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001-es BibID:BIBFORM044317
Első szerző:Markó Lóránt (bőrgyógyász)
Cím:Keratinocyte ATP binding cassette transporter expression is regulated by ultraviolet light / Lóránt Markó, György Paragh, Péter Ugocsai, Alfred Boettcher, Thomas Vogt, Petra Schling, Attila Balogh, Victoria Tarabin, Evelyn Orsó, Norbert Wikonkál, József Mandl, Éva Remenyik, Gerd Schmitz
Dátum:2012
ISSN:1011-1344
Megjegyzések:Many ATP binding cassette (ABC) transporters are important regulators of lipid homeostasis and have been implicated in keratinocyte lipid transport. Ultraviolet (UV) light exposure is a known epidermal stressor, which amongst other effects causes lipid alterations and defective lamellar body biogenesis. To elucidate the background of these lipid changes we studied the effect of UVB light on ABC transporter expression. The effect of UVB treatment on the levels of 47 known human ABC transporter mRNAs was analyzed in normal human epidermal keratinocytes. Immunoblots and promoter assays were carried out for ABCA1 and ABCG1. The mRNA levels of cholesterol transport regulators ABCA1 and ABCG1 were markedly downregulated by UVB, parallel to the lamellar ichthyosis related glucosylceramide transporter ABCA12 and the suspected sphingosine-1-phosphate and cholesterol sulfate transporter ABCC1. The long but not the short alternative splice variant of the ABCF2 was found to be markedly upregulated rapidly after UVB irradiation. Immunoblot confirmed ABCA1 and ABCG1 protein downregulation, and luciferase assays showed suppression of their promoters by UVB. These proteins mostly transport lipids, which account for the integrity of the epidermal barrier; therefore our findings on the UVB regulation of ABC transporters may explain the appearance of barrier dysfunction after UVB exposure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Keratinocyte
Lipid transport
ABC transporter
UVB
Epidermal barrier
Megjelenés:Journal of Photochemistry índ Photobiology B-Biology. - 116 (2012), p. 79-88. -
További szerzők:Paragh György Jr. (1978-) (bőrgyógyász) Ugocsai Péter Boettcher, Alfred Vogt, Thomas Schling, Petra Balogh Attila (bőrgyógyász) Tarabin, Victoria Orsó Evelyn Wikonkál Norbert (1968-) (bőrgyógyász) Mandl József Remenyik Éva (1956-) (bőrgyógyász) Schmitz, Gerd
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001-es BibID:BIBFORM011489
Első szerző:Paragh György Jr. (bőrgyógyász)
Cím:Whole genome transcriptional profiling identifies novel differentiation regulated genes in keratinocytes / Paragh G., Ugocsai P., Vogt T., Schling P., Kel A. E., Tarabin V., Liebisch G., Orsó E., Markó L., Balogh A., Köbling T., Remenyik E., Wikonkál N. M., Mandl J., Farwick M., Schmitz G.
Dátum:2009
Megjegyzések:Keratinocyte differentiation plays a pivotal role in the epidermal barrier. Single keratinocyte differentiation genes have already been studied, but many important constituents of this process may have been missed so far. Gene expression profiling by microarray was carried out in cultured normal human epidermal keratinocytes undergoing confluence-induced differentiation to find novel differentiation genes. Candidate gene lists were established and genes of potential dermatological interest were validated by quantitative reverse transcription polymerase chain reaction and immunohistochemical analysis. Some of these points lead to the identification of counter-regulation of heme oxygenase and biliverdin reductase as well as glutaredoxin and glutathione reductase indicative of potential novel redox signaling in differentiating human keratinocytes. Others indicate a strong concert down-regulation of interleukin-1 signaling at previously unidentified levels during keratinocyte differentiation. We believe that identified genes contribute to a more comprehensive understanding of the complicated epidermal differentiation process and lead to better understanding of dermatological diseases.
Tárgyszavak:Orvostudományok Elméleti orvostudományok szerkesztői levél
Megjelenés:Experimental Dermatology. - 19 : 3 (2009), p. 297-301. -
További szerzők:Ugocsai Péter Vogt, Thomas Schling, Petra Kel, Alexander E. Tarabin, Victoria Liebisch, Gerhard Orsó Evelyn Markó Lóránt (1980-) (bőrgyógyász) Balogh Attila (bőrgyógyász) Köbling Tamás (1978-) (belgyógyász) Remenyik Éva (1956-) (bőrgyógyász) Wikonkál Norbert, M. Mandl József Farwick, Mike Schmitz, Gerd
Internet cím:DOI
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