CCL

Összesen 2 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM056680
Első szerző:Pavelka, Karel
Cím:Etanercept in moderate rheumatoid arthritis : PRESERVE study results from central/eastern Europe, Latin America and Asia / Karel Pavelka, Ruben Burgos-Vargas, Pedro Miranda, Renato Guzman, Jeng-Hsien Yen, Mustafa Al Izzi, Zoltan Szekanecz, Boxiong Tang, Annette Szumski, Sameer Kotak, Eustratios Bananis, Andrew S. Koenig, Ehab Y. Mahgoub, Mahboob U. Rahman
Dátum:2014
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Köszvény
Megjelenés:International Journal of Clinical Rheumatology. - 9 (2014), p. 415-430. -
További szerzők:Burgos-Vargas, Ruben Miranda, Pedro Guzman, R. Yen, Jeng-Hsien Al Izzi, Mustafa Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Tang, Boxiong Szumski, Annette Kotak, Sameer Bananis, Eustratios Koenig, Andrew S. Mahgoub, Youseif E. Rahman, Mahboob U.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM051426
035-os BibID:PMID:23666316
Első szerző:Pavelka, Karel
Cím:Induction of response with etanercept-methotrexate therapy in patients with moderately active rheumatoid arthritis in Central and Eastern Europe in the PRESERVE study / Karel Pavelka, Zoltan Szekanecz, Nemanja Damjanov, Maria Majdan, Evgeny Nasonov, Vadim Mazurov, Tibor Fabo, Eustratios Bananis, Heather Jones, Annette Szumski, Boxiong Tang, Sameer Kotak, Andrew S. Koenig, Radu Vasilescu
Dátum:2013
ISSN:0770-3198
Megjegyzések:Biologics have mainly been assessed in patients with severe rheumatoid arthritis (RA) globally. Less attention has been paid to moderately active disease, especially in Central and Eastern Europe (CEE). Access to biologics and the disease features of RA patients may differ in CEE, relative to other regions. We assessed the clinical and patient-reported outcomes (PROs) of treatment from CEE patients in the multinational PRESERVE study ( NCT00565409 ). Patients with moderate RA 28-joint disease activity score ((DAS28) erythrocyte sedimentation rate (ESR) >3.2 and 5.1) despite methotrexate (MTX) treatment received open-label etanercept (ETN) 50 mg QW + MTX for 36 weeks. Low disease activity (DAS28 low disease activity (LDA) 3.2) and remission (DAS28 ESR <2.6) were assessed. PROs included Health Assessment Questionnaire Disability Index (HAQ-DI), patient global assessment (PGA), EuroQol-5 Dimension (EQ-5D), pain visual analogue scale (VAS), Medical Outcomes Study sleep questionnaire (MOS Sleep), Functional Assessment of Chronic Illness Therapy (FACIT), and Work Productivity and Activity Impairment for RA (WPAI-RA). Descriptive summary statistics were employed. Of the 834 enrolled patients, 302 were from CEE. At baseline, CEE patients had similar disease states versus the overall population. By week 36, LDA was achieved by 87 %, remission by 67 %, and normal HAQ-DI (0.5) by 53 % of patients. Mean scores (SDs) for PROs significantly improved by week 36 as follows: HAQ-DI total by -0.6 (0.5); PGA by -2.4 (2.1); EQ-5D total index by 0.2 (0.2). Pain VAS, MOS Sleep, FACIT, and WPAI-RA also showed significant improvements. In conclusion, induction therapy with ETN + MTX led to DAS28 LDA, remission, and improvements in PROs in most CEE patients with moderately active RA despite treatment with MTX. These results are similar to the overall study population in the PRESERVE trial.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
köszvény
Megjelenés:Clinical Rheumatology. - 32 : 9 (2013), p. 1275-1281. -
További szerzők:Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Damjanov, Nemanja Majdan, Maria Nasonov, Evgeny Mazurov, Vadim Fabó Tibor Bananis, Eustratios Jones, Heather Szumski, Annette Tang, Boxiong Kotak, Sameer Koenig, Andrew S. Vasilescu, Radu
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1