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1.

001-es BibID:BIBFORM007129
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Human atherosclerotic abdominal aortic aneurysms produce interleukin (IL)-6 and interferon-gamma but not IL-2 and IL-4 : the possible role for IL-6 and interferon-gamma in vascular inflammation / Szekanecz, Z., Shah, M. R., Pearce, W. H., Koch, A. E.
Dátum:1994
ISSN:0065-4299 (Print)
Megjegyzések:Immunological mechanisms play an important role in the pathogenesis of atherosclerosis and atherosclerotic abdominal aortic aneurysms (AAA). Inflammatory leukocytes invade the vessel wall and produce cytokines which perpetuate the immune events underlying these diseases. Interleukin (IL)-1 beta, IL-8, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1, among others, may play a role in the generation by AAA. The aim of this study was to investigate the possible pathogenetic role of other proinflammatory cytokines, namely IL-2, IL-4, IL-6, and interferon (IFN)-gamma. Enzyme-linked immunosorbent assay of human explant culture supernatants revealed a significant increase in IFN-gamma production by AAA compared to occlusive (atherosclerotic) or normal (NL) aortic explants. IL-6 production was also increased in AAA compared to NL aortic explant supernatants. Neither AAA nor NL aortic tissues produced IL-2 or IL-4 in the same culture system. These results suggest that IL-6, a cytokine involved in T and B lymphocyte activation during inflammation, and IFN-gamma, which stimulates T and B lymphocytes, macrophages, endothelial cells and fibroblasts, may play a role in the pathogenesis of various vascular inflammatory diseases such as AAA.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aorta, Abdominal
Aortic Aneurysm, Abdominal
Arteriosclerosis
Culture Media, Conditioned
Enzyme-Linked Immunosorbent Assay
Humans
Interferon-gamma
Interleukin-2
Interleukin-4
Interleukin-6
Vasculitis
Megjelenés:Agents and Actions. - 42 : 3-4 (1994), p. 159-162. -
További szerzők:Shah, M. R. Pearce, W. H. Koch, Alisa E.
Internet cím:elektronikus változat
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2.

001-es BibID:BIBFORM007128
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Intercellular adhesion molecule-1 (ICAM-1) expression and soluble ICAM-1 (sICAM-1) production by cytokine-activated human aortic endothelial cells : a possible role for ICAM-1 and sICAM-1 in atherosclerotic aortic aneurysms / Szekanecz, Z., Shah, M. R., Pearce, W. H., Koch, A. E.
Dátum:1994
ISSN:0009-9104 (Print)
Megjegyzések:The interactions of inflammatory cells, cytokines, and cell adhesion molecules (CAM) may be important in the pathogenesis of vascular diseases such as abdominal aortic aneurysms (AAA), in which inflammation plays a role. The aim of this study was to investigate the pathogenic role of ICAM-1, a molecule involved in leucocyte-endothelial interactions, in vascular inflammation. ELISA of human explant culture supernatants revealed a four-fold increase in sICAM-1 production by AAA (n = 9) versus normal (n = 8) aortic explants. Human aortic endothelial cell (hAEC) culture was used for further studies as an in vitro model for aortic inflammatory conditions. Tumour necrosis factor-alpha (TNF-alpha) or IL-1 beta treatment of hAEC resulted in an up to 1.8-fold significant increase in sICAM-1 production compared with resting cells. In addition, the expression of ICAM-1 on cytokine-stimulated versus resting hAEC was measured by radioimmunoassay. TNF-alpha significantly induced ICAM-1 expression on these cells. These results suggest that different forms of ICAM-1, present on or released by the activated aortic endothelium, may be involved in leucocyte adhesion to and migration into the vessel wall.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Aorta, Abdominal
Aortic Aneurysm, Abdominal
Arteriosclerosis
Cells, Cultured
Culture Media, Conditioned
Cytokines
Endothelium, Vascular
Enzyme-Linked Immunosorbent Assay
HLA-DR Antigens
Humans
Intercellular Adhesion Molecule-1
Radioimmunoassay
Megjelenés:Clinical and Experimental Immunology. - 98 : 2 (1994), p. 337-343. -
További szerzők:Shah, M. R. Pearce, W. H. Koch, Alisa E.
Internet cím:elektronikus változat
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3.

001-es BibID:BIBFORM007127
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Interleukin-8 and tumor necrosis factor-alpha are involved in human aortic endothelial cell migration : the possible role of these cytokines in human aortic aneurysmal blood vessel growth / Szekanecz, Z., Shah, M. R., Harlow, L. A., Pearce, W. H., Koch, A. E.
Dátum:1994
ISSN:1015-2008 (Print)
Megjegyzések:Angiogenesis, the growth and proliferation of blood vessels, may be important in the pathogenesis of atherosclerosis and thus in human atherosclerotic abdominal aortic aneurysms (AAAs). Endothelial migration or chemotaxis is a vital component of the angiogenic response. Here, human aortic endothelial cells (hAECs) were used to investigate the effect of AAA tissue supernatants on hAEC chemotaxis. AAA tissue conditioned media were found to be chemotactic for hAECs. We have previously shown that the angiogenic cytokines interleukin (IL)-8, and tumor necrosis factor (TNF)-alpha are present in AAAs and normal aortic explant conditioned media. Currently, we have found that basic fibroblast growth factor (bFGF) and platelet-derived growth factor can also be detected in these supernatants. In order to identify whether some of these soluble mediators contributed to the chemotactic activity of these supernatants, conditioned media were preincubated with either neutralizing anti-IL-8, anti-TNF-alpha, anti-bFGF antibodies or control serum. Anti-IL-8 and anti-TNF-alpha significantly inhibited AAA tissue supernatant-induced hAEC chemotaxis (p < 0.05), while anti-bFGF did not (p not significant). These results indicate that IL-8 and TNF-alpha may be important in chemotactic activity for hAECs in vitro and possibly in AAA neovascularization. The abrogation of angiogenesis using neutralizing antibodies may be a future goal in the therapy of certain disease states such as AAA where angiogenesis plays an important role.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Antibodies, Monoclonal
Aortic Aneurysm, Abdominal
Cell Movement
Cells, Cultured
Chemotaxis
Culture Media, Conditioned
Endothelium, Vascular
Enzyme-Linked Immunosorbent Assay
Fibroblast Growth Factor 2
Humans
Interleukin-8
Platelet-Derived Growth Factor
Tumor Necrosis Factor-alpha
Megjelenés:Pathobiology. - 62 : 3 (1994), p. 134-139. -
További szerzők:Shah, M. R. Harlow, Lisa A. Pearce, W. H. Koch, Alisa E.
Internet cím:elektronikus változat
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