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001-es BibID:	BIBFORM044035
Első szerző:	Szabó Melinda
Cím:	Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis / Szabo Melinda, Safrany Eniko, Pazar Borbala, Melegh Bela I., Kisfali Peter, Poor Gyula, Figler Maria, Szekanecz Zoltan, Czirjak Laszlo, Melegh Bela
Dátum:	2013
ISSN:	0301-4851
Megjegyzések:	Haplotype tagging SNPs of interleukin-23 receptor gene rs1004819, rs7517847, rs7530511, rs2201841, rs1343151 and rs10889677 were determined in 396 patients with rheumatoid arthritis, 190 patients with Crohn's disease, 206 patients with ankylosing spondylitis and 182 controls. Using regression analysis models the rs1004819, rs2201841, and rs10889677 SNPs were found to confer risk for Crohn's disease and ankylosing spondylitis, while rs1343151 had a protective effect in both of these diseases, and the rs2201841 and rs10889677 SNPs showed susceptibility nature for rheumatoid arthritis. Using these SNPs we could study the susceptibility haplotype profiles in these diseases with special attention to the rheumatoid arthritis, first in the literature. Seven different haplotypes could be differentiated. We found that the SNPs exert their susceptibility character in specific haplotype blocks: thus, for rheumatoid arthritis the rs1343151 SNP was risk factor only in a specific haplotype surrounding; this can explain the controversial results published so far about this variant. More importantly, we observed, that while a specific haplotype can confer risk for rheumatoid arthritis, the same haplotype tended to protect against the development of the other two diseases. The data presented here serve evidence for the need of haplotype analysis instead of just single standing SNP analysis when susceptibility to or protection against a certain disease are interpreted.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Interleukin-23 receptor gene Autoimmune disease SNP
Megjelenés:	Molecular Biology Reports. - 40 : 1 (2013), p. 359-363. -
További szerzők:	Sáfrány Enikő Pazár Borbála Melegh Béla I. Kisfali Péter Poór Gyula Figler Mária Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Czirják László Melegh Béla
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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