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001-es BibID:	BIBFORM116830
035-os BibID:	(cikkazonosító)1786 (WoS)001131056200001 (Scopus)85180662724
Első szerző:	Polivka Lőrinc
Cím:	Waning of SARS-CoV-2 Vaccine Effectiveness in COPD Patients : lessons from the Delta Variant / Lörinc Polivka, Istvan Valyi-Nagy, Zoltan Szekanecz, Krisztina Bogos, Hajnalka Vago, Anita Kamondi, Ferenc Fekete, Janos Szlavik, György Surjan, Orsolya Surjan, Peter Nagy, Zsuzsa Schaff, Zoltan Kiss, Cecilia Müller, Miklos Kasler, Veronika Müller
Dátum:	2023
ISSN:	2076-393X
Megjegyzések:	Although the COVID-19 pandemic is profoundly changing, data on the effect of vaccination and duration of protection against infection and severe disease can still be advantageous, especially for patients with COPD, who are more vulnerable to respiratory infections. The Hungarian COVID-19 registry was retrospectively investigated for risk of infection and hospitalization by time since the last vaccination, and vaccine effectiveness (VE) was calculated in adults with COPD diagnosis and an exact-matched control group during the Delta variant of concern (VOC) wave in Hungary (September-December 2021). For the matching, sex, age, major co-morbidities, vaccination status, and prior infection data were obtained on 23 August 2021. The study population included 373,962 cases divided into COPD patients (age: 66.67 +/- 12.66) and a 1:1 matched group (age: 66.73 +/- 12.67). In both groups, the female/male ratio was 52.2:47.7, respectively. Among the unvaccinated, there was no difference between groups in risk for infection or hospitalization. Regarding vaccinated cases, in the COPD group, a slightly faster decline in effectiveness was noted for hospitalization prevention, although in both groups, the vaccine lost its significant effect between 215 and 240 days after the last dose of vaccination. Based on a time-stratified multivariate Cox analysis of the vaccinated cases, the hazard was constantly higher in the COPD group, with an HR of 1.09 (95%: 1.05-1.14) for infection and 1.87 (95% CI: 1.59-2.19) for hospitalization. In our study, COPD patients displayed lower vaccine effectiveness against SARS-CoV-2 infection and hospitalization but a similar waning trajectory, as vaccines lost their preventive effect after 215 days. These data emphasize revaccination measures in the COPD patient population.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 COPD vaccine effectiveness VE waning
Megjelenés:	Vaccines. - 11 : 12 (2023), p. 1-12. -
További szerzők:	Vályi-Nagy István Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Bogos Krisztina Vágó Hajnalka (1972-) (orvos) Kamondi Anita Fekete Ferenc Szlávik János Surján György Surján Orsolya Nagy Péter Schaff Zsuzsa Kiss Zoltán Müller Cecília Kásler Miklós Müller Veronika
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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