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001-es BibID:	BIBFORM007129
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4 : the possible role for IL-6 and interferon-gamma in vascular inflammation / Szekanecz, Z., Shah, M. R., Pearce, W. H., Koch, A. E.
Dátum:	1994
ISSN:	0065-4299 (Print)
Megjegyzések:	Immunological mechanisms play an important role in the pathogenesis of atherosclerosis and atherosclerotic abdominal aortic aneurysms (AAA). Inflammatory leukocytes invade the vessel wall and produce cytokines which perpetuate the immune events underlying these diseases. Interleukin (IL)-1 beta, IL-8, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1, among others, may play a role in the generation by AAA. The aim of this study was to investigate the possible pathogenetic role of other proinflammatory cytokines, namely IL-2, IL-4, IL-6, and interferon (IFN)-gamma. Enzyme-linked immunosorbent assay of human explant culture supernatants revealed a significant increase in IFN-gamma production by AAA compared to occlusive (atherosclerotic) or normal (NL) aortic explants. IL-6 production was also increased in AAA compared to NL aortic explant supernatants. Neither AAA nor NL aortic tissues produced IL-2 or IL-4 in the same culture system. These results suggest that IL-6, a cytokine involved in T and B lymphocyte activation during inflammation, and IFN-gamma, which stimulates T and B lymphocytes, macrophages, endothelial cells and fibroblasts, may play a role in the pathogenesis of various vascular inflammatory diseases such as AAA.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Aorta, Abdominal Aortic Aneurysm, Abdominal Arteriosclerosis Culture Media, Conditioned Enzyme-Linked Immunosorbent Assay Humans Interferon-gamma Interleukin-2 Interleukin-4 Interleukin-6 Vasculitis
Megjelenés:	Agents and Actions. - 42 : 3-4 (1994), p. 159-162. -
További szerzők:	Shah, M. R. Pearce, W. H. Koch, Alisa E.
Internet cím:	elektronikus változat
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001-es BibID:	BIBFORM007132
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Effect of pentoxifylline on decreased in vitro mononuclear leucocyte chemotaxis in vascular and polysystemic autoimmune diseases / Szekanecz, Z., Szabo, G., Sonkoly, I., Bedo, Z., Szegedi, G.
Dátum:	1991
ISSN:	0065-4299 (Print)
Megjegyzések:	Impaired mononuclear leucocyte (MNL) motility can be found both in vascular and autoimmune diseases. Pentoxifylline (PTX) has a well-known therapeutic effect in vascular diseases, which is based on the rearrangement of blood cell cytoskeleton and thus increased microcirculatory flow. Most data on PTX concern red blood cells and granulocytes so now the effect of PTX on previously decreased MNL migration and chemotaxis was investigated in vitro. The results of MNL chemotaxis studies described here suggest that this drug enhances impaired MNL motility in obliterative atherosclerosis and systemic lupus erythematosus and thus may also be introduced in the treatment of certain polysystemic autoimmune diseases with decreased in vitro MNL chemotaxis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Arteriosclerosis Obliterans Autoimmune Diseases Chemotaxis, Leukocyte Female Humans Lupus Erythematosus, Systemic Male Middle Aged Neutrophils Pentoxifylline Zymosan
Megjelenés:	Agents and Actions. - 33 : 3-4 (1991), p. 254-259. -
További szerzők:	Szabó G. (orvos) Sonkoly Ildikó Bedő Zoltán Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:	elektronikus változat
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