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001-es BibID:	BIBFORM007072
Első szerző:	Koch, Alisa E.
Cím:	In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis : their role in early and late disease / Koch, A. E., Kronfeld-Harrington, L. B., Szekanecz, Z., Cho, M. M., Haines, G. K., Harlow, L. A., Strieter, R. M., Kunkel, S. L., Massa, M. C., Barr, W. G., Jimenez, S. A.
Dátum:	1993
ISSN:	1015-2008 (Print)
Megjegyzések:	Cytokines and cellular adhesion molecules (CAMs) may play a role in the inflammatory and fibrotic processes underlying systemic sclerosis (SSc). We compared the immunohistological distribution of cytokines and CAMs in skin biopsies from 12 SSc patients and 14 normal (NL) individuals. Among CAMs, vascular cell adhesion molecule-1 (VCAM-1), which mediates leukocyte-endothelial adhesion, showed increased expression on SSc versus NL endothelium and stratum granulosum. P-selectin was up-regulated in SSc versus NL stratum granulosum. The CD44 lymphocyte homing receptor showed the most striking differences between SSc and NL: its expression was increased in SSc stratum granulosum, stratum spinosum, on lymphocytes, and macrophages. Regarding cytokines, interleukin-6 (IL-6) expression was increased on SSc versus NL endothelium and fibroblasts. Tumor necrosis factor-alpha (TNF-alpha) reactivity was more prevalent in SSc than NL stratum granulosum, whereas IL-8 expression was higher on SSc compared to NL endothelium. Some CAMs, such as VCAM-1 and P-selectin, and cytokines, namely TNF-alpha and IL-8, were more commonly found in skin biopsies taken from early (< or = 1 year's duration) SSc, while others, such as IL-6, showed up-regulation in the late stage of the disease. The results suggest that certain CAMs and cytokines may play a differential role in both the early, inflammatory, and the late, fibrotic stage of SSc.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Aged Antigens, CD44 Biopsy Carrier Proteins Cell Adhesion Cell Adhesion Molecules Cytokines Endothelium Female Fibroblasts Humans Immunohistochemistry Interleukin-6 Interleukin-8 Male Middle Aged P-Selectin Platelet Membrane Glycoproteins Receptors, Cell Surface Receptors, Lymphocyte Homing Scleroderma, Systemic Skin Tumor Necrosis Factor-alpha Vascular Cell Adhesion Molecule-1
Megjelenés:	Pathobiology. - 61 : 5-6 (1993), p. 239-246. -
További szerzők:	Kronfeld-Harrington, Lisa B. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Cho, Michael M. Haines, G. Kenneth Harlow, Lisa A. Strieter, Robert M. Kunkel, Steven L. Massa, Mary C. Barr, Walter G. Jimenez, Sergio A.
Internet cím:	elektronikus változat
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001-es BibID:	BIBFORM007127
Első szerző:	Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:	Interleukin-8 and tumor necrosis factor-alpha are involved in human aortic endothelial cell migration : the possible role of these cytokines in human aortic aneurysmal blood vessel growth / Szekanecz, Z., Shah, M. R., Harlow, L. A., Pearce, W. H., Koch, A. E.
Dátum:	1994
ISSN:	1015-2008 (Print)
Megjegyzések:	Angiogenesis, the growth and proliferation of blood vessels, may be important in the pathogenesis of atherosclerosis and thus in human atherosclerotic abdominal aortic aneurysms (AAAs). Endothelial migration or chemotaxis is a vital component of the angiogenic response. Here, human aortic endothelial cells (hAECs) were used to investigate the effect of AAA tissue supernatants on hAEC chemotaxis. AAA tissue conditioned media were found to be chemotactic for hAECs. We have previously shown that the angiogenic cytokines interleukin (IL)-8, and tumor necrosis factor (TNF)-alpha are present in AAAs and normal aortic explant conditioned media. Currently, we have found that basic fibroblast growth factor (bFGF) and platelet-derived growth factor can also be detected in these supernatants. In order to identify whether some of these soluble mediators contributed to the chemotactic activity of these supernatants, conditioned media were preincubated with either neutralizing anti-IL-8, anti-TNF-alpha, anti-bFGF antibodies or control serum. Anti-IL-8 and anti-TNF-alpha significantly inhibited AAA tissue supernatant-induced hAEC chemotaxis (p < 0.05), while anti-bFGF did not (p not significant). These results indicate that IL-8 and TNF-alpha may be important in chemotactic activity for hAECs in vitro and possibly in AAA neovascularization. The abrogation of angiogenesis using neutralizing antibodies may be a future goal in the therapy of certain disease states such as AAA where angiogenesis plays an important role.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Antibodies, Monoclonal Aortic Aneurysm, Abdominal Cell Movement Cells, Cultured Chemotaxis Culture Media, Conditioned Endothelium, Vascular Enzyme-Linked Immunosorbent Assay Fibroblast Growth Factor 2 Humans Interleukin-8 Platelet-Derived Growth Factor Tumor Necrosis Factor-alpha
Megjelenés:	Pathobiology. - 62 : 3 (1994), p. 134-139. -
További szerzők:	Shah, M. R. Harlow, Lisa A. Pearce, W. H. Koch, Alisa E.
Internet cím:	elektronikus változat
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