CCL

Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM007057
Első szerző:Faragó Bernadett
Cím:Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis / Farago, B., Magyari, L., Safrany, E., Csongei, V., Jaromi, L., Horvatovich, K., Sipeky, C., Maasz, A., Radics, J., Gyetvai, A., Szekanecz, Z., Czirjak, L., Melegh, B.
Dátum:2008
ISSN:1468-2060 (Electronic)
Megjegyzések:Recently, an association was found between Crohn's disease and the interleukin-23 receptor (IL-23R) gene. Since the IL-23/IL-17 pathway is known to associate with other autoimmune diseases, including rheumatoid arthritis (RA) and systemic sclerosis (SSc), we hypothesised that IL-23R could be a shared susceptibility gene. METHODS: Groups of patients with rheumatoid arthritis (n = 412), systemic sclerosis (n = 224), Crohn's disease (n = 190) and healthy controls (n = 220) were genotyped for rs10889677 (exon-3'UTR C2370A), rs2201841, and rs1884444 variants; the first two have been shown to confer risk for Crohn's disease. RESULTS: We observed an increased prevalence of the homozygous rs10889677 AA and homozygous rs2201841 CC genotypes both in the Crohn's disease and in the RA groups as compared to the controls (12.1%, 11.9% vs 5.91%, p<0.05; and 13.2%, 13.1% vs 5.91%, p<0.05), but not in the SSc patients. Logistic regression analysis revealed that bearing these alleles represent risk for the development of rheumatoid arthritis (chi(2) = 5.58, p = 0.018, OR = 2.15, 95% CI 1.14-4.06 for rs10889677; and chi(2) = 7.45, p = 0.006, OR = 2.40, 95% CI 1.28-4.51 for rs2201841). The rs1884444 allele, which has been previously reported as neutral for development of Crohn's disease, was also found neutral for all studied groups in the present study. CONCLUSIONS: The data reported here provide direct evidence that some allelic variants or haplogroups of IL-23R represent independent risk factors for rheumatoid arthritis as well as Crohn's disease, but not for scleroderma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Arthritis, Rheumatoid
Autoantibodies
Crohn Disease
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Odds Ratio
Receptors, Interleukin
Scleroderma, Systemic
Megjelenés:Annals of the Rheumatic Diseases. - 67 : 2 (2008), p. 248-250. -
További szerzők:Magyari Lili Sáfrány Enikő Csöngei Veronika Járomi Luca Horvatovich Katalin Sipeky Csilla Maász Anita Radics J. Gyetvai Ágnes Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Czirják László Melegh Béla
Internet cím:elektronikus változat
elektronikus változat
Borító:
Rekordok letöltése1