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001-es BibID:bibEBI14316
Első szerző:Wikonkál Norbert (bőrgyógyász)
Cím:bcl-2 vs p53 protein expression and apoptotic rate in human nonmelanoma skin cancers / Wikonkál, N., Berg, R. J. W., van Haselen, C. W., Horkay, I., Remenyik, É., Bégány, Á., Hunyadi, J., van Vloten, W. A., de Gruijl, F. R.
Dátum:1997
Megjegyzések:A failure in the apoptotic response after severe genomic damage could facilitate cell transformation and tumor development, and a constitutive overexpression of either p53 or bcl-2 protein in nonapoptotic tumor cells could signify a defective bax-mediated apoptosis. OBJECTIVES: To investigate whether a negative correlation occurs between these 2 proteins in nonmelanoma skin cancer and whether overexpression of either protein is associated with a low rate of spontaneous apoptosis. DESIGN: Immunohistochemical study of nonmelanoma skin cancer archive material. SETTING: University referral center. PATIENTS: White patients with tumors on sun-exposed skin areas (ie, 17 basal cell carcinomas and 22 squamous cell carcinomas). MAIN OUTCOME MEASURES: Positivity for p53 and bcl-2 were scored semiquantitatively on 4 levels, and the percentages of apoptotic cells were determined. RESULTS: A significant negative correlation between p53 and bcl-2 expression was found in the basal cell carcinomas, but not in the squamous cell carcinomas, largely attributable to the low level of bcl-2 staining in the squamous cell carcinomas. Squamous cell carcinomas have a significantly higher number of apoptotic cells than basal cell carcinomas: 1.1% vs 0.6%, respectively. This spontaneous apoptosis decreases with increasing bcl-2 (in basal cell carcinoma), whereas it does not appear to be related to p53 level expression. CONCLUSIONS: These results indicate that a disturbance in either p53 or bcl-2 suffices to enhance skin tumor formation by suppressing apoptosis; bcl-2 appears to reduce the rate of spontaneous apoptosis, but an aberrant p53 expression does not, and this factor may solely affect the apoptosis from exogenous genotoxicity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Archives of Dermatology. - 133 : 5 (1997), p. 599-602. -
További szerzők:Berg, R. J. W. Haselen, C. W., van Horkay Irén (1938-) (bőrgyógyász, labor szakorvos, kozmetológus) Remenyik Éva (1956-) (bőrgyógyász) Bégány Ágnes (1954-2011) (bőrgyógyász, kozmetológus, klinikai onkológus) Hunyadi János (1943-) (bőrgyógyász, kozmetológus, allergológus) Vloten, W. A., van de Gruijl, F. R.
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