Találati lista | Tudóstér

001-es BibID:	BIBFORM064520
Első szerző:	Ghassemi-Nejad, Sheida (fogorvos)
Cím:	Development of temporomandibular joint arthritis : the use of animal models / Sheida Ghassemi Nejad, Tamás Kobezda, Ildikó Tar, Zoltán Szekanecz
Dátum:	2017
ISSN:	1297-319X 1778-7254
Megjegyzések:	Osteoarthritis is the most common joint disease affecting roughly one sixth of the human population. It isalso the most common arthritis affecting the temporomandibular joint, often leading to severe pain andthe inability to masticate. Animal models are essential to investigate the disease in part because they lendthemselves to genetic manipulation and various treatments and also because of the lack of availabilityof human specimens from various stages of the disease. The wide range of osteoarthritis models aloneare a proof of its multifactorial origin. Manipulation of collagen, cytokine, matrix metalloproteinase andsmall leucine-rich repeat proteoglycan genes can all have an effect on the development and persistenceof arthritis. Surgical models also exist, highlighting the importance of normal anatomy and trauma. Herewe review the English literature of murine models of temporomandibular joint arthritis with specialattention to the genetic and molecular background of osteoarthritis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Arthritis Temporomandibular joint Animal models Murine model
Megjelenés:	Joint Bone Spine 84 : 2 (2017), p. 145-151. -
További szerzők:	Kobezda Tamás (1983-) (Ph.D hallgató) Tar Ildikó (1967-) (fogszakorvos) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM049171
Első szerző:	Kobezda Tamás (Ph.D hallgató)
Cím:	Of mice and men : how animal models advance our understanding of T-cell function in RA / Tamás Kobezda, Sheida Ghassemi-Nejad, Katalin Mikecz, Tibor T. Glant, Zoltán Szekanecz
Dátum:	2014
ISSN:	1759-4790 1759-4804
Megjegyzések:	The involvement of autoreactive T cells in the pathogenesis of rheumatoid arthritis (RA) as well as in autoimmune animal models of arthritis has been well established; however, unanswered questions, such as the role of joint-homing T cells, remain. Animal models of arthritis are superb experimental tools in demonstrating how T cells trigger joint inflammation, and thus can help to further our knowledge of disease mechanisms and potential therapies. In this Review, we discuss the similarities and differences in T-cell subsets and functions between RA and mouse arthritis models. For example, various T-cell subsets are involved in both human and mouse arthritis, but differences might exist in the cytokine regulation and plasticity of these cells. With regard to joint-homing T cells, an abundance of synovial T cells is present in humans compared with mice. On the other hand, local expansion of type 17 T-helper (TH17) cells is observed in some animal models, but not in RA. Finally, whereas T-cell depletion therapy essentially failed in RA, antibody targeting of T cells can work, at least preventatively, in most arthritis models. Clearly, additional human and animal studies are needed to fill the gap in our understanding of the specific contribution of T-cell subsets to arthritis in mice and men.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban T-cell responses T-cell clonal expansion
Megjelenés:	Nature Reviews Rheumatology. - 10 : 3 (2014), p. 160-170. -
További szerzők:	Ghassemi-Nejad, Sheida (1980-) (fogorvos) Mikecz Katalin Glant Tibor T. Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: