9 (1998), p. 1070-1074. -
További szerzők:Kovács Éva Szabolcs Márton Szabó Jenő (belgyógyász, endocrinologus) Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Fóris Gabriella (1937-) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM017499
Első szerző:Paragh György (belgyógyász)
Cím:Altered signal pathway in angiotensin II-stimulated neutrophils of patients with hypercholesterolemia / György Paragh, Jenő Szabó, Éva Kovács, Tamás Keresztes, István Kárpáti, Zoltán Balogh, Dénes Páll, Gabriella Fóris
Dátum:2002
ISSN:0898-6568
Megjegyzések:Angiotensin II (AII) in 1-10 nM concentrations has an in vivo immunostimulating effect on human neutrophils. The release of superoxide anions and leukotrienes (LTs) is significantly increased by 10 nM AII-stimulated neutrophils of patients with hypercholesterolaemia (HCH). These oxidizing agents may be involved in the damage of vessel walls, i.e., in atherosclerotic plaque formation. To clarify the receptor types and signal pathways in neutrophils of healthy controls and patients, inositol trisphosphate (IP(3)) production and Ca(2+) signalling were studied. Neutrophils were pretreated before AII stimulation with different inhibitory drugs. In control cells, the stimulation occurred predominantly through pertussis toxin-sensitive, type angiotensin 1 receptors. This induced IP(3) production and Ca(2+) signalling from intracellular pools. In neutrophils of hypercholesterolaemic patients, the enhanced release of oxidizing agents was dependent more on type angiotensin 2 than type angiotensin 1 receptors. After stimulation, there was no IP(3) production detected. The Ca(2+) signalling was lower than in control cells and was dependent on extracellular Ca(2+).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Cellular Signalling. - 14 : 9 (2002), p. 787-792. -
További szerzők:Szabó Jenő (belgyógyász, endocrinologus) Kovács Éva Keresztes Tamás Kárpáti István (1955-) (belgyógyász, nephrológus) Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Páll Dénes (1967-) (belgyógyász, kardiológus) Fóris Gabriella (1937-) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM017442
Első szerző:Paragh György (belgyógyász)
Cím:Altered signal pathway in granulocytes from patients with hypercholesterolemia / Paragh Gy., Kovács É., Seres I., Keresztes T., Balogh Z., Szabó J., Teichmann F., Fóris G.
Dátum:1999
Megjegyzések:In the present study the signal transduction of the formyl-Met-Leu-Phe receptor was studied in granulocytes obtained from control subjects and patients with elevated low density lipoprotein levels. According to our results, 10 nm formyl-Met-Leu-Phe in control cells activates phospholipase C inducing a pronounced inositol phosphate production followed by a Ca(2+) signal from intracellular pools. The pertussis toxin-sensitive O(2)(-) generation and leukotriene synthesis were moderate. In contrast, in granulocytes from hypercholesterolemic patients, formyl-Met-Leu-Phe triggered an intensive pertussis toxin-insensitive oxidative burst and leukotriene synthesis. The inositol trisphosphate and Ca(2+) signals were decreased significantly in granulocytes of hypercholesterolemic patients and seem to be dependent on the extracellular Ca(2+) content. Furthermore, in the resting granulocytes of hypercholesterolemic patients the [Ca(2+)]i and the membrane-bound protein kinase C activity were higher than in controls, the time of normalization after the low Ca(2+) signal was delayed, while the membrane fluidity was decreased. Our results suggest that in these ex vivo experiments, the high level of circulating low density lipoprotein in patients can affect the membrane composition of granulocytes leading to altered signal transduction by the formyl-Met-Leu-Phe receptor, to altered Ca(2+) pump-activity, and protein kinase C translocation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Lipid Research. - 40 : 9 (1999), p. 1728-1733. -
További szerzők:Kovács Éva Seres Ildikó (1954-) (biokémikus) Keresztes Tamás Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Szabó Jenő (belgyógyász, endocrinologus) Teichmann Farkas Fóris Gabriella (1937-) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM017419
Első szerző:Paragh György (belgyógyász)
Cím:Treatment possibility of hypercholesterolaemia associated with hypertriglyceridaemia / Paragh Gy., Balogh Z., Boda J., Kovács P., Kárpáti I., Szabó J., Leövey A.
Dátum:1997
Megjegyzések:Thirty patients were investigated with hyperlipoproteinaemia, 15 patients with non-insulin dependent diabetes mellitus (NIDDM) and 15 with primary hyperlipoproteinaemia. The patients took 250 mg acipimox (5-metyl-pyrazine-carboxylic acid 4-oxide) 3 times per day for 2 months. Serum examinations were performed before and after 1 and 2 months of acipimox administration. After treatment the cholesterol and triglyceride levels decreased in both groups. Patients with NIDDM had 11% increase of high density lipoprotein-cholesterol (HDL-C) level at the end of the first, and 18% increase at the end of the second month, while patients with primary hyperlipoproteinaemia did not change significantly. The low density lipoprotein (LDL) level did not change significantly in either groups of patients. The apolipoprotein A 1 (apo A 1) levels increased significantly during the second month of acipimox administration. Uric acid levels decreased in both groups, but significant change could be detected mainly in the NIDDM group. Serum glucose level did not change in the non-diabetic patients, while it decreased significantly in the NIDDM group.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Megjelenés:Acta Biologica Hungarica. - 48 : 3 (1997), p. 359-367. -
További szerzők:Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Boda Judit (belgyógyász, endokrinológus) Kovács Péter (1947-) (belgyógyász, kardiológus, klinikai farmakológus) Kárpáti István (1955-) (belgyógyász, nephrológus) Szabó Jenő (belgyógyász, endocrinologus) Leövey András (1926-) (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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