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001-es BibID:BIBFORM040291
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Chemokines in rheumatic diseases / Szekanecz, Z., Szucs, G., Szanto, S., Koch, A. E.
Dátum:2006
ISSN:1389-4501
Megjegyzések:Chemotactic cytokines, termed chemokines, mediate the ingress of leukocytes into the inflamed synovium. In this review, authors discuss the role of the most relevant chemokines and chemokine receptors involved in chronic inflammatory rheumatic diseases. Rheumatoid arthritis was chosen as a prototype to discuss these issues, as the majority of studies on the role of chemokines in inflammatory diseases were carried out in arthritis. However, other rheumatic diseases including systemic lupus erythematosus, systemic sclerosis, Sjögren's syndrome, mixed connective tissue disease, polymyositis/dermatomyositis, antiphospholipid syndrome and systemic vasculitides are also discussed in this context. Apart from discussing the pathogenic role of chemokines and their receptors, authors also review the regulation of chemokine production by other inflammatory mediators, as well as the important relevance of chemokines for antirheumatic therapies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Current Drug Targets. - 7 : 1 (2006), p. 91-102. -
További szerzők:Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szántó Sándor (1968-) (belgyógyász, reumatológus) Koch, Alisa E.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM007118
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Endothelial cells in inflammation and angiogenesis / Szekanecz, Z., Koch, A. E.
Dátum:2005
ISSN:1568-010X (Print)
Megjegyzések:Endothelial cells are involved in leukocyte extravasation underlying inflammation. A number of adhesion molecules play a role in leukocyte-endothelial interactions. New vessel formation, termed angiogenesis, is also crucial for leukocyte extravasation. The outcome of neovascularization is highly dependent on the balance or imbalance between angiogenic mediators and inhibitors. There have been several attempts to therapeutically interfere with the cellular and molecular mechanisms, such as leukocyte-endothelial cell adhesion and angiogenesis. Most studies have been performed using animal models of various types of inflammation, such as arthritis. In addition, a very limited number of human clinical trials gave promising results. In this review, authors summarize the most relevant information on adhesion molecules, as well as angiogenic and angiostatic agents. In addition, further perspectives of anti-adhesive and anti-angiogenic therapy are also discussed. Specific targeting of pathological endothelial function including adhesion and angiogenesis, may be useful for the future management of various inflammatory diseases.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Cell Adhesion
Cell Membrane Permeability
Endothelial Cells
Humans
Inflammation
Neovascularization, Pathologic
Megjelenés:Current Drug Targets. Inflammation and Allergy. - 4 : 3 (2005), p. 319-323. -
További szerzők:Koch, Alisa E.
Internet cím:elektronikus változat
elektronikus változat
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