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001-es BibID:BIBFORM007064
Első szerző:Halloran, Margaret M.
Cím:The role of an epithelial neutrophil-activating peptide-78-like protein in rat adjuvant-induced arthritis / Margaret M. Halloran, James M. Woods, Robert M. Strieter, Zoltan Szekanecz, Michael V. Volin, Shigeru Hosaka, G. Kenneth Haines III, Steven L. Kunkel, Marie D. Burdick, Alfred Walz, Alisa E. Koch
Dátum:1999
ISSN:0022-1767 (Print)
Megjegyzések:The chemokine, epithelial neutrophil-activating peptide-78 (ENA-78), is a potent neutrophil chemotaxin whose expression is increased in inflamed synovial tissue and fluid in human rheumatoid arthritis compared with osteoarthritis. Since ENA-78 has been implicated in the pathogenesis of RA, we examined the expression of an ENA-78-like protein during the development of rat adjuvant-induced arthritis (AIA). Using an ELISA assay, we found increased levels of antigenic ENA-78-like protein in the sera of AIA animals compared with control normal animals by day 7 postadjuvant injection. ENA-78-like protein levels continued to increase as AIA developed. ENA-78-like protein levels in joint homogenates were increased in AIA animals later in the development of the disease, by day 18 during maximal arthritis, compared with control animals. Expression of ENA-78-like protein in both the AIA serum and joint correlated with the progression of inflammation of the joints. Anti-human ENA-78 administered before disease onset modified the severity of AIA, while administration of anti-ENA-78 after clinical onset of AIA did not modify the disease. These data support a role for an ENA-78-like protein as an important chemokine in the progression and maintenance of AIA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Arthritis, Experimental
Cell Movement
Chemokine CXCL5
Chemokines, CXC
Epithelial Cells
Female
Immune Sera
Injections, Intraperitoneal
Interleukin-8
derivatives
Neutrophil Activation
Neutrophils
Peritoneum
Rats
Rats, Inbred Lew
Synovial Fluid
Tarsus, Animal
Time Factors
Megjelenés:The Journal of Immunology 162 : 12 (1999), p. 7492-7500. -
További szerzők:Woods, James M. Strieter, Robert M. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Volin, Michael V. Hosaka, Shigeru Haines, Kenneth G. III. Kunkel, Steven L. Burdick, Marie D. Walz, Alfred Koch, Alisa E.
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM007072
Első szerző:Koch, Alisa E.
Cím:In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis : their role in early and late disease / Koch, A. E., Kronfeld-Harrington, L. B., Szekanecz, Z., Cho, M. M., Haines, G. K., Harlow, L. A., Strieter, R. M., Kunkel, S. L., Massa, M. C., Barr, W. G., Jimenez, S. A.
Dátum:1993
ISSN:1015-2008 (Print)
Megjegyzések:Cytokines and cellular adhesion molecules (CAMs) may play a role in the inflammatory and fibrotic processes underlying systemic sclerosis (SSc). We compared the immunohistological distribution of cytokines and CAMs in skin biopsies from 12 SSc patients and 14 normal (NL) individuals. Among CAMs, vascular cell adhesion molecule-1 (VCAM-1), which mediates leukocyte-endothelial adhesion, showed increased expression on SSc versus NL endothelium and stratum granulosum. P-selectin was up-regulated in SSc versus NL stratum granulosum. The CD44 lymphocyte homing receptor showed the most striking differences between SSc and NL: its expression was increased in SSc stratum granulosum, stratum spinosum, on lymphocytes, and macrophages. Regarding cytokines, interleukin-6 (IL-6) expression was increased on SSc versus NL endothelium and fibroblasts. Tumor necrosis factor-alpha (TNF-alpha) reactivity was more prevalent in SSc than NL stratum granulosum, whereas IL-8 expression was higher on SSc compared to NL endothelium. Some CAMs, such as VCAM-1 and P-selectin, and cytokines, namely TNF-alpha and IL-8, were more commonly found in skin biopsies taken from early (< or = 1 year's duration) SSc, while others, such as IL-6, showed up-regulation in the late stage of the disease. The results suggest that certain CAMs and cytokines may play a differential role in both the early, inflammatory, and the late, fibrotic stage of SSc.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adult
Aged
Antigens, CD44
Biopsy
Carrier Proteins
Cell Adhesion
Cell Adhesion Molecules
Cytokines
Endothelium
Female
Fibroblasts
Humans
Immunohistochemistry
Interleukin-6
Interleukin-8
Male
Middle Aged
P-Selectin
Platelet Membrane Glycoproteins
Receptors, Cell Surface
Receptors, Lymphocyte Homing
Scleroderma, Systemic
Skin
Tumor Necrosis Factor-alpha
Vascular Cell Adhesion Molecule-1
Megjelenés:Pathobiology. - 61 : 5-6 (1993), p. 239-246. -
További szerzők:Kronfeld-Harrington, Lisa B. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Cho, Michael M. Haines, G. Kenneth Harlow, Lisa A. Strieter, Robert M. Kunkel, Steven L. Massa, Mary C. Barr, Walter G. Jimenez, Sergio A.
Internet cím:elektronikus változat
Borító:

3.

001-es BibID:BIBFORM007131
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Chemokines in rheumatoid arthritis / Szekanecz, Z., Strieter, R. M., Kunkel, S. L., Koch, A. E.
Dátum:1998
ISSN:0344-4325 (Print)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Anti-Inflammatory Agents
Antibodies
Antibody Specificity
Arthritis, Rheumatoid
Autoantibodies
Blood Coagulation Factors
Chemokine CXCL5
Chemokines
Chemokines, CC
Chemokines, CXC
Chemotaxis, Leukocyte
Humans
Interleukin-8
Peptides
Receptors, Chemokine
Synovial Fluid
Synovitis
Megjelenés:Springer Seminars in Immunopathology. - 20 : 1-2 (1998), p. 115-132. -
További szerzők:Strieter, Robert M. Kunkel, Steven L. Koch, Alisa E.
Internet cím:elektronikus változat
Borító:

4.

001-es BibID:BIBFORM007125
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Cytokines in rheumatoid arthritis : potential targets for pharmacological intervention / Szekanecz, Z., Koch, A. E., Kunkel, S. L., Strieter, R. M.
Dátum:1998
ISSN:1170-229X (Print)
Megjegyzések:The ingress of inflammatory leucocytes into the synovium is a crucial step in the pathogenesis of rheumatoid arthritis (RA). Cytokines are mediators involved in the inflammatory events, adhesive mechanisms, angiogenesis and osteopenia associated with RA. Pro- and anti-inflammatory cytokines, growth factors and chemokines all have an important role in these processes. Because the efficacy of currently used antirheumatic therapy is often limited, there is a need for more specific intervention strategies. Anticytokine therapy may include the use of monoclonal antibodies, antagonistic cytokines, soluble cytokine receptors, cytokine receptor antagonists, somatic gene transfer or other approaches. Hopefully, the study of cytokines and their interactions will lead to the development of new immunomodulatory strategies that will benefit patients with RA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Arthritis, Rheumatoid
Cytokines
Humans
Megjelenés:Drugs and Aging. - 12 : 5 (1998), p. 377-390. -
További szerzők:Koch, Alisa E. Kunkel, Steven L. Strieter, Robert M.
Internet cím:elektronikus változat
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5.

001-es BibID:BIBFORM007107
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritis / Szekanecz, Z., Halloran, M. M., Volin, M. V., Woods, J. M., Strieter, R. M., Kenneth Haines, G. 3rd, Kunkel, S. L., Burdick, M. D., Koch, A. E.
Dátum:2000
ISSN:0004-3591 (Print)
Megjegyzések:To examine cytokine and chemokine production during the evolution of rat adjuvant-induced arthritis (AIA), a model of rheumatoid arthritis. METHODS: Clinical and laboratory assessment of the course of AIA was performed over a 47-day period. Levels of the cytokines tumor necrosis factor a (TNFalpha), interleukin-1beta (IL-1beta), and IL-6, as well as levels of the chemokines macrophage inflammatory protein 1alpha (MIP-1alpha) and JE, the murine homolog of monocyte chemoattractant protein 1, were determined by enzyme-linked immunosorbent assay in the sera and joints of AIA and control rats. Synovia from AIA rats were (immuno)histochemically analyzed. Results of cytokine and chemokine measurements were correlated with clinical and laboratory markers of inflammation and histology. RESULTS: Early (before day 14 post adjuvant injection) and later phases of AIA could be distinguished. Cytokine and chemokine production was increased in AIA versus control rats. The production of TNFalpha, IL-1beta, MIP-1alpha, and, as determined earlier, epithelial neutrophil-activating peptide 78-like protein was abundant prior to and during the course of AIA, while that of IL-6 and JE was elevated in the late phase of AIA. Cytokine and chemokine levels were correlated with the clinical symptoms of arthritis and blood neutrophil counts. Joint levels of IL-1beta showed correlation with synovial lining proliferation and neutrophil ingress into AIA synovium. CONCLUSION: Cytokines and chemokines are involved in the clinical, laboratory, and histologic changes underlying AIA. The production of these mediators may be temporally and spatially regulated. These findings may be important for the optimal timing of cytokine and chemokine targeting.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Arthritis, Experimental
Chemokines
Cytokines
Enzyme-Linked Immunosorbent Assay
Female
Inflammation Mediators
Joints
Kinetics
Rats
Rats, Inbred Lew
Reference Values
Synovitis
Time Factors
Megjelenés:Arthritis and Rheumatism. - 43 : 6 (2000), p. 1266-1277. -
További szerzők:Halloran, Margaret M. Volin, Michael V. Woods, James M. Strieter, Robert M. Haines, Kenneth G. III. Kunkel, Steven L. Burdick, Marie D. Koch, Alisa E.
Internet cím:elektronikus változat
elektronikus változat
Szerző által megadott URL
DOI
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