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1.

001-es BibID:BIBFORM007072
Első szerző:Koch, Alisa E.
Cím:In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis : their role in early and late disease / Koch, A. E., Kronfeld-Harrington, L. B., Szekanecz, Z., Cho, M. M., Haines, G. K., Harlow, L. A., Strieter, R. M., Kunkel, S. L., Massa, M. C., Barr, W. G., Jimenez, S. A.
Dátum:1993
ISSN:1015-2008 (Print)
Megjegyzések:Cytokines and cellular adhesion molecules (CAMs) may play a role in the inflammatory and fibrotic processes underlying systemic sclerosis (SSc). We compared the immunohistological distribution of cytokines and CAMs in skin biopsies from 12 SSc patients and 14 normal (NL) individuals. Among CAMs, vascular cell adhesion molecule-1 (VCAM-1), which mediates leukocyte-endothelial adhesion, showed increased expression on SSc versus NL endothelium and stratum granulosum. P-selectin was up-regulated in SSc versus NL stratum granulosum. The CD44 lymphocyte homing receptor showed the most striking differences between SSc and NL: its expression was increased in SSc stratum granulosum, stratum spinosum, on lymphocytes, and macrophages. Regarding cytokines, interleukin-6 (IL-6) expression was increased on SSc versus NL endothelium and fibroblasts. Tumor necrosis factor-alpha (TNF-alpha) reactivity was more prevalent in SSc than NL stratum granulosum, whereas IL-8 expression was higher on SSc compared to NL endothelium. Some CAMs, such as VCAM-1 and P-selectin, and cytokines, namely TNF-alpha and IL-8, were more commonly found in skin biopsies taken from early (< or = 1 year's duration) SSc, while others, such as IL-6, showed up-regulation in the late stage of the disease. The results suggest that certain CAMs and cytokines may play a differential role in both the early, inflammatory, and the late, fibrotic stage of SSc.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adult
Aged
Antigens, CD44
Biopsy
Carrier Proteins
Cell Adhesion
Cell Adhesion Molecules
Cytokines
Endothelium
Female
Fibroblasts
Humans
Immunohistochemistry
Interleukin-6
Interleukin-8
Male
Middle Aged
P-Selectin
Platelet Membrane Glycoproteins
Receptors, Cell Surface
Receptors, Lymphocyte Homing
Scleroderma, Systemic
Skin
Tumor Necrosis Factor-alpha
Vascular Cell Adhesion Molecule-1
Megjelenés:Pathobiology. - 61 : 5-6 (1993), p. 239-246. -
További szerzők:Kronfeld-Harrington, Lisa B. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Cho, Michael M. Haines, G. Kenneth Harlow, Lisa A. Strieter, Robert M. Kunkel, Steven L. Massa, Mary C. Barr, Walter G. Jimenez, Sergio A.
Internet cím:elektronikus változat
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2.

001-es BibID:BIBFORM046369
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Differential distribution of intercellular adhesion molecules (ICAM-1, ICAM-2, and ICAM-3) and the MS-1 antigen in normal and diseased human synovia : their possible pathogenetic and clinical significance in rheumatoid arthritis / Szekanecz Z., Haines G. K., Lin T. R., Harlow L. A., Goerdt S., Rayan G., Koch A. E.
Dátum:1994
ISSN:0004-3591
Megjegyzések:Cellular adhesion and differentiation molecules (CAMs) may play a role in the recruitment and retention of inflammatory cells into rheumatoid arthritis synovial tissue (RA ST). In order to determine if certain CAMs are up-regulated in RA ST compared with normal ST, we studied the distribution of intercellular adhesion molecules (ICAMs) 1, 2, and 3 in ST. We also studied the MS-1 antigen since it is preferentially expressed on discontinuous endothelia, such as those found in RA ST; MS-1 is also expressed differentially upon cytokine activation of cells in vitro or in pathologic conditions in situ. Thus, we postulated a possible similarity between MS-1 and ICAM-1 expression in inflamed ST. METHODS. Immunohistochemical analysis was used to determine the distribution of ICAMs and MS-1 in ST from 10 patients with RA, 10 with osteoarthritis (OA), and 4 normal individuals. RESULTS. ICAM-1 expression was found on significantly more RA ST endothelial cells compared with normal cells, as well as on RA ST macrophages and lining cells. ICAM-2, also found on endothelial cells, showed no differential staining pattern. ICAM-3 was present on RA ST macrophages and lining cells as well as on some RA and OA endothelial cells. The MS-1 antigen was present on most RA and OA ST endothelia, lining cells, and macrophages. ICAM-1 expression and MS-1 expression in the lining layer were positively correlated in both RA and OA. CONCLUSION. ICAM-1, while found mainly on endothelial cells, is up-regulated on RA ST macrophages and lining cells, suggesting a role for these cells in the infiltration and tissue damage seen in the RA ST. ICAM-3, which is present mainly on normal resting leukocytes but not on normal endothelium, is expressed by some diseased ST leukocytes and endothelial cells. MS-1 is also found on the RA ST specialized, fenestrated endothelium, on macrophages, and in the lining layer. These results suggest that the differential expression of ICAMs and MS-1 in RA ST compared with normal ST might play a special role in the pathogenesis of RA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Arthritis and Rheumatism. - 37 : 2 (1994), p. 221-231. -
További szerzők:Haines, G. Kenneth Lin, Theodore R. Harlow, Lisa A. Goerdt, Sergij Rayan, Ghazi Koch, Alisa E.
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM007104
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis : possible interactions in the pathogenesis of the disease / Szekanecz, Z., Haines, G. K., Harlow, L. A., Shah, M. R., Fong, T. W., Fu, R., Lin, S. J., Rayan, G., Koch, A. E.
Dátum:1995
ISSN:0090-1229 (Print)
Megjegyzések:The ingress of inflammatory cells into the rheumatoid (RA) synovial tissue (ST) plays a role in the pathogenesis of this disease. Transforming growth factor beta (TGF-beta) may play a role in this process. We have investigated the distribution of endoglin, a newly described receptor for TGF-beta 1 and -beta 3, in RA compared to osteoarthritis (OA) or normal ST. Immunohistochemical analysis was carried out using an anti-TGF-beta 1 monoclonal antibody (mAb) as well as 10 mAbs raised against various epitopes of endoglin. This study was performed on ST from 10 patients with RA, 10 with OA, and 4 normal individuals. TGF-beta 1 expression was significantly up-regulated on RA compared to OA and normal ST lining cells, interstitial macrophages, and endothelial cells (P < 0.05). All anti-endoglin mAbs uniformly reacted with endothelial cells in RA, OA, and normal STs. However, 3 out of 10 anti-endoglin mAbs reacted with significantly more RA versus normal ST lining cells (P < 0.05), as well as RA compared to OA and normal macrophages (P < 0.05). There was a positive correlation between TGF-beta 1 and endoglin reactivity on the synovial lining layer and subsynovial macrophages (P < 0.05). These results indicate that TGF-beta 1 and certain epitopes of endoglin, a TGF-beta 1 and -beta 3 receptor, are up-regulated on myeloid elements in RA compared to normal ST. Endoglin is also present on ST endothelia, and its expression may also be increased on OA compared to normal ST lining cells. These findings implicate endoglin in the pathogenesis of RA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antibodies, Monoclonal
Antigens, CD
Arthritis, Rheumatoid
Humans
Membrane Glycoproteins
Osteoarthritis
Receptors, Cell Surface
Synovial Membrane
Transforming Growth Factor beta
Vascular Cell Adhesion Molecule-1
Megjelenés:Clinical Immunology and Immunopathology. - 76 : 2 (1995), p. 187-194. -
További szerzők:Haines, G. Kenneth Harlow, Lisa A. Shah, M. R. Fong, T. W. Fu, Rao Lin, S. J. Rayan, Ghazi Koch, Alisa E.
Internet cím:elektronikus változat
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM007103
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Increased synovial expression of the adhesion molecules CD66a, CD66b, and CD31 in rheumatoid and osteoarthritis / Szekanecz, Z., Haines, G. K., Harlow, L. A., Shah, M. R., Fong, T. W., Fu, R., Lin, S. J., Koch, A. E.
Dátum:1995
ISSN:0090-1229 (Print)
Megjegyzések:Leukocyte-endothelial interaction mediated by adhesion molecules may play a role in the ingress of inflammatory cells into the rheumatoid (RA) synovial tissue (ST). A number of these molecules have been shown to be up-regulated in the inflamed compared to normal ST. We studied the distribution of two members of the CD66 carcinoembryonic antigen adhesion molecule family, as well as that of CD31, an antigen structurally related to CD66, on various cell types in the RA compared to osteoarthritic (OA) and normal ST. Immunoperoxidase histochemistry was carried out using monoclonal antibodies to CD66a, CD66b, and CD31. This study was performed on ST from 10 patients with RA, 10 with OA, and 4 normal individuals. CD66a, and CD66b were expressed on RA and OA ST myeloid cells but not on normal ST lining cells and interstitial macrophages, suggesting that these antigens may be specific markers of diseased compared to normal ST macrophages (P < 0.05). CD31 was present on more RA and OA than on normal ST macrophages. Also, CD31 was present on most RA, OA, and normal ST endothelial cells. Our results indicate that the expression of CD66a, CD66b, and CD31, members of the immunoglobulin superfamily of adhesion receptors, is up-regulated on cells of myeloid origin in the inflamed compared to normal ST. These results suggest that the CD66 antigens and CD31 may be involved in the adhesive events in the inflamed synovium.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antigens, CD
Antigens, CD31
Antigens, Differentiation
Antigens, Differentiation, Myelomonocytic
Arthritis, Rheumatoid
Cell Adhesion Molecules
Humans
Osteoarthritis
Synovial Membrane
Megjelenés:Clinical Immunology and Immunopathology. - 76 : 2 (1995), p. 180-186. -
További szerzők:Haines, G. Kenneth Harlow, Lisa A. Shah, M. R. Fong, T. W. Fu, Rao Lin, S. J. Koch, Alisa E.
Internet cím:elektronikus változat
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM007127
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Interleukin-8 and tumor necrosis factor-alpha are involved in human aortic endothelial cell migration : the possible role of these cytokines in human aortic aneurysmal blood vessel growth / Szekanecz, Z., Shah, M. R., Harlow, L. A., Pearce, W. H., Koch, A. E.
Dátum:1994
ISSN:1015-2008 (Print)
Megjegyzések:Angiogenesis, the growth and proliferation of blood vessels, may be important in the pathogenesis of atherosclerosis and thus in human atherosclerotic abdominal aortic aneurysms (AAAs). Endothelial migration or chemotaxis is a vital component of the angiogenic response. Here, human aortic endothelial cells (hAECs) were used to investigate the effect of AAA tissue supernatants on hAEC chemotaxis. AAA tissue conditioned media were found to be chemotactic for hAECs. We have previously shown that the angiogenic cytokines interleukin (IL)-8, and tumor necrosis factor (TNF)-alpha are present in AAAs and normal aortic explant conditioned media. Currently, we have found that basic fibroblast growth factor (bFGF) and platelet-derived growth factor can also be detected in these supernatants. In order to identify whether some of these soluble mediators contributed to the chemotactic activity of these supernatants, conditioned media were preincubated with either neutralizing anti-IL-8, anti-TNF-alpha, anti-bFGF antibodies or control serum. Anti-IL-8 and anti-TNF-alpha significantly inhibited AAA tissue supernatant-induced hAEC chemotaxis (p < 0.05), while anti-bFGF did not (p not significant). These results indicate that IL-8 and TNF-alpha may be important in chemotactic activity for hAECs in vitro and possibly in AAA neovascularization. The abrogation of angiogenesis using neutralizing antibodies may be a future goal in the therapy of certain disease states such as AAA where angiogenesis plays an important role.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antibodies, Monoclonal
Aortic Aneurysm, Abdominal
Cell Movement
Cells, Cultured
Chemotaxis
Culture Media, Conditioned
Endothelium, Vascular
Enzyme-Linked Immunosorbent Assay
Fibroblast Growth Factor 2
Humans
Interleukin-8
Platelet-Derived Growth Factor
Tumor Necrosis Factor-alpha
Megjelenés:Pathobiology. - 62 : 3 (1994), p. 134-139. -
További szerzők:Shah, M. R. Harlow, Lisa A. Pearce, W. H. Koch, Alisa E.
Internet cím:elektronikus változat
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