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001-es BibID:	BIBFORM053374
Első szerző:	Gáspár Krisztián (bőrgyógyász)
Cím:	Regulatory T-cell subsets with acquired functional impairment : important indicators of disease severity in atopic dermatitis / Krisztián Gáspár, Sándor Baráth, Georgina Nagy, Gábor Mócsai, Edit Gyimesi, Péter Szodoray, Beatrix Irinyi, Margit Zeher, Éva Remenyik, Andrea Szegedi
Dátum:	2015
ISSN:	0001-5555
Megjegyzések:	Our aim was to assess whether the presence of highly active effector T-cells in atopic dermatitis (AD) is associated with changes in the number and/or function of regulatory T-cells (Tregs). Flow cytometry was utilised to determine the percentage of CD4+CD25brightCD127-/lowFOXP3+ and skin-homing CLA+CD4+CD25brightFOXP3+ Tregs in healthy controls and AD patients. The correlation between disease severity and Treg percentages was estimated. Treg suppressor activity and cell proliferation were measured after T-cell stimulation. Significantly increased percentages of Tregs were found in AD patients compared to healthy individuals, and significant correlation between the frequency of Tregs and disease severity was also detected. The otherwise normal suppressor activity of Tregs decreased in the presence of Staphylococcus enterotoxin B (SEB). In conclusion, the continuous presence of SEB can trigger an acquired functional impairment of Tregs in AD patients and the correlation between the increased frequency of Tregs and disease severity supports their important role in AD pathogenesis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Acta Dermato-Venereologica. - 95 : 2 (2015), p. 151-155. -
További szerzők:	Baráth Sándor (1977-) (biológus) Nagy Georgina (1980-) (orvosbiológus) Mócsai Gábor (1984-) (PhD hallgató) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Szodoray Péter (1973-) (belgyógyász, orvos) Irinyi Beatrix (1972-) (bőrgyógyász, allergológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Remenyik Éva (1956-) (bőrgyógyász) Szegedi Andrea (1964-) (bőrgyógyász)
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001-es BibID:	BIBFORM013668
035-os BibID:	(cikkazonosító)239
Első szerző:	Gáspár Krisztián (bőrgyógyász)
Cím:	Frequency and function of CD4+CD25+FOXP3+ regulatory T cells in atopic dermatitis / Krisztián Gáspár, Sándor Baráth, Georgina Nagy, Edit Gyimesi, Sándor Sipka, Margit Zeher, Éva Remenyik, Andrea Szegedi
Dátum:	2010
ISSN:	0022-202X 1523-1747
Megjegyzések:	Atopic dermatitis (AD) is a chronic infl ammatory skin disease resulted partly of type I andtype IV hypersensitivity reactions triggered by T helper 2 (Th2) cells. The explanations behindthe Th2 dominance in the disease are still controversial. We addressed the question whetherthe Th2 cell domination is associated with a reduction and/or functional impairment ofCD4+CD25+FOXP3+ regulatory T cells (Treg) essential for the maintenance of Th1- Th2balance. Peripheral blood of AD patients with severe clinical symptoms and extremely highserum IgE levels (>2000 U/ml) were investigated. Flow cytometry was utilised to determinethe percentage of CD4+CD25brightFOXP3+ Tregs and CLA+CD4+CD25brightFOXP3+ Tregs in thesamples of AD patients and healthy controls. For detection of suppressor activity of CD4+CD25+Tregs, they were cocultured with CD4+CD25- effector T cells, and for T cell stimulation,anti-CD3/CD28 microbeads were applied alone or with Staphylococcus Enterotoxin B(SEB). The proliferation of the cells was measured by EZ4U colorimetric cell proliferationassay. Signifi cantly increased number of CD4+CD25brightFOXP3+ Tregs and also of CLA+CD4+CD25brightFOXP3+ Tregs were found in the peripheral blood of AD patients compared tohealthy individuals. The degree of suppressor activity of CD4+CD25+ regulatory T cells weredecreased in both anti-CD3/CD28 and SEB stimulated subgroups compared to control. Ourdata suggest coincidently with the literature that the pathogenesis of AD cannot be explainedwith the absence of CD4+CD25+FOXP3+ Treg cells, moreover the number of these cells isincreased in the peripheral blood. At the same time the function of Tregs may be impaired.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk Atopic dermatitis CD4+CD25+FOXP3+
Megjelenés:	The Journal of Investigative Dermatology. - 130 : Suppl. 2 (2010), p. S40. -
További szerzők:	Baráth Sándor (1977-) (biológus) Nagy Georgina (1980-) (orvosbiológus) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Sipka Sándor (1945-) (laboratóriumi szakorvos) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Remenyik Éva (1956-) (bőrgyógyász) Szegedi Andrea (1964-) (bőrgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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