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001-es BibID:	BIBFORM015794
Első szerző:	Arnson, Yoav
Cím:	Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis a retrospective cohort study and review of the literature / Yoav Arnson, Howard Amital, Nancy Agmon-Levin, Danny Alon, María Sánchez-Castanón, Marcos López-Hoyos, Marco Matucci-Cerinic, Gabriella Szücs, Yinon Shapira, Zoltan Szekanecz, Yehuda Shoenfeld
Dátum:	2011
ISSN:	1568-9972
Megjegyzések:	Low vitamin D serum concentrations have been reported in several autoimmune conditions. The study's aim was to explore such a relationship in a large multinational population of patients with systemic sclerosis (SSc) and to pursue possible clinical and laboratory correlates with vitamin D concentrations. 327 sera samples of European patients with SSc and 141 samples of compatible healthy controls were studied for vitamin D concentrations using the commercial kit LIAISON 25-OH vitamin D assay (Diasorin). Additionally, clinical parameters including the Rodnan skin score, diffusing lung capacity for carbon monoxide (DLCO), systolic pulmonary artery pressure (sPAP), forced vital capacity (FVC), and nailfold video capillaroscopic, erythrocyte sedimentation rate (ESR), anti-nuclear antibodies (ANA and scl70), rheumatoid factor (RF) were investigated. Vitamin D serum concentration was 13.5+/-9.0ng/ml (mean+/-standard deviation) in patients with SSc compared to 21.6+/-9.7ng/ml in a control group (p<0.001). A negative correlation between patients' age and vitamin D concentration (r=-0.2, p<0.05, n=96) was observed. An inverse relationship was found between skin involvement and vitamin D serum concentrations; Patients with a Rodnan skin score of 10 or lower (n=11) had a mean vitamin D concentration of 17.7+/-10.4ng/ml compared to patients with a score above 10 (n=28) 8+/-10.1ng/ml (p=0.02, by the Mann-Whitney test). In conclusion, Patients with SSc have significantly lower serum vitamin D concentrations compared to healthy controls; moreover fibrosis of the cutaneous tissue is inversely related to the vitamin D concentration.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Autoimmunity Reviews. - 10 : 8 (2011), p. 490-494. -
További szerzők:	Amital, Howard Agmon-Levin, Nancy Alon, Danny Sánchez-Castanón, María Lopez-Hoyos, Marcos Matucci-Cerinic, Marco Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Shapira, Yinon Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Shoenfeld, Yehuda
Internet cím:	DOI elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM015795
Első szerző:	Avouac, Jérôme
Cím:	Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis : results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database / Avouac, J., Walker, U., Tyndall, A., Kahan, A., Matucci-Cerinic, M., Allanore, Y., EUSTAR
Dátum:	2010
ISSN:	0315-162X (Print)
Megjegyzések:	To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc). METHODS: This study was cross-sectional, based on data collected on patients included in the European League Against Rheumatism (EULAR) Scleroderma Trials and Research (EUSTAR) registry. We queried this database to extract data regarding global evaluation of patients with SSc and the presence of any clinical articular involvement: synovitis (tender and swollen joints), tendon friction rubs (rubbing sensation detected as the tendon was moved), and joint contracture (stiffness of the joints that decreased their range of motion). Overall joint involvement was defined by the occurrence of synovitis and/or joint contracture and/or tendon friction rubs. RESULTS: We recruited 7286 patients with SSc; their mean age was 56 +/- 14 years, disease duration 10 +/- 9 years, and 4210 (58%) had a limited cutaneous disease subset. Frequencies of synovitis, tendon friction rubs, and joint contractures were 16%, 11%, and 31%, respectively. Synovitis, tendon friction rubs, and joint contracture were more prevalent in patients with the diffuse cutaneous subset and were associated together and with severe vascular, muscular, renal, and interstitial lung involvement. Moreover, synovitis had the highest strength of association with elevated acute-phase reactants taken as the dependent variable. CONCLUSION: Our results highlight the striking level of articular involvement in SSc, as evaluated by systematic examination in a large cohort of patients with SSc. Our data also show that synovitis, joint contracture, and tendon friction rubs are associated with a more severe disease and with systemic inflammation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Aged Clinical Trials as Topic Cross-Sectional Studies Databases, Factual Female Humans Inflammation Joint Diseases Joints/pathology Male Middle Aged Range of Motion, Articular Scleroderma, Localized Scleroderma, Systemic Synovitis Tendons
Megjelenés:	The Journal of Rheumatology. - 37 : 7 (2010), p. 1488-1501. -
További szerzők:	Walker, Ulrich Tyndall, Alan Kahan, André Matucci-Cerinic, Marco Allanore, Yannick Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) EUSTAR
Internet cím:	DOI elektronikus változat Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM082169
035-os BibID:	(PMID)31733368 (cikkazonosító)102421
Első szerző:	Favalli, Ennio Giulio
Cím:	The Giants (biologicals) against the Pigmies (small molecules), pros and cons of two different approaches to the disease modifying treatment in rheumatoid arthritis / Ennio Giulio Favalli, Marco Matucci-Cerinic, Zoltan Szekanecz
Dátum:	2020
ISSN:	1568-9972
Megjegyzések:	Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that, if untreated, can lead to disability and reduce the life expectancy of affected patients. Over the last two decades the improvement of knowledge of the pathogenetic mechanisms leading to the development of the disease has profoundly changed the treatment strategies of RA through the development of biotechnological drugs (bDMARDs) directed towards specific proinflammatory targets involved in the RA network. To date, the therapeutic armamentarium for RA includes ten bDMARDs able to produce the depletion B-cells, the blockade of three different pro-inflammatory cytokines (tumour necrosis factor alpha, interleukin-6 and interleukin-1), or the inhibition of T-cell co-stimulation. The introduction of these new compounds has dramatically improved outcomes in the short and long term, although still a significant proportion of patients are unable to reach or maintain the treatment target over time. The identification of the fundamental role of Janus kinases in the process of transduction of the inflammatory signal within the immune cells has recently provided the opportunity to use the new pharmacological class of small molecules for the therapy of RA, further increasing the number of treatment options. In this review the PROS and CONS of these two drug classes will be discussed, trying to provide the evidence currently available to make the right choice based on the analysis of the efficacy and safety profile of the different drugs on the market and close to marketing.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Biologic agents Efficacy JAK inhibitors Personalised medicine Rheumatoid arthritis Safety profile
Megjelenés:	Autoimmunity Reviews. - 19 : 1 (2020), p. 1-8. -
További szerzők:	Matucci-Cerinic, Marco Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM033529
035-os BibID:	PMID:19147617
Első szerző:	Kowal-Bielecka, Otylia
Cím:	EULAR recommendations for the treatment of systemic sclerosis : a report from the EULAR Scleroderma Trials and Research group (EUSTAR) / O. Kowal-Bielecka, R. Landewé, J. Avouac, S. Chwiesko, I. Miniati, L. Czirjak, P. Clements, C. Denton, D. Farge, K. Fligelstone, I. Földvari, D. E. Furst, U. Müller-Ladner, J. Seibold, R. M. Silver, K. Takehara, B. Garay Toth, A. Tyndall, G. Valentini, F. van den Hoogen, F. Wigley, F. Zulian, Marco Matucci-Cerinic, EUSTAR co-authors
Dátum:	2009
ISSN:	0003-4967
Megjegyzések:	PURPOSE: The optimal treatment of systemic sclerosis (SSc) is a challenge because the pathogenesis of SSc is unclear and it is an uncommon and clinically heterogeneous disease affecting multiple organ systems. The aim of the European League Against Rheumatism (EULAR) Scleroderma Trials and Research group (EUSTAR) was to develop evidence-based, consensus-derived recommendations for the treatment of SSc. METHODS: To obtain and maintain a high level of intrinsic quality and comparability of this approach, EULAR standard operating procedures were followed. The task force comprised 18 SSc experts from Europe, the USA and Japan, two SSc patients and three fellows for literature research. The preliminary set of research questions concerning SSc treatment was provided by 74 EUSTAR centres. RESULTS: Based on discussion of the clinical research evidence from published literature, and combining this with current expert opinion and clinical experience, 14 recommendations for the treatment of SSc were formulated. The final set includes the following recommendations: three on SSc-related digital vasculopathy (Raynaud's phenomenon and ulcers); four on SSc-related pulmonary arterial hypertension; three on SSc-related gastrointestinal involvement; two on scleroderma renal crisis; one on SSc-related interstitial lung disease and one on skin involvement. Experts also formulated several questions for a future research agenda. CONCLUSIONS: Evidence-based, consensus-derived recommendations are useful for rheumatologists to help guide treatment for patients with SSc. These recommendations may also help to define directions for future clinical research in SSc.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Annals Of The Rheumatic Diseases. - 68 : 5 (2009), p. 620-628. -
További szerzők:	Landewé, Robert Avouac, Jérôme Chwiesko, S. Miniati, I. Czirják László Clements, Philip Denton, Christopher Farge, D. Fligelstone, Kim Földvári I. Furst, Daniel E. Müller-Ladner, Ulf Seibold, J. Silver, R. M. Takehara, Kazuhiro Garay Tóth B. Tyndall, Alan Valentini, Gabriele Hoogen, F. van den Wigley, Frederic Zulian, Francesco Matucci-Cerinic, Marco Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) EUSTAR
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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