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001-es BibID:	BIBFORM015914
035-os BibID:	PMID 20036936 PMC2917905
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Chemokines and chemokine receptors in arthritis / Szekanecz, Z., Vegvari, A., Szabo, Z., Koch, A. E.
Dátum:	2010
ISSN:	1945-0524 (Electronic)
Megjegyzések:	Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines. Chemokines may also be either inflammatory or homeostatic, however, these functions often overlap. Anti-chemokine and anti-chemokine receptor targeting may be therapeutically used in the future biological therapy of arthritis. Most data in this field have been obtained from animal models of arthritis as only very few human RA trials have been completed. However, it is very likely that various specific chemokine and chemokine receptor antagonists will be developed and administered to RA patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Arthritis, Rheumatoid/drug therapy/immunology Chemokines/classification/immunology Drug Delivery Systems Gene Expression Regulation/immunology Humans Immunotherapy/methods Neovascularization, Physiologic/immunology Receptors, Chemokine/immunology Synovitis/*immunology
Megjelenés:	Frontiers in Bioscience (Scholar edition). - 2 (2010), p. 153-167. -
További szerzők:	Végvári Anikó (belgyógyász, III. sz. Belgyógyászati Klinika) Szabó Zoltán (1970-) (belgyógyász, reumatológus) Koch, Alisa E.
Internet cím:	elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM007102
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Angiogenesis in rheumatoid arthritis / Szekanecz, Z., Gaspar, L., Koch, A. E.
Dátum:	2005
ISSN:	1093-4715 (Electronic)
Megjegyzések:	Endothelial cells lining the lumina of blood vessels are involved in leukocyte extravasation underlying inflammatory states, such as rheumatoid arthritis (RA). New vessel formation, termed angiogenesis, is also crucial for leukocyte extravasation during inflammatory synovitis. The outcome of neovascularization in the RA synovium is highly dependent on the balance or imbalance between angiogenic mediators and inhibitors. There have been several attempts to therapeutically interfere with the cellular and molecular mechanisms underlying RA-associated neovascularization. Most studies have been performed using animal models of arthritis. In addition, a limited number of human clinical trials gave promising results. In this review, authors summarize some relevant information on those angiogenic and angiostatic agents, which have also been studied in context with RA. In addition, further perspectives of anti-angiogenic therapy in arthritis are also discussed. Specific targeting of angiogenesis may be useful in the future management of various inflammatory, as well as malignant, diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Angiogenesis Inducing Agents Angiogenesis Inhibitors Arthritis, Rheumatoid Cell Adhesion Molecules Humans Neovascularization, Pathologic Synovial Membrane
Megjelenés:	Frontiers in Bioscience. - 10 (2005), p. 1739-1753. -
További szerzők:	Gáspár Levente (1948-) (ortopéd és baleseti sebész) Koch, Alisa E.
Internet cím:	elektronikus változat
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001-es BibID:	BIBFORM007126
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Chemokines and angiogenesis in rheumatoid arthritis / Szekanecz, Z., Pakozdi, A., Szentpetery, A., Besenyei, T., Koch, A. E.
Dátum:	2009
ISSN:	1945-0494 (Print)
Megjegyzések:	In rheumatoid arthritis, chemokines mediate the migration of inflammatory leukocytes into the synovium. Among the four known chemokine families, CXC, CC chemokines and fractalkine seem to be of outstanding importance in this process. Angiogenesis, the formation of new vessels, is also important during the perpetuation of inflammation underlying rheumatoid arthritis. In this review, authors discuss the role of the most important chemokines and chemokine repetors in arthritis-associated neovascularization. The process and regulation of angiogenesis are described in this context as well. Apart from discussing the pathogenic role of chemokines and chemokine receptors in arthritic vessel formation, authors also review the important relevance of chemokines and angiogenesis for therapeutic intervention.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Frontiers in Bioscience (Elite Edition). - 1 (2009), p. 44-51. -
További szerzők:	Pákozdi Angéla Szentpétery Ágnes (1978-) (reumatológus) Besenyei Tímea (1980-) (reumatológus, belgyógyász) Koch, Alisa E.
Internet cím:	elektronikus változat elektronikus változat
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