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1.

001-es BibID:BIBFORM034670
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Mediators of angiogenesis : the role of cellular adhesion molecules / Szekanecz Zoltán, Halloran, M. M., Haskell, C. J., Shah, M. R., Polverini, P. J., Koch, Alicia E.
Dátum:1999
Megjegyzések:Angiogenesis, the production of new blood vessels, plays an important role in a number of physiological and pathological processes, such as development, tissue repair, inflammation, atherosclerosis and tumor progression. A number of mediators including cytokines, growth factors and others, have been implicated in angiogenesis. During tissue neovascularization, endothelial cells(EC) adhere to extracellular matrix(ECM) components and other ECs, which is an essential process in angiogenesis. Thus, in addition to soluble mediators mentioned above, ECM macromolecules and cellular adhesion molecules(CAMs) may also act as angiogenic factors. Among CAMs, E-selectin, vascular cell adhesion molecule(VCAM)-1, CD31, and some integrins may facilitate capillary formation both in vivo and in vitro. CAMs, as well as other angiogenic mediators may play a role in the pathogenesis of "angiogenic diseases". Targeting of any of these factors may have potential therapeutic relevance in such disorders. (author abst.)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Angiogenesis
Cellular Adhesion Molecules
külföldön készült közlemény
Megjelenés:Trends in Glycoscience and Glycotechnology. - 11 : 58 (1999), p. 73-93. -
További szerzők:Halloran, Margaret M. Haskell, C. J. Shah, M. R. Polverini, P. J. Koch, Alisa E.
Borító:

2.

001-es BibID:BIBFORM007104
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Increased synovial expression of transforming growth factor (TGF)-beta receptor endoglin and TGF-beta 1 in rheumatoid arthritis : possible interactions in the pathogenesis of the disease / Szekanecz, Z., Haines, G. K., Harlow, L. A., Shah, M. R., Fong, T. W., Fu, R., Lin, S. J., Rayan, G., Koch, A. E.
Dátum:1995
ISSN:0090-1229 (Print)
Megjegyzések:The ingress of inflammatory cells into the rheumatoid (RA) synovial tissue (ST) plays a role in the pathogenesis of this disease. Transforming growth factor beta (TGF-beta) may play a role in this process. We have investigated the distribution of endoglin, a newly described receptor for TGF-beta 1 and -beta 3, in RA compared to osteoarthritis (OA) or normal ST. Immunohistochemical analysis was carried out using an anti-TGF-beta 1 monoclonal antibody (mAb) as well as 10 mAbs raised against various epitopes of endoglin. This study was performed on ST from 10 patients with RA, 10 with OA, and 4 normal individuals. TGF-beta 1 expression was significantly up-regulated on RA compared to OA and normal ST lining cells, interstitial macrophages, and endothelial cells (P < 0.05). All anti-endoglin mAbs uniformly reacted with endothelial cells in RA, OA, and normal STs. However, 3 out of 10 anti-endoglin mAbs reacted with significantly more RA versus normal ST lining cells (P < 0.05), as well as RA compared to OA and normal macrophages (P < 0.05). There was a positive correlation between TGF-beta 1 and endoglin reactivity on the synovial lining layer and subsynovial macrophages (P < 0.05). These results indicate that TGF-beta 1 and certain epitopes of endoglin, a TGF-beta 1 and -beta 3 receptor, are up-regulated on myeloid elements in RA compared to normal ST. Endoglin is also present on ST endothelia, and its expression may also be increased on OA compared to normal ST lining cells. These findings implicate endoglin in the pathogenesis of RA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antibodies, Monoclonal
Antigens, CD
Arthritis, Rheumatoid
Humans
Membrane Glycoproteins
Osteoarthritis
Receptors, Cell Surface
Synovial Membrane
Transforming Growth Factor beta
Vascular Cell Adhesion Molecule-1
Megjelenés:Clinical Immunology and Immunopathology. - 76 : 2 (1995), p. 187-194. -
További szerzők:Haines, G. Kenneth Harlow, Lisa A. Shah, M. R. Fong, T. W. Fu, Rao Lin, S. J. Rayan, Ghazi Koch, Alisa E.
Internet cím:elektronikus változat
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM007103
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Increased synovial expression of the adhesion molecules CD66a, CD66b, and CD31 in rheumatoid and osteoarthritis / Szekanecz, Z., Haines, G. K., Harlow, L. A., Shah, M. R., Fong, T. W., Fu, R., Lin, S. J., Koch, A. E.
Dátum:1995
ISSN:0090-1229 (Print)
Megjegyzések:Leukocyte-endothelial interaction mediated by adhesion molecules may play a role in the ingress of inflammatory cells into the rheumatoid (RA) synovial tissue (ST). A number of these molecules have been shown to be up-regulated in the inflamed compared to normal ST. We studied the distribution of two members of the CD66 carcinoembryonic antigen adhesion molecule family, as well as that of CD31, an antigen structurally related to CD66, on various cell types in the RA compared to osteoarthritic (OA) and normal ST. Immunoperoxidase histochemistry was carried out using monoclonal antibodies to CD66a, CD66b, and CD31. This study was performed on ST from 10 patients with RA, 10 with OA, and 4 normal individuals. CD66a, and CD66b were expressed on RA and OA ST myeloid cells but not on normal ST lining cells and interstitial macrophages, suggesting that these antigens may be specific markers of diseased compared to normal ST macrophages (P < 0.05). CD31 was present on more RA and OA than on normal ST macrophages. Also, CD31 was present on most RA, OA, and normal ST endothelial cells. Our results indicate that the expression of CD66a, CD66b, and CD31, members of the immunoglobulin superfamily of adhesion receptors, is up-regulated on cells of myeloid origin in the inflamed compared to normal ST. These results suggest that the CD66 antigens and CD31 may be involved in the adhesive events in the inflamed synovium.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antigens, CD
Antigens, CD31
Antigens, Differentiation
Antigens, Differentiation, Myelomonocytic
Arthritis, Rheumatoid
Cell Adhesion Molecules
Humans
Osteoarthritis
Synovial Membrane
Megjelenés:Clinical Immunology and Immunopathology. - 76 : 2 (1995), p. 180-186. -
További szerzők:Haines, G. Kenneth Harlow, Lisa A. Shah, M. R. Fong, T. W. Fu, Rao Lin, S. J. Koch, Alisa E.
Internet cím:elektronikus változat
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM007129
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4 : the possible role for IL-6 and interferon-gamma in vascular inflammation / Szekanecz, Z., Shah, M. R., Pearce, W. H., Koch, A. E.
Dátum:1994
ISSN:0065-4299 (Print)
Megjegyzések:Immunological mechanisms play an important role in the pathogenesis of atherosclerosis and atherosclerotic abdominal aortic aneurysms (AAA). Inflammatory leukocytes invade the vessel wall and produce cytokines which perpetuate the immune events underlying these diseases. Interleukin (IL)-1 beta, IL-8, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1, among others, may play a role in the generation by AAA. The aim of this study was to investigate the possible pathogenetic role of other proinflammatory cytokines, namely IL-2, IL-4, IL-6, and interferon (IFN)-gamma. Enzyme-linked immunosorbent assay of human explant culture supernatants revealed a significant increase in IFN-gamma production by AAA compared to occlusive (atherosclerotic) or normal (NL) aortic explants. IL-6 production was also increased in AAA compared to NL aortic explant supernatants. Neither AAA nor NL aortic tissues produced IL-2 or IL-4 in the same culture system. These results suggest that IL-6, a cytokine involved in T and B lymphocyte activation during inflammation, and IFN-gamma, which stimulates T and B lymphocytes, macrophages, endothelial cells and fibroblasts, may play a role in the pathogenesis of various vascular inflammatory diseases such as AAA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aorta, Abdominal
Aortic Aneurysm, Abdominal
Arteriosclerosis
Culture Media, Conditioned
Enzyme-Linked Immunosorbent Assay
Humans
Interferon-gamma
Interleukin-2
Interleukin-4
Interleukin-6
Vasculitis
Megjelenés:Agents and Actions. - 42 : 3-4 (1994), p. 159-162. -
További szerzők:Shah, M. R. Pearce, W. H. Koch, Alisa E.
Internet cím:elektronikus változat
Borító:

5.

001-es BibID:BIBFORM007128
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Intercellular adhesion molecule-1 (ICAM-1) expression and soluble ICAM-1 (sICAM-1) production by cytokine-activated human aortic endothelial cells : a possible role for ICAM-1 and sICAM-1 in atherosclerotic aortic aneurysms / Szekanecz, Z., Shah, M. R., Pearce, W. H., Koch, A. E.
Dátum:1994
ISSN:0009-9104 (Print)
Megjegyzések:The interactions of inflammatory cells, cytokines, and cell adhesion molecules (CAM) may be important in the pathogenesis of vascular diseases such as abdominal aortic aneurysms (AAA), in which inflammation plays a role. The aim of this study was to investigate the pathogenic role of ICAM-1, a molecule involved in leucocyte-endothelial interactions, in vascular inflammation. ELISA of human explant culture supernatants revealed a four-fold increase in sICAM-1 production by AAA (n = 9) versus normal (n = 8) aortic explants. Human aortic endothelial cell (hAEC) culture was used for further studies as an in vitro model for aortic inflammatory conditions. Tumour necrosis factor-alpha (TNF-alpha) or IL-1 beta treatment of hAEC resulted in an up to 1.8-fold significant increase in sICAM-1 production compared with resting cells. In addition, the expression of ICAM-1 on cytokine-stimulated versus resting hAEC was measured by radioimmunoassay. TNF-alpha significantly induced ICAM-1 expression on these cells. These results suggest that different forms of ICAM-1, present on or released by the activated aortic endothelium, may be involved in leucocyte adhesion to and migration into the vessel wall.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aorta, Abdominal
Aortic Aneurysm, Abdominal
Arteriosclerosis
Cells, Cultured
Culture Media, Conditioned
Cytokines
Endothelium, Vascular
Enzyme-Linked Immunosorbent Assay
HLA-DR Antigens
Humans
Intercellular Adhesion Molecule-1
Radioimmunoassay
Megjelenés:Clinical and Experimental Immunology. - 98 : 2 (1994), p. 337-343. -
További szerzők:Shah, M. R. Pearce, W. H. Koch, Alisa E.
Internet cím:elektronikus változat
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM007127
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Interleukin-8 and tumor necrosis factor-alpha are involved in human aortic endothelial cell migration : the possible role of these cytokines in human aortic aneurysmal blood vessel growth / Szekanecz, Z., Shah, M. R., Harlow, L. A., Pearce, W. H., Koch, A. E.
Dátum:1994
ISSN:1015-2008 (Print)
Megjegyzések:Angiogenesis, the growth and proliferation of blood vessels, may be important in the pathogenesis of atherosclerosis and thus in human atherosclerotic abdominal aortic aneurysms (AAAs). Endothelial migration or chemotaxis is a vital component of the angiogenic response. Here, human aortic endothelial cells (hAECs) were used to investigate the effect of AAA tissue supernatants on hAEC chemotaxis. AAA tissue conditioned media were found to be chemotactic for hAECs. We have previously shown that the angiogenic cytokines interleukin (IL)-8, and tumor necrosis factor (TNF)-alpha are present in AAAs and normal aortic explant conditioned media. Currently, we have found that basic fibroblast growth factor (bFGF) and platelet-derived growth factor can also be detected in these supernatants. In order to identify whether some of these soluble mediators contributed to the chemotactic activity of these supernatants, conditioned media were preincubated with either neutralizing anti-IL-8, anti-TNF-alpha, anti-bFGF antibodies or control serum. Anti-IL-8 and anti-TNF-alpha significantly inhibited AAA tissue supernatant-induced hAEC chemotaxis (p < 0.05), while anti-bFGF did not (p not significant). These results indicate that IL-8 and TNF-alpha may be important in chemotactic activity for hAECs in vitro and possibly in AAA neovascularization. The abrogation of angiogenesis using neutralizing antibodies may be a future goal in the therapy of certain disease states such as AAA where angiogenesis plays an important role.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antibodies, Monoclonal
Aortic Aneurysm, Abdominal
Cell Movement
Cells, Cultured
Chemotaxis
Culture Media, Conditioned
Endothelium, Vascular
Enzyme-Linked Immunosorbent Assay
Fibroblast Growth Factor 2
Humans
Interleukin-8
Platelet-Derived Growth Factor
Tumor Necrosis Factor-alpha
Megjelenés:Pathobiology. - 62 : 3 (1994), p. 134-139. -
További szerzők:Shah, M. R. Harlow, Lisa A. Pearce, W. H. Koch, Alisa E.
Internet cím:elektronikus változat
Borító:
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